YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function

scientific article published on 3 March 2017

YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACS.CHEMREV.6B00623
P932PMC publication ID5406272
P698PubMed publication ID28256131

P50authorJames Henderson NaismithQ17507299
Douglas A MitchellQ52356861
P2093author name stringBrandon J Burkhart
Greg Mann
Christopher J Schwalen
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Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.Q41906988
Dissecting Bottromycin Biosynthesis Using Comparative Untargeted MetabolomicsQ41920228
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Thiostrepton, proteasome inhibitors and FOXM1.Q43070511
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Drug discovery: Chemical beauty contestQ43409217
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Biosynthesis of the thiazolylpeptide antibiotic GE2270.Q43891329
Characterization of the binding sites of protein L11 and the L10.(L12)4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coliQ43959097
Total synthesis and stereochemical assignment of baringolin.Q44006630
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Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus InfectionQ36053593
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Expression of tfx and sensitivity to the rhizobial peptide antibiotic trifolitoxin in a taxonomically distinct group of alpha-proteobacteria including the animal pathogen Brucella abortusQ36060975
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Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicinQ36069657
Micrococcin, an antibacterial substance formed by a strain of MicrococcusQ36131402
Thiostrepton inhibition of tRNA delivery to the ribosomeQ36148327
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Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571Q36171778
Physical and genetic map of the major nif gene cluster from Azotobacter vinelandii.Q36174427
DNA sequence, products, and transcriptional pattern of the genes involved in production of the DNA replication inhibitor microcin B17.Q36174546
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The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reactionQ36246164
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Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferaseQ36322516
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Multidimensional annotation of the Escherichia coli K-12 genomeQ36360689
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Biochemical characterization of resistance determinants cloned from antibiotic-producing streptomycetesQ36387556
A Novel Function of Molecular Chaperone HSP70: SUPPRESSION OF ONCOGENIC FOXM1 AFTER PROTEOTOXIC STRESSQ36419222
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Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.Q36691575
Cardiolipin and the osmotic stress responses of bacteriaQ36755195
In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide ThiomuracinQ36761831
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Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism.Q36775907
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Total synthesis and revision of stereochemistry of the marine metabolite trunkamide A.Q53911867
Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis.Q53991201
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Probing the reactivity of the GTP- and GDP-bound conformations of elongation factor Tu in complex with the antibiotic GE2270 A.Q54648036
The maturation pathway of microcin B17, a peptide inhibitor of DNA gyrase.Q54653870
Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton.Q54690264
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Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividansQ71127774
A new antibiotic, multhiomycinQ71444257
On the site of action of bottromycin A2Q71540069
Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moietyQ71592548
Studies on translocation. VI. Thiostrepton prevents the formation of a ribosome-G factor-guanine nucleotide complexQ71612759
Antibiotic GE37468 A: A New Inhibitor of Bacterial Protein Synthesis. I. Isolation and CharacterizationQ71822165
Bacteriocins of gram-positive bacteriaQ71852767
Bottromycin. Separation of biologically active compounds and preparation and testing of amide derivativesQ72091563
Activity of bottromycin against Mycoplasma gallisepticumQ72096071
Novel antibiotics, amythiamicins. IV. A mutation in the elongation factor Tu gene in a resistant mutant of B. subtilisQ72131877
Inhibition of rhizobia by a strain of Rhizobeium trifolii: some properties of the antibiotic and of the strainQ72187005
