scholarly article | Q13442814 |
P7228 | access restriction status | open access | Q232932 |
P50 | author | Anthony Maxwell | Q37380949 |
Gregory L. Challis | Q38545126 | ||
Martin Schäfer | Q39401461 | ||
Mark J Buttner | Q55764039 | ||
Tung Bk Le | Q57025563 | ||
P2093 | author name string | Barrie Wilkinson | |
Stephen J Hearnshaw | |||
P2860 | cites work | Inhibition Kinetics and Emodin Cocrystal Structure of a Type II Polyketide Ketoreductase † , ‡ | Q27649562 |
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase | Q27658456 | ||
Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression | Q27666812 | ||
Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities | Q27670915 | ||
The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding | Q27671684 | ||
A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of Inhibition | Q27681978 | ||
Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis | Q27685213 | ||
Protein structure prediction on the Web: a case study using the Phyre server | Q27860664 | ||
Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster | Q28534635 | ||
Chemical conditionality: a genetic strategy to probe organelle assembly | Q30160257 | ||
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin | Q30764407 | ||
Artificial chromosomes for antibiotic-producing actinomycetes | Q30843383 | ||
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. | Q31096529 | ||
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism | Q33664511 | ||
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters | Q34010109 | ||
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic | Q34107244 | ||
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives. | Q34214929 | ||
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances | Q34750112 | ||
Development of the quinolones | Q35110229 | ||
A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis | Q35488903 | ||
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors | Q35680284 | ||
Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces. | Q35835052 | ||
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus | Q37190713 | ||
Quinolones: action and resistance updated | Q37595559 | ||
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites | Q37599348 | ||
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action | Q41093787 | ||
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. | Q41761257 | ||
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040 II. Structure elucidation and biosynthesis | Q43996029 | ||
Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway | Q46393035 | ||
Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesis | Q46424044 | ||
Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus. | Q47750952 | ||
Classification and nomenclature of the superfamily of short-chain dehydrogenases/reductases (SDRs). | Q48629459 | ||
Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models | Q48662216 | ||
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities | Q48744539 | ||
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. | Q54358881 | ||
Mass Spectrometry Reveals That the Antibiotic Simocyclinone D8 Binds to DNA Gyrase in a “Bent-Over” Conformation: Evidence of Positive Cooperativity in Binding | Q58299773 | ||
The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein† | Q59695045 | ||
Simocyclinones: diversity of metabolites is dependent on fermentation conditions | Q77460135 | ||
Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tue 6040. II. Structure Elucidation and Biosynthesis. | Q78429069 | ||
Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics | Q80843949 | ||
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | antibiotic | Q12187 |
Streptomyces coelicolor | Q2355919 | ||
Streptomyces albidoflavus | Q22286833 | ||
7-oxo-SD8 | Q104667195 | ||
P6954 | online access status | open access | Q232932 |
P304 | page(s) | 2192-2204 | |
P577 | publication date | 2015-04-08 | |
P1433 | published in | Journal of Molecular Biology | Q925779 |
P1476 | title | SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone | |
P478 | volume | 427 |
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