Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance

scientific article

Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOR.2008.9
P3181OpenCitations bibliographic resource ID4731784
P932PMC publication ID2288771
P698PubMed publication ID18292754
P5875ResearchGate publication ID232788155

P2093author name stringEkkehard Collatz
Frédéric Dardel
Frédérique Maurice
Isabelle Broutin
Isabelle Podglajen
Philippe Benas
P2860cites workImproved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily foldQ27618744
Use of TLS parameters to model anisotropic displacements in macromolecular refinementQ27860499
PRODRG: a tool for high-throughput crystallography of protein-ligand complexesQ27860633
The Xplor-NIH NMR molecular structure determination packageQ27860805
Pushing the boundaries of molecular replacement with maximum likelihoodQ27860922
Structure and functions of the GNAT superfamily of acetyltransferasesQ28296840
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constantsQ29546524
Optimisation of a peptide library for screening specific RNA ligands by flow-injection NMR.Q31120473
Aminoglycoside 6'-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii.Q33689302
The worldwide emergence of plasmid-mediated quinolone resistanceQ34569740
Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faeciumQ35135819
Versatility of aminoglycosides and prospects for their futureQ35176271
Resistance integrons and super-integronsQ35732086
Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptorQ38299722
Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosaQ38302896
Salmonella enterica serovar Typhimurium bla(PER-1)-carrying plasmid pSTI1 encodes an extended-spectrum aminoglycoside 6'-N-acetyltransferase of type Ib.Q39740503
Primary structure of an aminoglycoside 6'-N-acetyltransferase AAC(6')-4, fused in vivo with the signal peptide of the Tn3-encoded beta-lactamaseQ39963396
Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferaseQ43571417
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferaseQ46862305
A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histonesQ47659801
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectantibiotic resistanceQ380775
P304page(s)344-9
P577publication date2008-04-01
P1433published inEMBO ReportsQ5323356
P1476titleEnzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance
P478volume9

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cites work (P2860)
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Q30370754Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments.
Q41838457Effects of altering aminoglycoside structures on bacterial resistance enzyme activities
Q35955677Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking
Q36225422Mechanisms of drug resistance: quinolone resistance
Q27651667Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡
Q46965268Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex
Q54941501Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory.
Q90636536Palmatine Is a Plasmid-Mediated Quinolone Resistance (PMQR) Inhibitor That Restores the Activity of Ciprofloxacin Against QnrS and AAC(6')-Ib-cr-Producing Escherichia coli
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Q90732911Small Klebsiella pneumoniae Plasmids: Neglected Contributors to Antibiotic Resistance
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Q34483705Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor
Q26314426Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)
Q34299292Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis
Q36954344Synonymous genes explore different evolutionary landscapes.
Q37144821Temporal appearance of plasmid-mediated quinolone resistance genes
Q30393373The Genomic Enzymology of Antibiotic Resistance
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Q37528001Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase
Q27668103Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB

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