Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer

scientific article published on 16 June 2009

Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1050293306
P356DOI10.1038/SJ.BJC.6605141
P932PMC publication ID2720214
P698PubMed publication ID19536088
P5875ResearchGate publication ID26301044

P2093author name stringS Napoletano
A J Ryan
J H Harmey
P A Fitzpatrick
C A Currid
N C O'Sullivan
P2860cites workThe insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-AQ22009032
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Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-AQ28616725
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisitedQ29547915
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Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3.Q33947270
Cleavage analysis of insulin-like growth factor (IGF)-dependent IGF-binding protein-4 proteolysis and expression of protease-resistant IGF-binding protein-4 mutantsQ38297936
IGFBP-4 degradation by pregnancy-associated plasma protein-A in MC3T3 osteoblastsQ40492882
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Overexpression of an inhibitory insulin-like growth factor binding protein (IGFBP), IGFBP-4, delays onset of prostate tumor formationQ41021607
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Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanismQ43610678
Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophyQ43940100
Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasionQ44128389
Expression of insulin-like growth factor I (IGF-I) gene and of genes for IGF-binding proteins 1, 2, 3, 4 (IGFBP-1-IGFBP-4) in non-neoplastic human thyroid cells and in certain human thyroid cancers. Effect of exogenous IGF-I on this expression.Q44852228
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Protease-resistant insulin-like growth factor (IGF)-binding protein-4 inhibits IGF-I actions and neointimal expansion in a porcine model of neointimal hyperplasia.Q53539688
Circulating concentrations of insulin-like growth factor I and risk of breast cancerQ57751183
Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblastsQ70062702
Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancerQ70565385
In vivo inhibition of insulin-like growth factor I gene expression by tamoxifenQ70646161
Insulin-like growth factor-binding proteins in R3230AC mammary tumors of intact and diabetic ratsQ72097443
Insulin-like growth factor binding protein (IGFBP) substrate zymography. A new tool to identify and characterize IGFBP-degrading proteinasesQ74114890
United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)Q74155605
Modifications of insulin-like growth factor binding proteins and their role in controlling IGF actionsQ77469837
Models for spontaneous metastasisQ79182088
Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivoQ79929885
Effects of growth-factor combinations on vascular endothelial cell growth in vitroQ81347761
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
preproinsulinQ7240673
murine modelQ122890741
P304page(s)278-286
P577publication date2009-06-16
P1433published inBritish Journal of CancerQ326309
P1476titleExpression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer
P478volume101

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cites work (P2860)
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