Toward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platform

scientific article (publication date: 2014)

Toward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platform is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...997008L
P356DOI10.1371/JOURNAL.PONE.0097008
P932PMC publication ID4014593
P698PubMed publication ID24809695
P5875ResearchGate publication ID262189883

P2093author name stringWan-Chen Huang
Tao-Shih Hsieh
Yu-Shih Lin
Mei-Shya Chen
P2860cites workNuclease protection by Drosophila DNA topoisomerase II. Enzyme/DNA contacts at the strong topoisomerase II cleavage sites.Q38342686
A two-drug model for etoposide action against human topoisomerase IIalphaQ38359958
High-throughput assays for DNA gyrase and other topoisomerasesQ38756222
Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.Q40314755
Incomplete reversion of double stranded DNA cleavage mediated by Drosophila topoisomerase II: formation of single stranded DNA cleavage complex in the presence of an anti-tumor drug VM26Q40534513
Development and use of a high-throughput bacterial DNA gyrase assay to identify mammalian topoisomerase II inhibitors with whole-cell anticancer activityQ44502489
Minimal DNA requirement for topoisomerase II-mediated cleavage in vitroQ45169409
Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediateQ45387279
Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II.Q47070885
Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.Q51109804
Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogasterQ52518950
A homogeneous, high-throughput fluorescence anisotropy-based DNA supercoiling assay.Q54377994
Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeastQ70467353
Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanicaQ79455298
DNA topoisomerases: structure, function, and mechanismQ22065417
Cellular roles of dna topoisomerases: a molecular perspectiveQ22121990
Targeting DNA topoisomerase II in cancer chemotherapyQ24649711
Structural basis of type II topoisomerase inhibition by the anticancer drug etoposideQ27670929
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysQ28145712
DNA topoisomerases and their poisoning by anticancer and antibacterial drugsQ28284744
Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VIQ28486816
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionQ29400901
High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylaseQ33746199
Topoisomerase II as a target for anticancer drugs: when enzymes stop being niceQ33851826
Tumor cell death induced by topoisomerase-targeting drugs.Q34192665
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
All tangled up: how cells direct, manage and exploit topoisomerase functionQ35154537
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discoveryQ36062585
Drosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage siteQ36135719
Origin and evolution of DNA topoisomerasesQ36733344
Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseasesQ36754740
Real-time detection of DNA topological changes with a fluorescently labeled cruciform.Q37012979
Bacterial topoisomerase I as a target for discovery of antibacterial compoundsQ37108422
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingQ37108461
DNA topoisomerases: harnessing and constraining energy to govern chromosome topologyQ37255381
New mechanistic and functional insights into DNA topoisomerases.Q38089800
DNA topoisomerase poisons as antitumor drugsQ38286727
A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by human topoisomerase IIα.Q38317625
A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. A two-site model for enzyme-mediated DNA cleavageQ38331051
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e97008
P577publication date2014-01-01
P1433published inPLOS OneQ564954
P1476titleToward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platform
P478volume9

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cites work (P2860)
Q33725749Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans.
Q38611497Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy

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