Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.

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Exploiting bacterial DNA gyrase as a drug target: current state and perspectives. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1012784409
P356DOI10.1007/S00253-011-3557-Z
P932PMC publication ID3189412
P698PubMed publication ID21904817
P5875ResearchGate publication ID51636412

P50authorAnthony MaxwellQ37380949
Frédéric CollinQ59680862
P2093author name stringShantanu Karkare
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Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic centerQ27621859
In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibioticQ39832834
Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin proteinQ39840497
Mechanism of action of cinodine, a glycocinnamoylspermidine antibioticQ39855825
Biological characterization of cyclothialidine, a new DNA gyrase inhibitorQ39883723
Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteriaQ39938412
Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.Q39958978
Cloning and mapping of the genetic determinants for microcin B17 production and immunityQ39980792
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coliQ40087129
Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitorQ40286248
Evidence for a conformational change in the DNA gyrase-DNA complex from hydroxyl radical footprintingQ40399549
Cyclothialidine and its congeners: a new class of DNA gyrase inhibitorsQ40667220
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallographyQ41064279
The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyraseQ41079914
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of actionQ41093787
YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyraseQ41174909
Control of cell division by sex factor F in Escherichia coli. II. Identification of genes for inhibitor protein and trigger protein on the 42.84-43.6 F segmentQ41547303
Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerasesQ41925162
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damageQ42264322
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocinQ42549663
GyrI: a counter-defensive strategy against proteinaceous inhibitors of DNA gyraseQ42724331
Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damageQ42872445
Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.Q42947154
The phytotoxin albicidin is a novel inhibitor of DNA gyrase.Q42956928
DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic propertiesQ43111811
1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS.Q43498212
The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibitionQ43567998
ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyraseQ43993322
Glycocinnamoylspermidines, a new class of antibiotics. II. Isolation, physiocochemical and biological properties of LL-BM123beta, gamma1 and gamma2.Q44365753
The action of the bacterial toxin microcin B17. Insight into the cleavage-religation reaction of DNA gyraseQ44493496
Chromosomally encoded gyrase inhibitor GyrI protects Escherichia coli against DNA-damaging agentsQ44589034
Nucleotide binding to DNA gyrase causes loss of DNA wrapQ44799104
Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyraseQ46377091
An open conformation of the Thermus thermophilus gyrase B ATP-binding domainQ27637851
Crystal structure of the Escherichia coli SbmC protein that protects cells from the DNA replication inhibitor microcin B17Q27638843
DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the novioseQ27639067
NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteinsQ27639582
The solution structure of ParD, the antidote of the ParDE toxin-antitoxin module, provides the structural basis for DNA and toxin bindingQ27646891
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerasesQ27655501
Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigationQ27656386
Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domainQ27656829
Crystal structure of the DNA gyrase GyrA N-terminal domain fromMycobacterium tuberculosisQ27657595
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyraseQ27658456
A Conserved Mode of Protein Recognition and Binding in a ParD−ParE Toxin−Antitoxin ComplexQ27659672
A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase functionQ27663749
Type IIA topoisomerase inhibition by a new class of antibacterial agentsQ27663884
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistanceQ27664216
Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA GyraseQ27664232
Structure and mechanism of DNA topoisomerase IIQ27732221
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic studyQ27741104
Crystal structure of the breakage-reunion domain of DNA gyraseQ27742546
Crystal structure of CcdB, a topoisomerase poison from E. coliQ27766729
The quinolones: decades of development and useQ28191758
The ATP-binding site of type II topoisomerases as a target for antibacterial drugsQ28207771
A common mechanism of cellular death induced by bactericidal antibioticsQ28246128
DNA topoisomerases and their poisoning by anticancer and antibacterial drugsQ28284744
Molecular mechanisms of drug inhibition of DNA gyraseQ28287181
Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzymeQ28486911
New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidineQ30909775
Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA.Q31063061
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040.Q31096529
The action of the bacterial toxin, microcin B17, on DNA gyraseQ33271871
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitorsQ33339829
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyraseQ33556397
Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IVQ33883611
New classification and update on the quinolone antibioticsQ33902621
At least two separate gene clusters are involved in albicidin production by Xanthomonas albilineansQ36813442
Energy coupling in type II topoisomerases: why do they hydrolyze ATP?Q36854054
Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agentsQ36907300
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticusQ37190713
Recent advances in bacterial topoisomerase inhibitorsQ37191811
DNA topoisomerases: harnessing and constraining energy to govern chromosome topologyQ37255381
Effects of magnesium and related divalent metal ions in topoisomerase structure and function.Q37383911
Quinolones: action and resistance updatedQ37595559
DNA gyrase: subunit structure and ATPase activity of the purified enzymeQ37596172
The aminocoumarins: biosynthesis and biology.Q37603068
An unusual mechanism for resistance to the antibiotic coumermycin A1Q37603477
DNA gyrase can cleave short DNA fragments in the presence of quinolone drugsQ38344294
A journey in the world of DNA rings and beyondQ38571383
A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding siteQ39079987
The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavageQ39229147