Promoinducin, a novel thiopeptide produced by Streptomyces sp. SF2741Q72328034
Derivatives of bottromycin A2 and their biological activityQ72348245
Promothiocins A and B novel thiopeptides with a tipA promoter inducing activity produced by Streptomyces sp. SF2741Q72465216
Concerning the mode of action of micrococcin upon bacterial protein synthesisQ72498090
Microbial metabolites with tipA promoter inducing activity. III. Thioxamycin and its novel derivative, thioactin, two thiopeptides produced by Streptomyces sp. DP94Q72513396
Revised structure of the antibiotic GE 2270AQ72513439
The Mode of Action of Berninamycin and the Mechanism of Resistance in the Producing Organism, Streptomyces bernensisQ72676564
Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibioticsQ72714851
Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. II. Isolation and physical-chemical characterizationQ72723137
Collismycins A and B, novel non-steroidal inhibitors of dexamethasone-glucocorticoid receptor bindingQ72723205
Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84Q72723211
Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin DQ72807142
Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and CQ72807146
Cross-hypersensitivity effects of mutations in 23 S rRNA yield insight into aminoacyl-tRNA bindingQ72819699
The structure of bottromycin A2, a new component of bottromycinsQ72935853
The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor microcin B17Q73000077
Targeted screening for elongation factor Tu binding antibioticsQ73147788
Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionalityQ73201411
Expressed protein ligation to probe regiospecificity of heterocyclization in the peptide antibiotic microcin B17Q73211803
Kawaguchipeptin B, an antibacterial cyclic undecapeptide from the cyanobacterium Microcystis aeruginosaQ73570137
Cloning of a chromosomal region responsible for streptolysin S production in Streptococcus pyogenesQ73791652
Identification of DNA gyrase inhibitor (GyrI) in Escherichia coliQ74088698
Using Genomics for Natural Product Structure ElucidationQ38604507
How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.Q38604743
Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.Q38625630
Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its DerivativesQ38826881
The C-terminal part of microcin B is crucial for DNA gyrase inhibition and antibiotic uptake by sensitive cellsQ38850414
Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and MicrobeQ38981170
Mechanistic Understanding of Lanthipeptide Biosynthetic EnzymesQ39109460
The transcription factor FOXM1 is a cellular target of the natural product thiostreptonQ39486053
Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyraseQ39503102
Linkage map of Escherichia coli K-12, edition 10: the physical map.Q39523429
Trifolitoxin Production Increases Nodulation Competitiveness of Rhizobium etli CE3 under Agricultural ConditionsQ39561782
Proteasome inhibitory activity of thiazole antibioticsQ39625565
Reconstitution and Minimization of a Micrococcin Biosynthetic Pathway in Bacillus subtilisQ39628822
Role of tfxE, but not tfxG, in trifolitoxin resistanceQ39640541
Binding of Thiostrepton to a Complex of 23-S rRNA with Ribosomal Protein L11Q39676706
JBIR-83 and JBIR-84, new promothiocin derivatives, isolated from Streptomyces sp. RI19.Q39692495
Ribosomes in thiostrepton-resistant mutants of Bacillus megaterium lacking a single 50 S subunit proteinQ39712460
Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action.Q39720138
The peptide antibiotic microcin 25 is imported through the TonB pathway and the SbmA proteinQ39837132
Functional analysis of promoters in the nisin gene cluster of Lactococcus lactis.Q39841738
A newly discovered gene, tfuA, involved in the production of the ribosomally synthesized peptide antibiotic trifolitoxinQ39841989
Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cellsQ39851883
DNA sequence and mutational analysis of genes involved in the production and resistance of the antibiotic peptide trifolitoxinQ39929075
Recent developments of antibiotic research and classification of antibiotics according to chemical structureQ39950748
Evidence that colicin X is microcin B17.Q39957180
Novel anticancer compounds induce apoptosis in melanoma cellsQ39967759
Growth phase and ompR regulation of transcription of microcin B17 genesQ39970317
Cloning and mapping of the genetic determinants for microcin B17 production and immunityQ39980792
Gene ompR and regulation of microcin 17 and colicin e2 synthesesQ39987924
Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4Q39990304
