review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | David C Hooper | |
George A Jacoby | |||
P2860 | cites work | NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump | Q24524231 |
Efflux-mediated drug resistance in bacteria: an update | Q24609407 | ||
DNA gyrase, topoisomerase IV, and the 4-quinolones | Q24643546 | ||
Mechanism of action of quinolones against Escherichia coli DNA gyrase | Q24681063 | ||
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands | Q27617911 | ||
Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance | Q27649912 | ||
Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡ | Q27651667 | ||
Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA | Q27653362 | ||
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases | Q27655501 | ||
Type IIA topoisomerase inhibition by a new class of antibacterial agents | Q27663884 | ||
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance | Q27664216 | ||
Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium | Q27666560 | ||
Structure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance Factor | Q27667906 | ||
Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport | Q27679776 | ||
A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of Inhibition | Q27681978 | ||
Structure of the AcrAB–TolC multidrug efflux pump | Q27683472 | ||
Crystal structure of the breakage-reunion domain of DNA gyrase | Q27742546 | ||
Molecular properties of bacterial multidrug transporters | Q28139376 | ||
A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus | Q28485591 | ||
Emergence of CTX-M-15-producing Klebsiella pneumoniae of multilocus sequence types 1, 11, 14, 17, 20, 35 and 36 as pathogens and colonizers in newborns and adults | Q84068375 | ||
RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations | Q36969955 | ||
Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period | Q37072043 | ||
qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin | Q37072053 | ||
Temporal appearance of plasmid-mediated quinolone resistance genes | Q37144821 | ||
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis | Q37190834 | ||
Mutational analysis of quinolone resistance protein QnrB1. | Q37263562 | ||
oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae | Q37274700 | ||
Risk factors and clinical characteristics of patients with qnr-positive Klebsiella pneumoniae bacteraemia | Q37286916 | ||
Quinolones: action and resistance updated | Q37595559 | ||
Mechanism of quinolone action and resistance | Q37701591 | ||
Plasmid-mediated 4-quinolone resistance: a real or apparent absence? | Q37936397 | ||
mvaT mutation modifies the expression of the Pseudomonas aeruginosa multidrug efflux operon mexEF-oprN. | Q38316292 | ||
Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1. | Q38741903 | ||
Description of an original integron encompassing blaVIM-2, qnrVC1 and genes encoding bacterial group II intron proteins in Pseudomonas aeruginosa | Q38901498 | ||
MepR, a repressor of the Staphylococcus aureus MATE family multidrug efflux pump MepA, is a substrate-responsive regulatory protein | Q39353191 | ||
Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae. | Q39469655 | ||
Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones | Q39470064 | ||
Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa | Q39470847 | ||
Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa | Q39475663 | ||
A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron | Q39479055 | ||
SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia | Q39479167 | ||
Active efflux of norfloxacin by Bacteroides fragilis | Q39559013 | ||
DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. | Q39559340 | ||
CmeABC functions as a multidrug efflux system in Campylobacter jejuni | Q39652330 | ||
Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyrase | Q39683413 | ||
In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump | Q39730607 | ||
Conjugative plasmid conferring resistance to olaquindox | Q39740621 | ||
Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases | Q39783230 | ||
Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. | Q39783715 | ||
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli | Q39816339 | ||
Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli. | Q39817311 | ||
Cloning and expression of the norA gene for fluoroquinolone resistance in Staphylococcus aureus | Q39819907 | ||
bmr3, a third multidrug transporter gene of Bacillus subtilis | Q39844656 | ||
Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr. | Q39845092 | ||
A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex | Q39864841 | ||
Posttranscriptional repression of Escherichia coli OmpF protein in response to redox stress: positive control of the micF antisense RNA by the soxRS locus | Q39884580 | ||
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli | Q40087129 | ||
Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coli | Q40286069 | ||
A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus | Q36153967 | ||
Protective effect of Qnr on agents other than quinolones that target DNA gyrase | Q36158288 | ||
Escherichia coli Mutants Thermosensitive for Deoxyribonucleic Acid Gyrase Subunit A: Effects on Deoxyribonucleic Acid Replication, Transcription, and Bacteriophage Growth | Q36311967 | ||
Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli | Q36439118 | ||
Mutagenesis and modeling to predict structural and functional characteristics of the Staphylococcus aureus MepA multidrug efflux pump | Q36559376 | ||
The Lactococcal lmrP Gene Encodes a Proton Motive Force- dependent Drug Transporter | Q36685361 | ||
qnr Gene nomenclature | Q36744808 | ||
Phylogenetic analysis of chromosomally determined qnr and related proteins | Q36757607 | ||
Quinolone-mediated bacterial death. | Q36921143 | ||
Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus | Q36958073 | ||
NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses. | Q36966916 | ||
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa | Q28492521 | ||
Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa | Q28492598 | ||
Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression | Q28492894 | ||
MexZ-mediated regulation of mexXY multidrug efflux pump expression in Pseudomonas aeruginosa by binding on the mexZ-mexX intergenic DNA | Q28493186 | ||
DNA topoisomerases | Q29619953 | ||
Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia | Q30944576 | ||
Phylogeny and Comparative Genomics Unveil Independent Diversification Trajectories of qnrB and Genetic Platforms within Particular Citrobacter Species. | Q30980054 | ||
Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus | Q31050150 | ||
Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA | Q32035273 | ||
NorA functions as a multidrug efflux protein in both cytoplasmic membrane vesicles and reconstituted proteoliposomes | Q33183378 | ||
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants | Q33369591 | ||
Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding | Q33556083 | ||
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase | Q33556397 | ||
Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC. | Q33695982 | ||
MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus | Q33716692 | ||
Topoisomerase IV is a target of quinolones in Escherichia coli | Q33724600 | ||
The mar regulon: multiple resistance to antibiotics and other toxic chemicals | Q33739371 | ||
Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin | Q33770013 | ||
Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus | Q33826193 | ||
QnrS1 structure-activity relationships | Q33909989 | ||
Selective targeting of topoisomerase IV and DNA gyrase in Staphylococcus aureus: different patterns of quinolone-induced inhibition of DNA synthesis | Q33980255 | ||
Genetic analyses of mutations contributing to fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae | Q33983643 | ||
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. | Q33987554 | ||
Mechanism of plasmid-mediated quinolone resistance | Q34025874 | ||
A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study. | Q34077206 | ||
The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes | Q34111927 | ||
Clinical use of the fluoroquinolones | Q34130062 | ||
Quinolones: from antibiotics to autoinducers | Q34133116 | ||
Overexpression of the novel MATE fluoroquinolone efflux pump FepA in Listeria monocytogenes is driven by inactivation of its local repressor FepR | Q34133831 | ||
Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. | Q34151135 | ||
Regulation of bacterial drug export systems | Q34300836 | ||
LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus | Q34309539 | ||
PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones | Q34403792 | ||
Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor | Q34483705 | ||
A novel method to discover fluoroquinolone antibiotic resistance (qnr) genes in fragmented nucleotide sequences. | Q34508578 | ||
NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus | Q34509802 | ||
qnrB, another plasmid-mediated gene for quinolone resistance | Q34510366 | ||
Efflux pump Lde is associated with fluoroquinolone resistance in Listeria monocytogenes | Q34820625 | ||
Clinical importance and epidemiology of quinolone resistance | Q34838791 | ||
Mechanisms of RND multidrug efflux pumps | Q34886484 | ||
Plasmid-mediated quinolone resistance | Q34888920 | ||
Implication of the NorB efflux pump in the adaptation of Staphylococcus aureus to growth at acid pH and in resistance to moxifloxacin | Q35065822 | ||
Mobile insertion cassette elements found in small non-transmissible plasmids in Proteeae may explain qnrD mobilization | Q35087905 | ||
In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor | Q35113781 | ||
Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus. | Q35126142 | ||
Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. | Q35131579 | ||
Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa. | Q35139043 | ||
AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity. | Q35212722 | ||
AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity | Q35226455 | ||
Molecular epidemiology and genetic diversity of fluoroquinolone-resistant Escherichia coli isolates from patients with community-onset infections in 30 Chinese county hospitals | Q35331113 | ||
Citrobacter spp. as a source of qnrB Alleles | Q35364333 | ||
Characterization of Tn6238 with a new allele of aac(6')-Ib-cr | Q35385866 | ||
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria | Q35482558 | ||
Transcriptional profiling analysis of the global regulator NorG, a GntR-like protein of Staphylococcus aureus | Q35530922 | ||
EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB. | Q35584121 | ||
Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA | Q35598367 | ||
Transcriptional activation of promoters of the superoxide and multiple antibiotic resistance regulons by Rob, a binding protein of the Escherichia coli origin of chromosomal replication | Q35606299 | ||
Evolution and dissemination of OqxAB-like efflux pumps, an emerging quinolone resistance determinant among members of Enterobacteriaceae | Q35607632 | ||
Efflux-mediated drug resistance in bacteria | Q35626332 | ||
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance | Q35682250 | ||
In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groups | Q35758905 | ||
The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus | Q35759598 | ||
Reduced aeration affects the expression of the NorB efflux pump of Staphylococcus aureus by posttranslational modification of MgrA. | Q35826704 | ||
Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli | Q35879095 | ||
