review article | Q7318358 |
scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1012784409 |
P356 | DOI | 10.1007/S00253-011-3557-Z |
P932 | PMC publication ID | 3189412 |
P698 | PubMed publication ID | 21904817 |
P5875 | ResearchGate publication ID | 51636412 |
P50 | author | Anthony Maxwell | Q37380949 |
Frédéric Collin | Q59680862 | ||
P2093 | author name string | Shantanu Karkare | |
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ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase | Q43993322 | ||
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The action of the bacterial toxin microcin B17. Insight into the cleavage-religation reaction of DNA gyrase | Q44493496 | ||
Chromosomally encoded gyrase inhibitor GyrI protects Escherichia coli against DNA-damaging agents | Q44589034 | ||
Nucleotide binding to DNA gyrase causes loss of DNA wrap | Q44799104 | ||
Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase | Q46377091 | ||
An open conformation of the Thermus thermophilus gyrase B ATP-binding domain | Q27637851 | ||
Crystal structure of the Escherichia coli SbmC protein that protects cells from the DNA replication inhibitor microcin B17 | Q27638843 | ||
DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose | Q27639067 | ||
NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins | Q27639582 | ||
The solution structure of ParD, the antidote of the ParDE toxin-antitoxin module, provides the structural basis for DNA and toxin binding | Q27646891 | ||
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases | Q27655501 | ||
Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigation | Q27656386 | ||
Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain | Q27656829 | ||
Crystal structure of the DNA gyrase GyrA N-terminal domain fromMycobacterium tuberculosis | Q27657595 | ||
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase | Q27658456 | ||
A Conserved Mode of Protein Recognition and Binding in a ParD−ParE Toxin−Antitoxin Complex | Q27659672 | ||
A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function | Q27663749 | ||
Type IIA topoisomerase inhibition by a new class of antibacterial agents | Q27663884 | ||
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance | Q27664216 | ||
Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase | Q27664232 | ||
Structure and mechanism of DNA topoisomerase II | Q27732221 | ||
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study | Q27741104 | ||
Crystal structure of the breakage-reunion domain of DNA gyrase | Q27742546 | ||
Crystal structure of CcdB, a topoisomerase poison from E. coli | Q27766729 | ||
The quinolones: decades of development and use | Q28191758 | ||
The ATP-binding site of type II topoisomerases as a target for antibacterial drugs | Q28207771 | ||
A common mechanism of cellular death induced by bactericidal antibiotics | Q28246128 | ||
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs | Q28284744 | ||
Molecular mechanisms of drug inhibition of DNA gyrase | Q28287181 | ||
Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme | Q28486911 | ||
New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine | Q30909775 | ||
Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. | Q31063061 | ||
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. | Q31096529 | ||
The action of the bacterial toxin, microcin B17, on DNA gyrase | Q33271871 | ||
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors | Q33339829 | ||
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase | Q33556397 | ||
Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV | Q33883611 | ||
New classification and update on the quinolone antibiotics | Q33902621 | ||
At least two separate gene clusters are involved in albicidin production by Xanthomonas albilineans | Q36813442 | ||
Energy coupling in type II topoisomerases: why do they hydrolyze ATP? | Q36854054 | ||
Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents | Q36907300 | ||
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus | Q37190713 | ||
Recent advances in bacterial topoisomerase inhibitors | Q37191811 | ||
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology | Q37255381 | ||
Effects of magnesium and related divalent metal ions in topoisomerase structure and function. | Q37383911 | ||
Quinolones: action and resistance updated | Q37595559 | ||
DNA gyrase: subunit structure and ATPase activity of the purified enzyme | Q37596172 | ||
The aminocoumarins: biosynthesis and biology. | Q37603068 | ||
An unusual mechanism for resistance to the antibiotic coumermycin A1 | Q37603477 | ||
DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs | Q38344294 | ||
A journey in the world of DNA rings and beyond | Q38571383 | ||
A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site | Q39079987 | ||
The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage | Q39229147 | ||
Quinolone-binding pocket of DNA gyrase: role of GyrB. | Q39652111 | ||
In the presence of subunit A inhibitors DNA gyrase cleaves DNA fragments as short as 20 bp at specific sites | Q39718939 | ||
Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance | Q39731838 | ||
Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase. | Q39781473 | ||
GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin. | Q39781947 | ||
Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. | Q39783715 | ||
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli | Q39816339 | ||
Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones | Q48080383 | ||
Control of segregation of chromosomal DNA by sex factor F in Escherichia coli. Mutants of DNA gyrase subunit A suppress letD (ccdB) product growth inhibition | Q48174226 | ||
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities | Q48744539 | ||
Advances in structure-based drug design of novel bacterial topoisomerase inhibitors. | Q51720712 | ||
Molecular basis of gyrase poisoning by the addiction toxin CcdB. | Q52287398 | ||
Locking the DNA gate of DNA gyrase: investigating the effects on DNA cleavage and ATP hydrolysis. | Q53921739 | ||
Probing the two-gate mechanism of DNA gyrase using cysteine cross-linking. | Q53923658 | ||
