Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons

scientific journal article

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NI.2429
P698PubMed publication ID23042151
P5875ResearchGate publication ID232220667

P50authorPaul N MoynaghQ37379627
John J CallananQ45423950
Bernard P. MahonQ45449019
Bingwei WangQ63562507
Mark MellettQ81251511
Jakub SiednienkoQ103780386
P2093author name stringShuo Yang
Nezira Delagic
Ruaidhri Jackson
Lisa S Tang
P2860cites workTRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKLQ21092160
TAK1 is a ubiquitin-dependent kinase of MKK and IKKQ24291454
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...Q24297037
Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligasesQ24298607
Pellino2 activates the mitogen activated protein kinase pathwayQ24305052
Characterization of Pellino2, a substrate of IRAK1 and IRAK4Q24308089
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-betaQ24311833
Direct activation of protein kinases by unanchored polyubiquitin chainsQ24324679
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complexQ24337456
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinaseQ24534145
Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1Q27653149
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6Q28115232
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4Q28211574
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signalingQ28278006
TRAF6 is a signal transducer for interleukin-1Q28291934
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunityQ28505401
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine productionQ28511245
Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signalingQ28511311
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6Q28584723
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signalingQ28646137
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirusQ29615029
Type I interferons in host defenseQ29615912
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathwaysQ29616209
Ubiquitin signalling in the NF-kappaB pathwayQ29616322
TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.Q33455769
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activationQ34311133
Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent mannerQ34421538
Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligasesQ34659316
Interferons in autoimmune and inflammatory diseases: regulation and rolesQ35603598
Type I interferons (alpha/beta) in immunity and autoimmunityQ36072422
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.Q36157993
TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathwayQ36188288
The NF-kappaB pathwayQ36284035
Pellino proteins: novel players in TLR and IL-1R signallingQ36884257
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.Q37118880
The Pellino family: IRAK E3 ligases with emerging roles in innate immune signallingQ37330930
Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9.Q37532221
Mal mediates TLR-induced activation of CREB and expression of IL-10.Q39577038
Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathwayQ39756241
TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1Q39949585
The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.Q40053108
The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent mannerQ40384271
Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding proteinQ42152339
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activationQ45345604
Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injuryQ45412912
The role of TBK1 and IKKε in the expression and activation of Pellino 1.Q49957175
Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factorQ57017358
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune systemQ62001017
Peli1 (rel)ieves autoimmunityQ84968422
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
Interferon regulatory factor 7Q21496522
TNF receptor-associated factor 6Q21497539
Pellino 3Q21980069
P304page(s)1055-1062
P577publication date2012-10-07
P1433published inNature ImmunologyQ1071725
P1476titlePellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons
P478volume13

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