Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance

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Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1101/CSHPERSPECT.A025320
P932PMC publication ID5008060
P698PubMed publication ID27449972

P2093author name stringDavid C Hooper
George A Jacoby
P2860cites workNorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pumpQ24524231
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Type IIA topoisomerase inhibition by a new class of antibacterial agentsQ27663884
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Structure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance FactorQ27667906
Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transportQ27679776
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Mechanism of quinolone action and resistanceQ37701591
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MepR, a repressor of the Staphylococcus aureus MATE family multidrug efflux pump MepA, is a substrate-responsive regulatory proteinQ39353191
Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.Q39469655
Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolonesQ39470064
Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosaQ39470847
Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosaQ39475663
A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicronQ39479055
SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophiliaQ39479167
Active efflux of norfloxacin by Bacteroides fragilisQ39559013
DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.Q39559340
CmeABC functions as a multidrug efflux system in Campylobacter jejuniQ39652330
Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyraseQ39683413
In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pumpQ39730607
Conjugative plasmid conferring resistance to olaquindoxQ39740621
Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerasesQ39783230
Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.Q39783715
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coliQ39816339
Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli.Q39817311
Cloning and expression of the norA gene for fluoroquinolone resistance in Staphylococcus aureusQ39819907
bmr3, a third multidrug transporter gene of Bacillus subtilisQ39844656
Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr.Q39845092
A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complexQ39864841
Posttranscriptional repression of Escherichia coli OmpF protein in response to redox stress: positive control of the micF antisense RNA by the soxRS locusQ39884580
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coliQ40087129
Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coliQ40286069
A novel locus conferring fluoroquinolone resistance in Staphylococcus aureusQ36153967
Protective effect of Qnr on agents other than quinolones that target DNA gyraseQ36158288
Escherichia coli Mutants Thermosensitive for Deoxyribonucleic Acid Gyrase Subunit A: Effects on Deoxyribonucleic Acid Replication, Transcription, and Bacteriophage GrowthQ36311967
Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coliQ36439118
Mutagenesis and modeling to predict structural and functional characteristics of the Staphylococcus aureus MepA multidrug efflux pumpQ36559376
The Lactococcal lmrP Gene Encodes a Proton Motive Force- dependent Drug TransporterQ36685361
qnr Gene nomenclatureQ36744808
Phylogenetic analysis of chromosomally determined qnr and related proteinsQ36757607
Quinolone-mediated bacterial death.Q36921143
Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureusQ36958073
NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses.Q36966916
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosaQ28492521
Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosaQ28492598
Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expressionQ28492894
MexZ-mediated regulation of mexXY multidrug efflux pump expression in Pseudomonas aeruginosa by binding on the mexZ-mexX intergenic DNAQ28493186
DNA topoisomerasesQ29619953
Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophiliaQ30944576
Phylogeny and Comparative Genomics Unveil Independent Diversification Trajectories of qnrB and Genetic Platforms within Particular Citrobacter Species.Q30980054
Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureusQ31050150
Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpAQ32035273
NorA functions as a multidrug efflux protein in both cytoplasmic membrane vesicles and reconstituted proteoliposomesQ33183378
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinantsQ33369591
Fluoroquinolone-gyrase-DNA complexes: two modes of drug bindingQ33556083
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyraseQ33556397
Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC.Q33695982
MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureusQ33716692
Topoisomerase IV is a target of quinolones in Escherichia coliQ33724600
The mar regulon: multiple resistance to antibiotics and other toxic chemicalsQ33739371
Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacinQ33770013
Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureusQ33826193
QnrS1 structure-activity relationshipsQ33909989
Selective targeting of topoisomerase IV and DNA gyrase in Staphylococcus aureus: different patterns of quinolone-induced inhibition of DNA synthesisQ33980255
Genetic analyses of mutations contributing to fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniaeQ33983643
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.Q33987554
Mechanism of plasmid-mediated quinolone resistanceQ34025874
A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.Q34077206
The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenesQ34111927
Clinical use of the fluoroquinolonesQ34130062
Quinolones: from antibiotics to autoinducersQ34133116
Overexpression of the novel MATE fluoroquinolone efflux pump FepA in Listeria monocytogenes is driven by inactivation of its local repressor FepRQ34133831
Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment.Q34151135
Regulation of bacterial drug export systemsQ34300836
LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureusQ34309539
PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolonesQ34403792
Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitorQ34483705
A novel method to discover fluoroquinolone antibiotic resistance (qnr) genes in fragmented nucleotide sequences.Q34508578
NorC, a new efflux pump regulated by MgrA of Staphylococcus aureusQ34509802
qnrB, another plasmid-mediated gene for quinolone resistanceQ34510366
Efflux pump Lde is associated with fluoroquinolone resistance in Listeria monocytogenesQ34820625
Clinical importance and epidemiology of quinolone resistanceQ34838791
Mechanisms of RND multidrug efflux pumpsQ34886484
Plasmid-mediated quinolone resistanceQ34888920
Implication of the NorB efflux pump in the adaptation of Staphylococcus aureus to growth at acid pH and in resistance to moxifloxacinQ35065822
Mobile insertion cassette elements found in small non-transmissible plasmids in Proteeae may explain qnrD mobilizationQ35087905
In vitro evaluation of ABT-719, a novel DNA gyrase inhibitorQ35113781
Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.Q35126142
Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.Q35131579
Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa.Q35139043
AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.Q35212722
AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificityQ35226455
Molecular epidemiology and genetic diversity of fluoroquinolone-resistant Escherichia coli isolates from patients with community-onset infections in 30 Chinese county hospitalsQ35331113
Citrobacter spp. as a source of qnrB AllelesQ35364333
Characterization of Tn6238 with a new allele of aac(6')-Ib-crQ35385866
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteriaQ35482558
Transcriptional profiling analysis of the global regulator NorG, a GntR-like protein of Staphylococcus aureusQ35530922
EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.Q35584121
Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrAQ35598367
Transcriptional activation of promoters of the superoxide and multiple antibiotic resistance regulons by Rob, a binding protein of the Escherichia coli origin of chromosomal replicationQ35606299
Evolution and dissemination of OqxAB-like efflux pumps, an emerging quinolone resistance determinant among members of EnterobacteriaceaeQ35607632
Efflux-mediated drug resistance in bacteriaQ35626332
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistanceQ35682250
In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groupsQ35758905
The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureusQ35759598
Reduced aeration affects the expression of the NorB efflux pump of Staphylococcus aureus by posttranslational modification of MgrA.Q35826704
Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coliQ35879095
Interactions between QnrB, QnrB mutants, and DNA gyraseQ35960942
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolateQ36094929
Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operonQ36123973
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureusQ40286293
Apparent absence of transferable resistance to nalidixic acid in pathogenic Gram-negative bacteriaQ40810533
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.Q41008865
Identification and characterization of porins in Pseudomonas aeruginosaQ41138048
Contribution of resistance-nodulation-cell division efflux systems to antibiotic resistance and biofilm formation in Acinetobacter baumannii.Q41168091
Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureusQ41789997
Rat/MgrA, a regulator of autolysis, is a regulator of virulence genes in Staphylococcus aureusQ41899843
New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1Q41970495
Description of a 2,683-base-pair plasmid containing qnrD in two Providencia rettgeri isolatesQ42000683
Characterization of qnrB-like genes in Citrobacter species of the American Type Culture CollectionQ42110249
Origin of plasmid-mediated quinolone resistance determinant QnrA.Q42112652
Vibrionaceae as a possible source of Qnr-like quinolone resistance determinantsQ42670804
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.Q42747648
Triclosan can select for an AdeIJK-overexpressing mutant of Acinetobacter baumannii ATCC 17978 that displays reduced susceptibility to multiple antibioticsQ43045764
Analyses of multidrug efflux pump-like proteins encoded on the Staphylococcus aureus chromosome.Q43102378
High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in BulgariaQ43215491
Antibiotic inducibility of the mexXY multidrug efflux operon of Pseudomonas aeruginosa: involvement of the MexZ anti-repressor ArmZ.Q43245264
1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS.Q43498212
The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureusQ43674786
The Glu-84 of the ParC subunit plays critical roles in both topoisomerase IV-quinolone and topoisomerase IV-DNA interactionsQ44148098
The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204.Q44275319
Qnr-like pentapeptide repeat proteins in gram-positive bacteriaQ44351734
Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein.Q44468465
Epidemiology of qnrVC alleles and emergence out of the Vibrionaceae family.Q45923057
High levels of multidrug resistance in clinical isolates of Gram-negative pathogens from NigeriaQ46157116
Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lakeQ46388921
Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by Klebsiella pneumoniae deficient in porins, expressing active efflux and producing QnrA1.Q46536125
Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genesQ46714399
The mechanism of inhibition of topoisomerase IV by quinolone antibacterialsQ46829877
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferaseQ46862305
Gene cloning and characterization of SdrM, a chromosomally-encoded multidrug efflux pump, from Staphylococcus aureusQ46969042
Prevalence and plasmid characterization of the qnrD determinant in Enterobacteriaceae isolated from animals, retail meat products, and humansQ48040016
A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimuriumQ48070197
Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteriaQ50071728
Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli.Q53939108
The complex of DNA gyrase and quinolone drugs on DNA forms a barrier to the T7 DNA polymerase replication complex.Q54026212
Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa.Q54027874
Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance.Q54127765
Quinolone resistance from a transferable plasmid.Q54143628
The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase.Q54194852
Occurrence of virulence genes, 16S rRNA methylases, and plasmid-mediated quinolone resistance genes in CTX-M-producing Escherichia coli from Pakistan.Q54243354
Protein- and RNA-synthesis independent bactericidal activity of ciprofloxacin that involves the A subunit of DNA gyraseQ54308976
Impact of low-level fluoroquinolone resistance genes qnrA1, qnrB19 and qnrS1 on ciprofloxacin treatment of isogenic Escherichia coli strains in a murine urinary tract infection model.Q54334733
Bloodstream infections caused by qnr-positive Enterobacteriaceae: clinical and microbiologic characteristics and outcomes.Q54437233
Therapeutic effect of a new antibacterial substance ofloxacin (DL8280) on pulmonary tuberculosis.Q54454249
DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex.Q54578886
4-Quinolone bactericidal mechanisms.Q54650965
Contribution of OqxAB efflux pumps to quinolone resistance in extended-spectrum- -lactamase-producing Klebsiella pneumoniaeQ59617399
An ABC-type multidrug transporter of Lactococcus lactis possesses an exceptionally broad substrate specificityQ63387756
Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexesQ69327780
Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosaQ73626080
Epidemiology and mechanism of antibiotic resistance in Helicobacter pyloriQ77494299
An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureusQ80277901
P433issue9
P577publication date2016-07-22
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleTopoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance
P478volume6

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