Microcin plasmids: a group of extrachromosomal elements coding for low-molecular-weight antibiotics in Escherichia coliQ39990753
Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.Q39994987
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism.Q40009277
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1.Q40223971
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A.Q40225357
Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris.Q40254970
Insights into heterocyclization from two highly similar enzymesQ40286000
Streptococcal toxins (streptolysin O, streptolysin S, erythrogenic toxin).Q40295576
Thioviridamide, a novel apoptosis inducer in transformed cells from Streptomyces olivoviridisQ40299085
YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. I. fermentation, isolation and biological activitiesQ40438316
Propionibacterium acnes inhibits FOXM1 and induces cell cycle alterations in human primary prostate cells.Q40480953
Chemical crosslinking of elongation factor G to the 23S RNA in 70S ribosomes fromEscherichia coliQ40492145
Thiopeptide non-producing Streptomyces species carry the tipA gene: a clue to its functionQ74099038
Thiostrepton, a new antibiotic. II. Isolation and chemical characterizationQ74204457
Thiostrepton, a new antibiotic. III. In vivo studiesQ74204462
Mutational analysis of posttranslational heterocycle biosynthesis in the gyrase inhibitor microcin B17: distance dependence from propeptide and tolerance for substitution in a GSCG cyclizable sequenceQ74378000
Sch 40832: a novel thiostrepton from Micromonospora carbonaceaQ74449975
Novel semi-synthetic nocathiacin antibiotics: synthesis and antibacterial activity of bis- and mono-O-alkylated derivativesQ75191046
Biochemical studies on streptolysin S' formed in the presence of yeast ribonucleic acid. I. The purification and some properties of the toxinQ76489249
BIOCHEMICAL STUDIES ON STREPTOLYSIN S'. II. PROPERTIES OF A POLYPEPTIDE COMPONENT AND ITS ROLE IN THE TOXIN ACTIVITYQ76552799
Metalloenzyme nitrile hydratase: structure, regulation, and application to biotechnologyQ77085022
ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17Q77333164
Tenuecyclamides A-D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenueQ77449948
Goadsporin, a chemical substance which promotes secondary metabolism and morphogenesis in streptomycetes. I. Purification and characterizationQ77670691
New cyclic peptides from the ascidian Lissoclinum patellaQ77733972
Inhibition by thiostrepton of the formation of a ribosome-bound guanine nucleotide complexQ77914935
Inhibition by thiostrepton of the IF-2-dependent ribosomal GTPaseQ77919738
EFFECT OF STAPHYLOCOCCAL AND OTHER BACTERIAL TOXINS ON PLATELETS IN VITROQ78245089
Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes. II. Structure Determination.Q78428681
Studies on Bottromycins. II. Structure Elucidation of Bottromycins B2 and C2.Q78429250
Caerulomycin, a new antibiotic from Streptomyces caeruleus Baldacci. II. StructureQ78434943
Synthesis and antibacterial activity of O-substituted nocathiacin I derivativesQ80213348
The novel alkali tolerance function of tfxG in Sinorhizobium melilotiQ80473132
Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibioticsQ80858960
Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adductsQ81610279
YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. II. Physico-chemical properties and structure elucidationQ81618370
Heterologous production of thiostrepton A and biosynthetic engineering of thiostrepton analogsQ82604551
Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridisQ82990536
Synthesis and antibacterial activity of nocathiacin I analoguesQ83169162
Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amidesQ83843528
Synthesis and antibacterial activity of novel water-soluble nocathiacin analogsQ85484539
The importance of start codon of nosM in nosiheptide productionQ86822999
Total synthesis of the azolemycinsQ86952626
Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividansQ87031027
In vivo production of thiopeptide variantsQ87407476
Drug discovery: tools and rules for macrocyclesQ87413192
Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazolesQ87757867
One-pot synthesis of azoline-containing peptides in a cell-free translation system integrated with a posttranslational cyclodehydrataseQ87939557
Bryamycin, a new antibioticQ95549074
In vitro observations on A-8506 (bryamycin)Q95551196
Thiazole/oxazole-modified microcins: complex natural products from ribosomal templatesQ34172748
Linking chemistry and genetics in the growing cyanobactin natural products familyQ34180017
A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.Q34181822
