The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage

scientific article published on October 2001

The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/29.20.4224
P932PMC publication ID60217
P698PubMed publication ID11600711
P5875ResearchGate publication ID277493168

P2093author name stringRichter S
Moro S
Capranico G
Palumbo M
Gatto B
P2860cites work57 Sequencing end-labeled DNA with base-specific chemical cleavagesQ27860479
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesionsQ33631024
Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2.Q33799704
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustardsQ34196908
Local supercoil-stabilized DNA structuresQ34922005
Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerasesQ34930322
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complexQ35890421
Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustardsQ36102691
Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purificationQ36701793
Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sitesQ36792820
Diepoxybutane cross-links DNA at 5'-GNC sequencesQ38321063
Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisonsQ40983344
Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycleQ41930981
DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agentsQ42205544
Interactions between twisted DNAs and enzymes: the effects of superhelical turnsQ45210876
An all atom force field for simulations of proteins and nucleic acidsQ46625508
A contribution to the study of the structure-mutagenicity relationship for alpha-dicarbonyl compounds using the Ames test.Q50172509
Apurinic sites are position-specific topoisomerase II poisons.Q52552043
DNA modifications by the mutagen glyoxal: adduction to G and C, deamination of C and GC and GA cross-linking.Q53430910
UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from Streptomyces sp.Q54349517
Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne.Q54586920
Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyraseQ59695072
Topoisomerase II-mediated DNA cleavage activity and irreversibility of cleavable complex formation induced by DNA intercalator with alkylating capabilityQ67841901
Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidinQ67916303
Covalent modification and single-strand scission of DNA by a new antitumor antibiotic kapurimycin A3Q68649230
Fermentation, isolation and characterization of antibiotic PR-1350Q71234600
Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibioticsQ72871493
Irreversible and reversible topoisomerase II DNA cleavage stimulated by clerocidin: sequence specificity and structural drug determinantsQ73306198
UCT-4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from streptomyces sp.Q78421049
Terpentecin and UCT4B, New Family of Topoisomerase II Targeting Antitumor Antibiotics Produced by Streptomyces: Producing Organism, Frementation and Large Scale Purification.Q104403392
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)4224-4230
P577publication date2001-10-01
P1433published inNucleic Acids ResearchQ135122
P1476titleThe topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage
P478volume29

Reverse relations

cites work (P2860)
Q92882958Albicidin, a potent DNA gyrase inhibitor with clinical potential
Q39958978Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.
Q42872445Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage
Q42264322Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage
Q40250218Concerted bis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA.
Q40540102Cytotoxic and DNA-damaging effects of diterpenoid quinones from the roots of Salvia officinalis L. on colonic and hepatic human cells cultured in vitro
Q28484656Differential targeting of unpaired bases within duplex DNA by the natural compound clerocidin: a valuable tool to dissect DNA secondary structure
Q48100249Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G.
Q34214929Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
Q51754682Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death.
Q38495295Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest
Q34707948Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex
Q60049780Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining

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