Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor

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Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.01158-10
P932PMC publication ID3019687
P698PubMed publication ID20937785

P50authorLesley A MitchenallQ84343281
Anthony MaxwellQ37380949
P2093author name stringJohn S Blanchard
Matthew W Vetting
Subray S Hegde
P2860cites workDNA gyrase, topoisomerase IV, and the 4-quinolonesQ24643546
Emerging mechanisms of fluoroquinolone resistanceQ24644842
Plasmid-mediated quinolone resistance: a multifaceted threatQ24645356
Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142Q24648111
Pentapeptide repeat proteinsQ24653739
Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehydeQ24655366
A model for the mechanism of strand passage by DNA gyraseQ24675025
Insights into the structural variation between pentapeptide repeat proteins--crystal structure of Rfr23 from Cyanothece 51142Q27649420
Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistanceQ27649912
Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡Q27651667
Crystal structure of the breakage-reunion domain of DNA gyraseQ27742546
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinantsQ33369591
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyraseQ33556397
Plasmid-mediated quinolone resistanceQ82262149
Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IVQ33883611
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.Q33987554
Efflux-mediated resistance to fluoroquinolones in gram-negative bacteriaQ34010692
Mechanism of plasmid-mediated quinolone resistanceQ34025874
Mechanisms of action and resistance of older and newer fluoroquinolonesQ34030757
Mechanisms of action of antimicrobials: focus on fluoroquinolonesQ34183520
qnrB, another plasmid-mediated gene for quinolone resistanceQ34510366
The worldwide emergence of plasmid-mediated quinolone resistanceQ34569740
Fluoroquinolone resistance among Gram-positive cocciQ34807455
Fluoroquinolones: action and resistanceQ35061150
Efflux-mediated drug resistance in bacteriaQ35626332
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerasesQ35771555
Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coliQ35879095
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolateQ36094929
Quinolone resistance in bacteria: emphasis on plasmid-mediated mechanismsQ36125234
Mechanisms of resistance to quinolonesQ36155441
qnr Gene nomenclatureQ36744808
Effects of quinolones on nucleoid segregation in Escherichia coliQ36757605
Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophiliaQ36932986
Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year periodQ37072043
The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complexQ37110496
Plasmid-mediated quinolone resistance in gram-negative bacterial species: an updateQ37411359
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase productionQ39671025
Topoisomerase Poisons: Harnessing the Dark Side of Enzyme MechanismQ40476934
Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolonesQ41825585
Origin of plasmid-mediated quinolone resistance determinant QnrA.Q42112652
Vibrionaceae as a possible source of Qnr-like quinolone resistance determinantsQ42670804
Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp.Q43230457
Smaqnr, a new chromosome-encoded quinolone resistance determinant in Serratia marcescensQ43234867
In vivo selection of a target/efflux double mutant of Pseudomonas aeruginosa by ciprofloxacin therapyQ43753592
Postantibiotic effect of CI-960, enoxacin and ciprofloxacin on Escherichia coli: effect on morphology and haemolysin activityQ44046430
Qnr-like pentapeptide repeat proteins in gram-positive bacteriaQ44351734
The killing effect of cryptolepine on Staphylococcus aureusQ45197137
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferaseQ46862305
Quinolone resistance from a transferable plasmid.Q54143628
DNA gyrase-mediated wrapping of the DNA strand is required for the replication fork arrest by the DNA gyrase-quinolone-DNA ternary complexQ73128318
Identification of DNA gyrase inhibitor (GyrI) in Escherichia coliQ74088698
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)110-117
P577publication date2010-10-11
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleStructural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor
P478volume55

Reverse relations

cites work (P2860)
Q36579058Characterization of Vibrio fluvialis qnrVC5 Gene in Native and Heterologous Hosts: Synergy of qnrVC5 with other Determinants in Conferring Quinolone Resistance
Q35191459Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach
Q30222873Dynamic cyanobacterial response to hydration and dehydration in a desert biological soil crust
Q34214929Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
Q41851848Functional verification of computationally predicted qnr genes.
Q55445576Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice.
Q42201141Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli.
Q36225422Mechanisms of drug resistance: quinolone resistance
Q36644818Mutational Analysis of Quinolone Resistance Protein QnrVC7 Provides Novel Insights into the Structure-Activity Relationship of Qnr Proteins
Q36757607Phylogenetic analysis of chromosomally determined qnr and related proteins
Q34888920Plasmid-mediated quinolone resistance
Q34019104Plasmidic qnrA3 enhances Escherichia coli fitness in absence of antibiotic exposure
Q34339689Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development.
Q33909989QnrS1 structure-activity relationships
Q38262589Squaring up to DNA: pentapeptide repeat proteins and DNA mimicry
Q27666560Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium
Q27667906Structure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance Factor
Q34237985The 1.7 Å resolution structure of At2g44920, a pentapeptide-repeat protein in the thylakoid lumen of Arabidopsis thaliana
Q92633491The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents
Q38906198Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance
Q49832269Topoisomerases as anticancer targets
Q97545721Type I beta turns make a new twist in pentapeptide repeat proteins: Crystal structure of Alr5209 from Nostoc sp. PCC 7120 determined at 1.7 angström resolution

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