Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡

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Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡ is …
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scholarly articleQ13442814

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P356DOI10.1021/BI800664X
P3181OpenCitations bibliographic resource ID1825000
P932PMC publication ID2855648
P698PubMed publication ID18710261
P5875ResearchGate publication ID23177609

P50authorJohn S BlanchardQ89141307
George A JacobyQ104979117
P2093author name stringMatthew W Vetting
Subray S Hegde
David C Hooper
Chi Hye Park
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The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transferQ38358019
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Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativityQ44454184
Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivationQ44724468
Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescensQ46337932
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P433issue37
P407language of work or nameEnglishQ1860
P304page(s)9825-35
P577publication date2008-09-16
P1433published inBiochemistryQ764876
P1476titleMechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡
P478volume47

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