Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay.

scientific article published on 17 May 2013

Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/1087057113487208
P698PubMed publication ID23686103

P2093author name stringBryan P Kwan
Mark L Cunningham
Karen J Shaw
Daniel C Bensen
Kirk J Nelson
P2860cites workMechanistic studies and biological activity of bioxalomycin alpha 2, a novel antibiotic produced by Streptomyces viridodiastaticus subsp. "litoralis" LL-31F508.Q33756862
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Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examplesQ35816625
Antibiotics: where did we go wrong?Q36022317
DNA gyrase on the bacterial chromosome: possibility of two levels of actionQ36416888
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Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY146032)Q39816283
Mechanism of action and in vitro and in vivo activities of S-6123, a new oxazolidinone compoundQ39832267
Nalidixic Acid: an Antibacterial ParadoxQ40944835
Specific stimulation of ribosomal RNA synthesis in E. coli by a protein factorQ42466637
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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.Q45207323
Consequences of daptomycin-mediated membrane damage in Staphylococcus aureusQ46453501
The mechanism of inhibition of topoisomerase IV by quinolone antibacterialsQ46829877
P433issue9
P921main subjectdrug discoveryQ1418791
macromoleculeQ178593
P304page(s)1018-1026
P577publication date2013-05-17
P1433published inJournal of Biomolecular ScreeningQ6294856
P1476titleDistinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay.
P478volume18

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cites work (P2860)
Q36489323A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli
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Q38367630Mutant Alleles of lptD Increase the Permeability of Pseudomonas aeruginosa and Define Determinants of Intrinsic Resistance to Antibiotics
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