Plantazolicin A and B: structure elucidation of ribosomally synthesized thiazole/oxazole peptides from Bacillus amyloliquefaciens FZB42.Q34184757
Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydrataseQ34188549
Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesisQ34207315
Nucleophilic 1,4-additions for natural product discovery.Q34211690
Antifungal thiopeptide cyclothiazomycin B1 exhibits growth inhibition accompanying morphological changes via binding to fungal cell wall chitinQ34212732
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.Q34219646
Plasmodium falciparum apicoplast drugs: targets or off-targets?Q34227325
Studies on thiopeptin antibiotics. I. Characteristics of thiopeptin BQ34234031
Thiostrepton, a new antibiotic. I. In vitro studiesQ34239583
Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton resistance methyltransferase (Tsr).Q34249082
Discovery, biosynthesis, and engineering of lantipeptidesQ34260063
Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteriaQ34265301
YcaO domains use ATP to activate amide backbones during peptide cyclodehydrationsQ34269958
Site of action of a ribosomal RNA methylase conferring resistance to thiostreptonQ34270244
Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesisQ34302589
Mutations in the GTPase center of Escherichia coli 23S rRNA indicate release factor 2-interactive sitesQ34304466
Mode of action of bottromycin A2. Release of aminoacyl- or peptidyl-tRNA from ribosomesQ34307700
The highly conserved TldD and TldE proteins of Escherichia coli are involved in microcin B17 processing and in CcdA degradationQ34312507
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclatureQ34312732
Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA.Q34323280
Draft Genome Sequence of Streptomyces bottropensis ATCC 25435, a Bottromycin-Producing ActinomyceteQ34334350
Total synthesis of the ribosomally synthesized linear azole-containing peptide plantazolicin A from Bacillus amyloliquefaciensQ34350499
Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasiteQ34361178
A roadmap for natural product discovery based on large-scale genomics and metabolomicsQ34364094
Biosynthesis and mode of action of lantibiotics.Q34392391
Thiopeptide antibioticsQ34392398
Characteristics of streptolysin S hemolysisQ34399206
Effect of streptolysin S on human and mouse T and B lymphocytesQ34408473
Regulation of the biosynthesis of thiopeptide antibiotic cyclothiazomycin by the transcriptional regulator SHJG8833 in Streptomyces hygroscopicus 5008.Q34417322
Genome shuffling and ribosome engineering of Streptomyces actuosus for high-yield nosiheptide productionQ34420023
Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferaseQ28280875
Protein homology detection by HMM-HMM comparisonQ28292161
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterizationQ28333398
Analysis of an inactive cyanobactin biosynthetic gene cluster leads to discovery of new natural products from strains of the genus MicrocystisQ28482661
Fragments of the bacterial toxin microcin B17 as gyrase poisonsQ28486124
Substrate recognition and modification by the nosiheptide resistance methyltransferaseQ28546693
De-DUFing the DUFs: Deciphering distant evolutionary relationships of Domains of Unknown Function using sensitive homology detection methodsQ28546880
Identification and Functional Analysis of the Nocardithiocin Gene Cluster in Nocardia pseudobrasiliensisQ28551056
Mass spectrometric analysis of 40 S ribosomal proteins from Rat-1 fibroblastsQ28575240
Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted miningQ28820976
Enzymatic Macrocyclization of 1,2,3-Triazole Peptide MimeticsQ28828607
Aromaticity as a Cornerstone of Heterocyclic ChemistryQ29029831
Molecular basis of symbiosis between Rhizobium and legumesQ29393489
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)Q29547307
Pathogenesis of group A streptococcal infectionsQ29615547
Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplastQ30080014
Hydration changes implicated in the remarkable temperature-dependent membrane permeation of cyclosporin A.Q30597715
Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparumQ30658099
In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sitesQ30697757
Natural history of the E1-like superfamily: implication for adenylation, sulfur transfer, and ubiquitin conjugationQ30855071
Conformation of cyclosporin A in polar solventsQ30897374
YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological PropertiesQ30919831
YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge. II. Structure ElucidationQ30919846
Antitumor peptides from marine organismsQ31040702
Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae diseaseQ31109211
Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived Claisen rearrangementsQ31111161
Antimicrobial evaluation of nocathiacins, a thiazole peptide class of antibioticsQ31115498
Characterization of the haemolytic activity of Streptococcus equiQ32071923
Methylsulfomycin I, a new cyclic peptide antibiotic from a Streptomyces sp. HIL Y-9420704.Q33179228
Solid-phase synthesis and stereochemical assignments of tenuecyclamides A-D employing heterocyclic amino acids derived from commercially available Fmoc alpha-amino acidsQ33204777
Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometryQ33227165
Isolation of genes involved in nodulation competitiveness from Rhizobium leguminosarum bv. trifolii T24.Q33238829
The action of the bacterial toxin, microcin B17, on DNA gyraseQ33271871
Mapping the binding site of thiopeptide antibiotics by proximity-induced covalent captureQ33326451
Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenesQ33369065
Thiostrepton biosynthesis: prototype for a new family of bacteriocinsQ33415323
Partition of ribosomes in two-polymer aqueous phase systemsQ45227392
The C-terminal extended serine residue is absolutely required in nosiheptide maturationQ45341026
Discovery of a biologically active thiostrepton fragment.Q45964621
Thiostrepton maturation involving a deesterification-amidation way to process the C-terminally methylated peptide backbone.Q45995906
Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosaQ46067549
Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide.Q46117027
Trifolitoxin Production and Nodulation Are Necessary for the Expression of Superior Nodulation Competitiveness by Rhizobium leguminosarum bv. trifolii Strain T24 on CloverQ46160893
Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyraseQ46377091
The apicoplast of Plasmodium falciparum is translationally active.Q46386660
Streptolysin S and necrotising infections produced by group G streptococcusQ46426077
Novel polyoxazole-based cyclopeptides from Streptomyces sp. Total synthesis of the cyclopeptide YM-216391 and synthetic studies towards telomestatinQ46595204
Effect analysis of mineral salt concentrations on nosiheptide production by Streptomyces actuosus Z-10 using response surface methodology.Q46774201
Antibiotic susceptibility of mammalian mitochondrial translationQ46791953
Cloning and characterization of the goadsporin biosynthetic gene cluster from Streptomyces sp. TP-A0584.Q46844379
Determination of the amino acid residues required for the activity of the anti-rhizobial peptide antibiotic trifolitoxinQ46944661
EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition.Q46953308
Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270.Q46969030
Biosynthetic Timing and Substrate Specificity for the Thiopeptide ThiomuracinQ47094522
Mode of action of berninamycin. An inhibitor of protein biosynthesisQ47680901
Protection of ribosomes from thiostrepton inactivation by the binding of G factor and guanosine diphosphateQ47729257
Studies on the formation of transfer ribonucleic acid-ribosome complexes. IV. Effect of antibiotics on steps of bacterial protein synthesis: some new ribosomal inhibitors of translocation.Q47733178
Inhibition by thiopeptin of ribosomal functions associated with T and G factorsQ47737761
Effect of siomycin on protein synthesizing activity of Escherichia coli ribosomesQ47748469
Multiple oxidative routes towards the maturation of nosiheptide.Q47793359
The effects of anti-bacterials on the malaria parasite Plasmodium falciparum.Q47823743
Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetaseQ47851523
Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparumQ47854324
Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptidesQ47869745
The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasitesQ48012620
Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostreptonQ48035340
Thiostrepton binds to malarial plastid rRNA.Q48036549
Elongation factor Tu1 of the antibiotic GE2270A producer Planobispora rosea has an unexpected resistance profile against EF-Tu targeted antibioticsQ48055040
An elongation factor Tu (EF-Tu) resistant to the EF-Tu inhibitor GE2270 in the producing organism Planobispora roseaQ48059487
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidiansQ48083632
Insights into the Biosynthesis of Dehydroalanines in Goadsporin.Q48095228
Mechanistic Insights into the Radical S-adenosyl-l-methionine Enzyme NosL From a Substrate Analogue and the Shunt ProductsQ48248930
Molecular characterization of pmbA, an Escherichia coli chromosomal gene required for the production of the antibiotic peptide MccB17.Q48250073
Radamycin, a novel thiopeptide produced by streptomyces sp. RSP9. I. Taxonomy, fermentation, isolation and biological activities.Q48731902
