Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

scientific article published on 20 December 2005

Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NM1347
P698PubMed publication ID16369542
P5875ResearchGate publication ID7400496

P50authorGeorge A JacobyQ104979117
Jacob StrahilevitzQ104980952
Ari RobicsekQ104982006
P2093author name stringDavid C Hooper
Karen Bush
Mark Macielag
Darren Abbanat
Chi Hye Park
P2860cites workEmerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United StatesQ37121208
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, CanadaQ37568365
Prevention of drug access to bacterial targets: permeability barriers and active effluxQ40737334
Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic bindingQ42865460
Surveillance of bacterial resistance among isolates in Shanghai in 1999.Q43676002
A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histonesQ47659801
Class I integrons in Gram-negative isolates from different European hospitals and association with decreased susceptibility to multiple antibiotic compoundsQ74533257
Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding siteQ27729332
Structure-activity and structure-side-effect relationships for the quinolone antibacterialsQ28246405
Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: identification of metabolitesQ28254007
Broader distribution of plasmid-mediated quinolone resistance in the United StatesQ33883639
Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use.Q34177418
Macrolide resistance mechanisms in Gram-positive cocciQ34382800
Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, ChinaQ35102456
Molecular cloning of amikacin resistance determinants from a Klebsiella pneumoniae plasmidQ35651704
Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitroQ35821472
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)83-88
P577publication date2005-12-20
P1433published inNature MedicineQ1633234
P1476titleFluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
P478volume12

Reverse relations

cites work (P2860)
Q92953635A Novel VIM-Type Metallo-β-Lactamase Variant, VIM-60, with Increased Hydrolyzing Activity against Fourth-Generation Cephalosporins in Pseudomonas aeruginosa Clinical Isolates in Japan
Q92228995A large self-transmissible resistance plasmid from Nigeria contains genes that ameliorate a carrying cost
Q41341125A plasmid-borne Shewanella algae Gene, qnrA3, and its possible transfer in vivo between Kluyvera ascorbata and Klebsiella pneumoniae
Q38635832A population genomics approach to exploiting the accessory 'resistome' of Escherichia coli
Q36684164Accurate detection of Neisseria gonorrhoeae ciprofloxacin susceptibility directly from genital and extragenital clinical samples: towards genotype-guided antimicrobial therapy.
Q35451219Acquired antibiotic resistance genes: an overview.
Q52744431Amikacin: Uses, Resistance, and Prospects for Inhibition.
Q34354185Aminoglycoside modifying enzymes
Q38851189Aminoglycosides: An Overview
Q36669328Aminoglycosides: ancient and modern
Q91788081An overview of the antimicrobial resistance mechanisms of bacteria
Q28481714Analysis of drug resistance determinants in Klebsiella pneumoniae isolates from a tertiary-care hospital in Beijing, China
Q42861089Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance
Q37704177Antibiotic resistance and its cost: is it possible to reverse resistance?
Q34432199Antibiotic-resistant Escherichia coli bacteria, including strains with genes encoding the extended-spectrum beta-lactamase and QnrS, in waterbirds on the Baltic Sea Coast of Poland
Q58572910Antimicrobial Resistance Profile of Positive Clinical Isolates of in China From 2013 to 2016
Q37723418Antimicrobial Resistance of Salmonella enterica Serovar Typhimurium in Shanghai, China
Q37072303Antimicrobial drug-selection markers for Burkholderia pseudomallei and B. mallei
Q64997811Antimicrobial resistance and genetic characterization of Shigella spp. in Shanxi Province, China, during 2006-2016.
Q40640481Antimicrobial resistance genes in marine bacteria and human uropathogenic Escherichia coli from a region of intensive aquaculture.
Q36771609Antimicrobial resistance in nontyphoidal Salmonella.
Q35147101Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections
Q34742045Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health.
Q39960096Antimicrobials: past, present and uncertain future
Q33771873Assessing sensitivity to antibacterial topoisomerase II inhibitors
Q42247522Assessing the molecular basis of transferable quinolone resistance in Escherichia coli and Salmonella spp. from food-producing animals and food products
Q33836471Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.