Interactions between QnrB, QnrB mutants, and DNA gyrase | Q35960942 | ||
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate | Q36094929 | ||
Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon | Q36123973 | ||
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus | Q40286293 | ||
Apparent absence of transferable resistance to nalidixic acid in pathogenic Gram-negative bacteria | Q40810533 | ||
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. | Q41008865 | ||
Identification and characterization of porins in Pseudomonas aeruginosa | Q41138048 | ||
Contribution of resistance-nodulation-cell division efflux systems to antibiotic resistance and biofilm formation in Acinetobacter baumannii. | Q41168091 | ||
Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus | Q41789997 | ||
Rat/MgrA, a regulator of autolysis, is a regulator of virulence genes in Staphylococcus aureus | Q41899843 | ||
New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1 | Q41970495 | ||
Description of a 2,683-base-pair plasmid containing qnrD in two Providencia rettgeri isolates | Q42000683 | ||
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture Collection | Q42110249 | ||
Origin of plasmid-mediated quinolone resistance determinant QnrA. | Q42112652 | ||
Vibrionaceae as a possible source of Qnr-like quinolone resistance determinants | Q42670804 | ||
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1. | Q42747648 | ||
Triclosan can select for an AdeIJK-overexpressing mutant of Acinetobacter baumannii ATCC 17978 that displays reduced susceptibility to multiple antibiotics | Q43045764 | ||
Analyses of multidrug efflux pump-like proteins encoded on the Staphylococcus aureus chromosome. | Q43102378 | ||
High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria | Q43215491 | ||
Antibiotic inducibility of the mexXY multidrug efflux operon of Pseudomonas aeruginosa: involvement of the MexZ anti-repressor ArmZ. | Q43245264 | ||
1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. | Q43498212 | ||
The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus | Q43674786 | ||
The Glu-84 of the ParC subunit plays critical roles in both topoisomerase IV-quinolone and topoisomerase IV-DNA interactions | Q44148098 | ||
The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204. | Q44275319 | ||
Qnr-like pentapeptide repeat proteins in gram-positive bacteria | Q44351734 | ||
Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. | Q44468465 | ||
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family. | Q45923057 | ||
High levels of multidrug resistance in clinical isolates of Gram-negative pathogens from Nigeria | Q46157116 | ||
Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake | Q46388921 | ||
Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by Klebsiella pneumoniae deficient in porins, expressing active efflux and producing QnrA1. | Q46536125 | ||
Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes | Q46714399 | ||
The mechanism of inhibition of topoisomerase IV by quinolone antibacterials | Q46829877 | ||
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase | Q46862305 | ||
Gene cloning and characterization of SdrM, a chromosomally-encoded multidrug efflux pump, from Staphylococcus aureus | Q46969042 | ||
Prevalence and plasmid characterization of the qnrD determinant in Enterobacteriaceae isolated from animals, retail meat products, and humans | Q48040016 | ||
A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium | Q48070197 | ||
Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria | Q50071728 | ||
Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli. | Q53939108 | ||
The complex of DNA gyrase and quinolone drugs on DNA forms a barrier to the T7 DNA polymerase replication complex. | Q54026212 | ||
Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa. | Q54027874 | ||
Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance. | Q54127765 | ||
Quinolone resistance from a transferable plasmid. | Q54143628 | ||
The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase. | Q54194852 | ||
Occurrence of virulence genes, 16S rRNA methylases, and plasmid-mediated quinolone resistance genes in CTX-M-producing Escherichia coli from Pakistan. | Q54243354 | ||
Protein- and RNA-synthesis independent bactericidal activity of ciprofloxacin that involves the A subunit of DNA gyrase | Q54308976 | ||
Impact of low-level fluoroquinolone resistance genes qnrA1, qnrB19 and qnrS1 on ciprofloxacin treatment of isogenic Escherichia coli strains in a murine urinary tract infection model. | Q54334733 | ||
Bloodstream infections caused by qnr-positive Enterobacteriaceae: clinical and microbiologic characteristics and outcomes. | Q54437233 | ||
Therapeutic effect of a new antibacterial substance ofloxacin (DL8280) on pulmonary tuberculosis. | Q54454249 | ||
DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex. | Q54578886 | ||
4-Quinolone bactericidal mechanisms. | Q54650965 | ||
Contribution of OqxAB efflux pumps to quinolone resistance in extended-spectrum- -lactamase-producing Klebsiella pneumoniae | Q59617399 | ||
An ABC-type multidrug transporter of Lactococcus lactis possesses an exceptionally broad substrate specificity | Q63387756 | ||
Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes | Q69327780 | ||
Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa | Q73626080 | ||
Epidemiology and mechanism of antibiotic resistance in Helicobacter pylori | Q77494299 | ||
An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus | Q80277901 | ||
P433 | issue | 9 | |
P577 | publication date | 2016-07-22 | |
P1433 | published in | Cold Spring Harbor Perspectives in Medicine | Q21042440 |
P1476 | title | Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance | |
P478 | volume | 6 |
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