Glycothiohexides, novel antibiotics produced by "Sebekia" sp. LL-14E605. I. Taxonomy, fermentation and biological evaluation.Q48795126
Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity.Q48795728
Thiostrepton resistance mutations in the gene for 23S ribosomal RNA of halobacteria.Q50708683
Structure-activity relationships of thiostrepton derivatives: implications for rational drug design.Q51029309
Enhancing nosiheptide production in Streptomyces actuosus by heterologous expression of haemoprotein from Sinorhizobium meliloti.Q51364182
A synthesis of all stereoisomers of tenuecyclamide A employing a fluorous-Fmoc strategy.Q51784027
Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression.Q52535716
Fine-tuning of a radical-based reaction by radical S-adenosyl-L-methionine tryptophan lyase.Q52669486
Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.Q36781888
Thiostrepton, an Inhibitor of 50 S Ribosome Subunit FunctionQ36824003
Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical developmentQ36832446
Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second ResidueQ36843584
Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane.Q36857331
RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coliQ36882918
The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffoldsQ36884001
Low-molecular-weight post-translationally modified microcins.Q36915481
Unusual cytochrome p450 enzymes and reactionsQ36928916
From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptidesQ36939955
Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivativesQ36973864
Predicting protein function from sequence and structureQ37014089
A structural understanding of the dynamic ribosome machineQ37091739
Genetic analyses of the role of RCE1 in RAS membrane association and transformation.Q37138752
Apicoplast translation, transcription and genome replication: targets for antimalarial antibioticsQ37152316
A strain-variable bacteriocin in Bacillus anthracis and Bacillus cereus with repeated Cys-Xaa-Xaa motifsQ37172458
Engineering unnatural variants of plantazolicin through codon reprogrammingQ37198599
Follow the leader: the use of leader peptides to guide natural product biosynthesis.Q37237843
Ixabepilone: a new chemotherapeutic option for refractory metastatic breast cancerQ37290709
Recent advances in the chemistry and biology of naturally occurring antibioticsQ37313939
Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferaseQ37332924
Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and functionQ37361900
Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide frameworkQ37389799
Physical behavior of streptolysin SQ37399354
Lysosomal disruption by bacterial toxinsQ37408015
A coordinated proteomic approach for identifying proteins that interact with the E. coli ribosomal protein S12.Q37412066
A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic PathwayQ37412719
Pore-forming bacterial protein hemolysins (cytolysins).Q37420799
The requirement for ribosomal proteins L7 and L12 in peptide-chain terminationQ37428296
Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.Q37455595
Inhibition by siomycin and thiostrepton of both aminoacyl-tRNA and factor G binding to ribosomesQ37483051
Molecular basis for the broad substrate selectivity of a peptide prenyltransferaseQ37493158
An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclizationQ37515168
The cryo-EM structure of a translation initiation complex from Escherichia coliQ34423776
Multicenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infectionsQ34455320
Bacteriocins: developing innate immunity for foodQ34456947
HIV protease inhibitors block streptolysin S productionQ34462102
Chemoenzymatic synthesis of thiazolyl peptide natural products featuring an enzyme-catalyzed formal [4 + 2] cycloadditionQ34465798
Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products.Q34478499
Structural analysis of leader peptide binding enables leader-free cyanobactin processingQ34481795
Real-time PCR assay to differentiate Listeriolysin S-positive and -negative strains of Listeria monocytogenes.Q34483760
Spontaneity in the patellamide biosynthetic pathway.Q34493085
Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variantsQ34520644
Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of actionQ34552393
An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomerQ34570103
High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis.Q34576266
Structure/function relationships in OmpR and other winged-helix transcription factorsQ34588835
The generation of new protein functions by the combination of domainsQ34601959