Q26773344Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation
Q37588992Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China
Q42574879CTX-M as the predominant extended-spectrum beta-lactamases among Enterobacteriaceae in Manila, Philippines
Q46283648CTX-M-15-producing Shewanella sp. clinical isolate expressing OXA-535, a chromosome-encoded OXA-48 variant, putative progenitor of the plasmid-encoded OXA-436.
Q43169864Changes in aac(6')-Ib-cr prevalence and fluoroquinolone resistance in nosocomial isolates of Escherichia coli collected from 1991 through 2005.
Q40600967Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6')-Ib-cr gene.
Q42037165Characteristics of NDM-1-producing Escherichia coli isolates that belong to the successful and virulent clone ST131.
Q92051378Characterization of Mechanisms Lowering Susceptibility to Flumequine among Bacteria Isolated from Chilean Salmonid Farms
Q46264520Characterization of Salmonella enterica isolates from infants and toddlers in Wuhan, China
Q35385866Characterization of Tn6238 with a new allele of aac(6')-Ib-cr
Q48523920Characterization of an Outbreak of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit in Italy
Q35023502Characterization of plasmid-mediated quinolone resistance (PMQR) genes in extended-spectrum β-lactamase-producing Enterobacteriaceae pediatric clinical isolates in Mexico
Q43954438Characterization of plasmids harbouring qnrS1, qnrB2 and qnrB19 genes in Salmonella
Q35555287Chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms among broad-spectrum-cephalosporin-resistant Escherichia coli isolates recovered from companion animals in the USA
Q52679373Ciprofloxacin degradation in anaerobic sulfate-reducing bacteria (SRB) sludge system: Mechanism and pathways.
Q37335894Ciprofloxacin treatment failure in a murine model of pyelonephritis due to an AAC(6')-Ib-cr-producing Escherichia coli strain susceptible to ciprofloxacin in vitro.
Q43003072Ciprofloxacin-resistant enterobacteria harboring the aac(6')-Ib-cr variant isolated from feces of inpatients in an intensive care unit in Uruguay
Q35364333Citrobacter spp. as a source of qnrB Alleles
Q42198419Class 1 integrons in resistant Escherichia coli and Klebsiella spp., US hospitals
Q34838791Clinical importance and epidemiology of quinolone resistance
Q28246841Clinical management of infections caused by multidrug-resistant Enterobacteriaceae
Q90795637Clonal relatedness of Proteus mirabilis strains causing urinary tract infections in companion animals and humans
Q54332809Co-production of SFO-1 and DHA-1 β-lactamases and 16S rRNA methylase ArmA in clinical isolates of Klebsiella pneumoniae.
Q54337093Coexistence of blaOXA-48 and aac(6')-Ib-cr genes in Klebsiella pneumoniae isolates from Istanbul, Turkey.
Q36233864Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation
Q36726208Collective antibiotic tolerance: mechanisms, dynamics and intervention
Q48053355Comment on: Resistance gene naming and numbering: is it a new gene or not?
Q34541597Comparable high rates of extended-spectrum-beta-lactamase-producing Escherichia coli in birds of prey from Germany and Mongolia
Q35816979Comparison of the prevalences and antimicrobial resistances of Escherichia coli isolates from different retail meats in the United States, 2002 to 2008
Q36313202Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina
Q37190784Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance
Q42355473Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs
Q36960068Current concepts in antibiotic-resistant gram-negative bacteria
Q90258921DNA Damage Repair and Drug Efflux as Potential Targets for Reversing Low or Intermediate Ciprofloxacin Resistance in E. coli K-12
Q94464343Deadly Puppy Infection Caused by an MDR Escherichia coli O39 bla CTX-M-15, bla CMY-2, bla DHA-1, and aac(6)-Ib-cr - Positive in a Breeding Kennel in Central Italy
Q34737591Decreased susceptibility to ciprofloxacin among Shigella isolates in the United States, 2006 to 2009.