Quinolone-binding pocket of DNA gyrase: role of GyrB.Q39652111
In the presence of subunit A inhibitors DNA gyrase cleaves DNA fragments as short as 20 bp at specific sitesQ39718939
Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistanceQ39731838
Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.Q39781473
GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.Q39781947
Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.Q39783715
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coliQ39816339
Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolonesQ48080383
Control of segregation of chromosomal DNA by sex factor F in Escherichia coli. Mutants of DNA gyrase subunit A suppress letD (ccdB) product growth inhibitionQ48174226
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activitiesQ48744539
Advances in structure-based drug design of novel bacterial topoisomerase inhibitors.Q51720712
Molecular basis of gyrase poisoning by the addiction toxin CcdB.Q52287398
Locking the DNA gate of DNA gyrase: investigating the effects on DNA cleavage and ATP hydrolysis.Q53921739
Probing the two-gate mechanism of DNA gyrase using cysteine cross-linking.Q53923658
Quinolone resistance from a transferable plasmid.Q54143628
Characterization of a cinodine-resistant mutant of Escherichia coli.Q54158936
The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase.Q54223810
gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.Q54269895
Total synthesis of microcin B17 via a fragment condensation approach.Q54372116
Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting.Q54393558
Preliminary characterization of an antibiotic produced by Xanthomonas albilineans which inhibits DNA synthesis in Escherichia coli.Q54451458
Small-angle X-ray scattering reveals the solution structure of the full-length DNA gyrase a subunit.Q54491751
Microcin B17 blocks DNA replication and induces the SOS system in Escherichia coli.Q54784670
The intrinsic ATPase of DNA gyraseQ55062440
Probing the Binding of Coumarins and Cyclothialidines to DNA Gyrase†Q57980003
The interaction of DNA gyrase with the bacterial toxin CcdB: evidence for the existence of two gyrase-CcdB complexes 1 1Edited by I. B. HollandQ57980004
Mass Spectrometry Reveals That the Antibiotic Simocyclinone D8 Binds to DNA Gyrase in a “Bent-Over” Conformation: Evidence of Positive Cooperativity in BindingQ58299773
Modular Structure of the Full-Length DNA Gyrase B Subunit Revealed by Small-Angle X-Ray ScatteringQ59694944
The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription 1 1J. KarnQ59695031
The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugsQ59695062
Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyraseQ59695072
sbmC, a stationary-phase induced SOS Escherichia coli gene, whose product protects cells from the DNA replication inhibitor microcin B17Q64389506
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand breakQ64390754
Glycocinnamoylspermidines, a new class of antibiotics. I. Description and fermentation of the organism producing the LL-BM123 antibioticsQ67355570
The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerasesQ67505712
Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidinQ67916303
The DNA replication inhibitor microcin B17 is a forty-three-amino-acid protein containing sixty percent glycineQ68236075
Characterization of the binding site for cyclothialidine on the B subunit of DNA gyraseQ72315721
DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanismQ72428717
Microbial growth and production kinetics of Streptomyces antibioticus Tü 6040Q73956986
Identification of DNA gyrase inhibitor (GyrI) in Escherichia coliQ74088698
Glycocinnamoylspermidines, a new class of antibiotics. II. Isolation, physicochemical and biological properties of LL-BM123.BETA.,.GAMMA.1 and .GAMMA.2.Q78418871
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerasesQ79665036
Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysisQ79973060
Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strainsQ80028550
The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel foldQ33904609
How antibiotics kill bacteria: from targets to networksQ33958766
Twisting of the DNA-binding surface by a beta-strand-bearing proline modulates DNA gyrase activity.Q33959458
Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexesQ33969008
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.Q33987554
Mechanism of plasmid-mediated quinolone resistanceQ34025874
The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone actionQ34092838
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibioticQ34107244
Quinolones: a comprehensive reviewQ34115365
Glutamate racemase is an endogenous DNA gyrase inhibitorQ34147905
Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. HydeQ34187326
Differences in effects on DNA gyrase activity between two glutamate racemases of Bacillus subtilis, the poly-gamma-glutamate synthesis-linking Glr enzyme and the YrpC (MurI) isozymeQ34209278
Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitorsQ34401201
Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitorQ34483705
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.Q34493198
DNA gyrase: structure and function.Q34507230
Solution structures of DNA-bound gyraseQ34513886
Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI.Q34733375
Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.Q34982610
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyraseQ35042255
Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzymeQ35059616
Nalidixic acid resistance: A second genetic character involved in DNA gyrase activityQ35059655
Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance.Q35124032
Catalytic topoisomerase II inhibitors in cancer therapy.Q35187762
Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitorQ35238951
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coliQ35742369
In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groupsQ35758905
Energy coupling in DNA gyrase and the mechanism of action of novobiocinQ35994466
The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cellQ36064831
gyrB mutations in coumermycin A1-resistant Borrelia burgdorferiQ36107774
Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II.Q36136076
A new family of low molecular weight antibiotics from enterobacteriaQ36500659
Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseasesQ36754740
Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism.Q36775907
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmechanism of actionQ3271540
DNAQ7430
bacteriaQ10876
antibioticQ12187
P304page(s)479-497
P577publication date2011-09-09
2011-11-01
P1433published inApplied Microbiology and BiotechnologyQ13553694
P1476titleExploiting bacterial DNA gyrase as a drug target: current state and perspectives
P478volume92

Reverse relations

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