A proteomic and transcriptomic approach reveals new insight into beta-methylthiolation of Escherichia coli ribosomal protein S12.Q34616840
An enzymatic route to selenazolinesQ34618172
In vitro activity of the nisin dehydratase NisB.Q34670018
Functional conformations of the L11-ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulationsQ34702863
Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence.Q34720911
Discovery of a widely distributed toxin biosynthetic gene clusterQ34765733
Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance systemQ34793047
Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expressionQ34798813
Structure of microcin B-like compounds produced by Pseudomonas syringae and species specificity of their antibacterial action.Q34818794
Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluationQ34869234
Structure determination and total synthesis of bottromycin A2: a potent antibiotic against MRSA and VRE.Q34912312
Inhibition of ribosomal A site functions by sporangiomycin and micrococcinQ34933648
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.Q34938493
Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modificationsQ34952729
Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.Q34972804
Conformational changes of elongation factor G on the ribosome during tRNA translocationQ34978694
Functional characterization of SbmA, a bacterial inner membrane transporter required for importing the antimicrobial peptide Bac7(1-35).Q35002035
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPasesQ35007821
FoxM1 is a general target for proteasome inhibitorsQ33492774
Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor familyQ33586774
Genetic locus for streptolysin S production by group A streptococcusQ33598605
Sonorensin: an antimicrobial peptide, belonging to the heterocycloanthracin subfamily of bacteriocins, from a new marine isolate, Bacillus sonorensis MT93.Q33601961
The RNA-binding domain of ribosomal protein L11 recognizes an rRNA tertiary structure stabilized by both thiostrepton and magnesium ionQ33620601
The hidden diversity of ribosomal peptide natural productsQ33622826
Enzymatic formation of C-terminal amidesQ33636919
Thiazole and oxazole peptides: biosynthesis and molecular machineryQ33636923
From complete genome sequence to 'complete' understanding?Q33637109
Ribosomal mechanics, antibiotics, and GTP hydrolysisQ33641403
C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivityQ40534768
Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysisQ40559607
Crystallographic analysis of NosA, which catalyzes terminal amide formation in the biosynthesis of nosiheptideQ40651936
Modularity of RiPP Enzymes Enables Designed Synthesis of Decorated PeptidesQ40747661
Antibiotic interactions at the GTPase-associated centre within Escherichia coli 23S rRNA.Q40817267
Autogenous transcriptional activation of a thiostrepton-induced gene in Streptomyces lividans.Q40873644
Sonorensin: A new bacteriocin with potential of an anti-biofilm agent and a food biopreservativeQ41041363
STUDIES ON LYSOSOMES. IV. SOLUBILIZATION OF ENZYMES DURING MITOCHONDRIAL SWELLING AND DISRUPTION OF LYSOSOMES BY STREPTOLYSIN S AND OTHER HEMOLYTIC AGENTS.Q41060347
Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264Q41068761
The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyraseQ41079914
New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu.Q41080279
Throwing a spanner in the works: antibiotics and the translation apparatusQ41168564
Kinetically competent intermediates in the translocation step of protein synthesisQ41353918
Ribosomally synthesized antimicrobial peptides: their function, structure, biogenesis, and mechanism of actionQ41356005
In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products.Q41492401
A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell lineQ41540847
NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptideQ41581608
Ribose methylation and resistance to thiostreptonQ41582412
Subinhibitory concentrations of LFF571 reduce toxin production by Clostridium difficileQ41596897
Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocationQ41632068
The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene clusterQ41718525
Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalystQ41772183
Construction of a Symbiotically Effective Strain of Rhizobium leguminosarum bv. trifolii with Increased Nodulation Competitiveness.Q41862922
P433issue8
P304page(s)5389-5456
P577publication date2017-03-03
P1433published inChemical ReviewsQ900502
P1476titleYcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function
P478volume117

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