Q26824268Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy
Q89907735Detection of Chromosomal and Plasmid-Mediated Quinolone Resistance Among Escherichia coli Isolated from Urinary Tract Infection Cases; Zagazig University Hospitals, Egypt
Q37256426Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
Q53692302Detection of plasmid-mediated quinolone resistance in clinical isolates of Enterobacteriaceae strains in Hamadan, West of Iran.
Q43215478Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog.
Q44716329Detection of three stable genetic clones of CTX-M-15-producing Klebsiella pneumoniae in the Barcelona metropolitan area, Spain
Q36173968Development of a Pefloxacin Disk Diffusion Method for Detection of Fluoroquinolone-Resistant Salmonella enterica
Q37026587Differential distribution of plasmid-mediated quinolone resistance genes in clinical enterobacteria with unusual phenotypes of quinolone susceptibility from Argentina.
Q34264500Differential epigenetic compatibility of qnr antibiotic resistance determinants with the chromosome of Escherichia coli.
Q60951787Discovery of Potential Plant-Derived Peptide Deformylase (PDF) Inhibitors for Multidrug-Resistant Bacteria Using Computational Studies
Q42002757Discrimination between native and Tn6010-associated oqxAB in Klebsiella spp., Raoultella spp., and other Enterobacteriaceae by using a two-step strategy
Q34989526Dissemination and characterization of plasmids carrying oqxAB-bla CTX-M genes in Escherichia coli isolates from food-producing animals
Q43151557Dissemination in Portugal of CTX-M-15-, OXA-1-, and TEM-1-producing Enterobacteriaceae strains containing the aac(6')-Ib-cr gene, which encodes an aminoglycoside- and fluoroquinolone-modifying enzyme
Q92739401Dissemination of Quinolone-Resistant Escherichia coli in the Norwegian Broiler and Pig Production Chains and Possible Persistence in the Broiler Production Environment
Q37531253Dissemination of ST274 Klebsiella pneumoniae epidemic clone in newborn and adult hospital settings harbouring SHV-2A or CTX-M-15 type extended spectrum β-lactamases-producing known plasmids
Q42111230Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15.
Q35362083Dissemination of the transmissible quinolone-resistance gene qnrS1 by IncX plasmids in Nigeria
Q89529565Distribution of Medically Relevant Antibiotic Resistance Genes and Mobile Genetic Elements in Soils of Temperate Forests and Grasslands Varying in Land Use
Q42213355Diversity of extended-spectrum and plasmid-mediated AmpC β-lactamases in Enterobacteriaceae isolates from Portuguese health care facilities.
Q97418485Efficacy of Acacia nilotica aqueous extract in treating biofilm-forming and multidrug resistant uropathogens isolated from patients with UTI syndrome
Q37144908Efficacy of ciprofloxacin in an experimental model of Escherichia coli chorioamnionitis in rabbits
Q24609407Efflux-mediated drug resistance in bacteria: an update
Q41894204Emergence of Proteus mirabilis harboring blaKPC-2 and qnrD in a Chinese Hospital.
Q33593668Emergence of and risk factors for ciprofloxacin-gentamicin-resistant Escherichia coli urinary tract infections in a region of Quebec
Q37190695Emergence of plasmid-mediated quinolone resistance among non-Typhi Salmonella enterica isolates from humans in the United States
Q42090917Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-beta-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005
Q91951403Emerging coexistence of three PMQR genes on a multiple resistance plasmid with a new surrounding genetic structure of qnrS2 in E. coli in China
Q27649912Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance
Q30396308Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain
Q91611002Etiology of childhood diarrhoea among under five children and molecular analysis of antibiotic resistance in isolated enteric bacterial pathogens from a tertiary care hospital, Eastern Odisha, India
Q43214932Evaluation of Surrogate Disk Tests for Detection of Ciprofloxacin and Levofloxacin Resistance in Clinical Isolates of Salmonella enterica
Q62635883Evaluation of quinolones for use in detection of determinants of acquired quinolone resistance, including the new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6')Ib-cr, in Escherichia coli and Salmonella enterica and determinations o
Q42643928Existence of a novel qepA variant in quinolone resistant Escherichia coli from aquatic habitats of Bangladesh
Q42358852Expression of the aac(6')-Ib-cr Gene in Class 1 Integrons
Q35840844External guide sequences targeting the aac(6')-Ib mRNA induce inhibition of amikacin resistance
Q35758827First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America
Q50047143Fitness tradeoffs of antibiotic resistance in extra-intestinal pathogenic Escherichia coli
Q36173899Fluoroquinolone Resistance in Salmonella and the Utility of Pefloxacin Disk Diffusion [corrected].