Quinolone resistance from a transferable plasmid. | Q54143628 | ||
Characterization of a cinodine-resistant mutant of Escherichia coli. | Q54158936 | ||
The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase. | Q54223810 | ||
gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase. | Q54269895 | ||
Total synthesis of microcin B17 via a fragment condensation approach. | Q54372116 | ||
Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting. | Q54393558 | ||
Preliminary characterization of an antibiotic produced by Xanthomonas albilineans which inhibits DNA synthesis in Escherichia coli. | Q54451458 | ||
Small-angle X-ray scattering reveals the solution structure of the full-length DNA gyrase a subunit. | Q54491751 | ||
Microcin B17 blocks DNA replication and induces the SOS system in Escherichia coli. | Q54784670 | ||
The intrinsic ATPase of DNA gyrase | Q55062440 | ||
Probing the Binding of Coumarins and Cyclothialidines to DNA Gyrase† | Q57980003 | ||
The interaction of DNA gyrase with the bacterial toxin CcdB: evidence for the existence of two gyrase-CcdB complexes 1 1Edited by I. B. Holland | Q57980004 | ||
Mass Spectrometry Reveals That the Antibiotic Simocyclinone D8 Binds to DNA Gyrase in a “Bent-Over” Conformation: Evidence of Positive Cooperativity in Binding | Q58299773 | ||
Modular Structure of the Full-Length DNA Gyrase B Subunit Revealed by Small-Angle X-Ray Scattering | Q59694944 | ||
The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription 1 1J. Karn | Q59695031 | ||
The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs | Q59695062 | ||
Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase | Q59695072 | ||
sbmC, a stationary-phase induced SOS Escherichia coli gene, whose product protects cells from the DNA replication inhibitor microcin B17 | Q64389506 | ||
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break | Q64390754 | ||
Glycocinnamoylspermidines, a new class of antibiotics. I. Description and fermentation of the organism producing the LL-BM123 antibiotics | Q67355570 | ||
The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases | Q67505712 | ||
Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin | Q67916303 | ||
The DNA replication inhibitor microcin B17 is a forty-three-amino-acid protein containing sixty percent glycine | Q68236075 | ||
Characterization of the binding site for cyclothialidine on the B subunit of DNA gyrase | Q72315721 | ||
DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism | Q72428717 | ||
Microbial growth and production kinetics of Streptomyces antibioticus Tü 6040 | Q73956986 | ||
Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli | Q74088698 | ||
Glycocinnamoylspermidines, a new class of antibiotics. II. Isolation, physicochemical and biological properties of LL-BM123.BETA.,.GAMMA.1 and .GAMMA.2. | Q78418871 | ||
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases | Q79665036 | ||
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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains | Q80028550 | ||
The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold | Q33904609 | ||
How antibiotics kill bacteria: from targets to networks | Q33958766 | ||
Twisting of the DNA-binding surface by a beta-strand-bearing proline modulates DNA gyrase activity. | Q33959458 | ||
Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes | Q33969008 | ||
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. | Q33987554 | ||
Mechanism of plasmid-mediated quinolone resistance | Q34025874 | ||
The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action | Q34092838 | ||
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic | Q34107244 | ||
Quinolones: a comprehensive review | Q34115365 | ||
Glutamate racemase is an endogenous DNA gyrase inhibitor | Q34147905 | ||
Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde | Q34187326 | ||
Differences in effects on DNA gyrase activity between two glutamate racemases of Bacillus subtilis, the poly-gamma-glutamate synthesis-linking Glr enzyme and the YrpC (MurI) isozyme | Q34209278 | ||
Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors | Q34401201 | ||
Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor | Q34483705 | ||
Crystal structure of an N-terminal fragment of the DNA gyrase B protein. | Q34493198 | ||
DNA gyrase: structure and function. | Q34507230 | ||
Solution structures of DNA-bound gyrase | Q34513886 | ||
Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI. | Q34733375 | ||
Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins. | Q34982610 | ||
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase | Q35042255 | ||
Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme | Q35059616 | ||
Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity | Q35059655 | ||
Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance. | Q35124032 | ||
Catalytic topoisomerase II inhibitors in cancer therapy. | Q35187762 | ||
Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor | Q35238951 | ||
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli | Q35742369 | ||
In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groups | Q35758905 | ||
Energy coupling in DNA gyrase and the mechanism of action of novobiocin | Q35994466 | ||
The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cell | Q36064831 | ||
gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi | Q36107774 | ||
Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II. | Q36136076 | ||
A new family of low molecular weight antibiotics from enterobacteria | Q36500659 | ||
Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases | Q36754740 | ||
Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism. | Q36775907 | ||
P433 | issue | 3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | mechanism of action | Q3271540 |
DNA | Q7430 | ||
bacteria | Q10876 | ||
antibiotic | Q12187 | ||
P304 | page(s) | 479-497 | |
P577 | publication date | 2011-09-09 | |
2011-11-01 | |||
P1433 | published in | Applied Microbiology and Biotechnology | Q13553694 |
P1476 | title | Exploiting bacterial DNA gyrase as a drug target: current state and perspectives | |
P478 | volume | 92 |
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