SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.

scientific article published on 8 April 2015

SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2015.03.019
P932PMC publication ID4451461
P698PubMed publication ID25861759
P5875ResearchGate publication ID274736778

P7228access restriction statusopen accessQ232932
P50authorAnthony MaxwellQ37380949
Gregory L. ChallisQ38545126
Martin SchäferQ39401461
Mark J ButtnerQ55764039
Tung Bk LeQ57025563
P2093author name stringBarrie Wilkinson
Stephen J Hearnshaw
P2860cites workInhibition Kinetics and Emodin Cocrystal Structure of a Type II Polyketide Ketoreductase † , ‡Q27649562
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyraseQ27658456
Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepressionQ27666812
Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and RegiospecificitiesQ27670915
The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove bindingQ27671684
A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of InhibitionQ27681978
Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesisQ27685213
Protein structure prediction on the Web: a case study using the Phyre serverQ27860664
Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene clusterQ28534635
Chemical conditionality: a genetic strategy to probe organelle assemblyQ30160257
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosminQ30764407
Artificial chromosomes for antibiotic-producing actinomycetesQ30843383
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040.Q31096529
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolismQ33664511
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clustersQ34010109
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibioticQ34107244
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substancesQ34750112
Development of the quinolonesQ35110229
A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesisQ35488903
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursorsQ35680284
Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces.Q35835052
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticusQ37190713
Quinolones: action and resistance updatedQ37595559
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolitesQ37599348
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of actionQ41093787
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.Q41761257
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040 II. Structure elucidation and biosynthesisQ43996029
Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathwayQ46393035
Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesisQ46424044
Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus.Q47750952
Classification and nomenclature of the superfamily of short-chain dehydrogenases/reductases (SDRs).Q48629459
Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov modelsQ48662216
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activitiesQ48744539
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.Q54358881
Mass Spectrometry Reveals That the Antibiotic Simocyclinone D8 Binds to DNA Gyrase in a “Bent-Over” Conformation: Evidence of Positive Cooperativity in BindingQ58299773
The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†Q59695045
Simocyclinones: diversity of metabolites is dependent on fermentation conditionsQ77460135
Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tue 6040. II. Structure Elucidation and Biosynthesis.Q78429069
Improved mutasynthetic approaches for the production of modified aminocoumarin antibioticsQ80843949
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectantibioticQ12187
Streptomyces coelicolorQ2355919
Streptomyces albidoflavusQ22286833
7-oxo-SD8Q104667195
P6954online access statusopen accessQ232932
P304page(s)2192-2204
P577publication date2015-04-08
P1433published inJournal of Molecular BiologyQ925779
P1476titleSimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone
P478volume427

Reverse relations

cites work (P2860)
Q46263843Structural insights into simocyclinone as an antibiotic, effector ligand, and substrate
Q39401404Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate

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