Q42086224Frequency of conjugative transfer of plasmid-encoded ISEcp1 - blaCTX-M-15 and aac(6')-lb-cr genes in Enterobacteriaceae at a tertiary care center in Lebanon - role of transferases
Q35989920Frequency, Antimicrobial Resistance and Genetic Diversity of Klebsiella pneumoniae in Food Samples
Q34494097Frequent combination of antimicrobial multiresistance and extraintestinal pathogenicity in Escherichia coli isolates from urban rats (Rattus norvegicus) in Berlin, Germany
Q37470852Gene cassettes and cassette arrays in mobile resistance integrons.
Q38863458Genetic analysis of antimicrobial resistance in Escherichia coli isolated from diarrheic neonatal calves.
Q38852673Genetic background of quinolone resistance in CTX-M-15-producing Klebsiella pneumonia and Escherichia coli strains in Tunisia
Q40263075Genetic characterization of fluoroquinolone resistant Escherichia coli from urban streams and municipal and hospital effluents.
Q36664824Genetics of antimicrobial resistance
Q101476231Genotypic antimicrobial resistance characterization of E. coli from dairy calves at high risk of respiratory disease administered enrofloxacin or tulathromycin
Q39296769Genotypic characterization of quinolone resistant-Escherichia coli isolates from retail food in Morocco.
Q39581862Global DNA Methylation Level among Ciprofloxacin-Resistant Clinical Isolates of Escherichia coli
Q36095081Global challenge of multidrug-resistant Acinetobacter baumannii
Q36337074Global fluoroquinolone resistance epidemiology and implictions for clinical use.
Q36969763Gram-negative bacteria that produce carbapenemases causing death attributed to recent foreign hospitalization
Q30378612Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131.
Q36526009Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment
Q36881079High incidence of plasmid-mediated quinolone resistance genes among ciprofloxacin-resistant clinical isolates of Enterobacteriaceae at a tertiary care hospital in Puducherry, India
Q37072029High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals
Q41388247High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China
Q39992753High prevalence of qnr and aac(6')-Ib-cr genes in both water-borne environmental bacteria and clinical isolates of Citrobacter freundii in China.
Q43215491High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria
Q54198024High rate of aminoglycoside resistance in CTX-M-15 producing Klebsiella pneumoniae isolates in Tehran, Iran.
Q42577243High-resolution melt curve analysis for identification of single nucleotide mutations in the quinolone resistance gene aac(6')-Ib-cr
Q41336639ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli
Q40103257Identification of Plasmid-Mediated Quinolone Resistance in Salmonella Isolated from Swine Ceca and Retail Pork Chops in the United States
Q43207261Identification of Qnr and AAC(6')-1b-cr plasmid-mediated fluoroquinolone resistance determinants in multidrug-resistant Enterobacter spp. isolated from extraintestinal infections in companion animals
Q43329584Identification of biotransformation products of macrolide and fluoroquinolone antimicrobials in membrane bioreactor treatment by ultrahigh-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Q36505966Identification of the enzyme responsible for N-acetylation of norfloxacin by Microbacterium sp. Strain 4N2-2.
Q40587123Impact of AAC(6')-Ib-cr in combination with chromosomal-mediated mechanisms on clinical quinolone resistance in Escherichia coli.
Q37392904Impact of low-level resistance to fluoroquinolones due to qnrA1 and qnrS1 genes or a gyrA mutation on ciprofloxacin bactericidal activity in a murine model of Escherichia coli urinary tract infection
Q51153258Impact of plasmid-borne oqxAB on the development of fluoroquinolone resistance and bacterial fitness in Escherichia coli.
Q83006155In vitro enrofloxacin binding in human fecal slurries
Q35807773Indirect resistance to several classes of antibiotics in cocultures with resistant bacteria expressing antibiotic-modifying or -degrading enzymes
Q37694529Infections with extended-spectrum beta-lactamase-producing enterobacteriaceae: changing epidemiology and drug treatment choices
Q34980567Inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] identified by in silico molecular docking
Q41220729Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli
Q50043202International collaborative study on the occurrence of plasmid-mediated quinolone resistance in Salmonella enterica and Escherichia coli isolated from animals, humans, food and the environment in 13 European countries
Q42201141Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli.
Q37471259Intraclonal Genome Stability of the Metallo-β-lactamase SPM-1-producing Pseudomonas aeruginosa ST277, an Endemic Clone Disseminated in Brazilian Hospitals.
Q43914864Joint Effects of Topoisomerase Alterations and Plasmid-Mediated Quinolone-Resistant Determinants inSalmonella entericaTyphimurium
Q41079534Lack of antimicrobial bactericidal activity in Mycobacterium abscessus.
Q38101380Levofloxacin for the treatment of pyelonephritis
Q34057563Long-term dissemination of CTX-M-5-producing hypermutable Salmonella enterica serovar typhimurium sequence type 328 strains in Russia, Belarus, and Kazakhstan
Q37383086Low-Concentration Ciprofloxacin Selects Plasmid-Mediated Quinolone Resistance Encoding Genes and Affects Bacterial Taxa in Soil Containing Manure
Q37810405Management of Complicated Urinary Tract Infections in the Era of Antimicrobial Resistance
Q93379617Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for the Rapid Detection of Antimicrobial Resistance Mechanisms and Beyond
Q58057075Mechanism of action of and resistance to quinolones
Q37701591Mechanism of quinolone action and resistance
Q42234726Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates
Q37437540Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs
Q36225422Mechanisms of drug resistance: quinolone resistance
Q37333074Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype.
Q27651667Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡
Q64065766Meta-transcriptomics reveals a diverse antibiotic resistance gene pool in avian microbiomes
Q42569707Metabolite proving fungal cleavage of the aromatic core part of a fluoroquinolone antibiotic
Q38046140Microbial transformations of antimicrobial quinolones and related drugs
Q33949396Modification of norfloxacin by a Microbacterium sp. strain isolated from a wastewater treatment plant
Q49854288Molecular Characteristics of First IMP-4-Producing Enterobacter cloacae Sequence Type 74 and 194 in Korea
Q38714815Molecular Identification of Aminoglycoside-Modifying Enzymes and Plasmid-Mediated Quinolone Resistance Genes among Klebsiella pneumoniae Clinical Isolates Recovered from Egyptian Patients.
Q37061620Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China
Q38863451Molecular characterization of antimicrobial resistance in Gram-negative bacteria isolated from bovine mastitis in Egypt.
Q28534905Molecular characterization of multidrug resistant hospital isolates using the antimicrobial resistance determinant microarray
Q34675362Molecular characterization of multidrug-resistant extended-spectrum β-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar
Q90398169Molecular epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonella in China, 2007-2016
Q37263634Molecular typing of CTX-M-producing escherichia coli isolates from environmental water, swine feces, specimens from healthy humans, and human patients.
Q61455372Molecules that Inhibit Bacterial Resistance Enzymes
Q22255652Multidrug resistance in bacteria
Q52649130Multidrug-Resistant Salmonella enterica 4,[5],12:i:- Sequence Type 34, New South Wales, Australia, 2016-2017.
Q58774429Multiple mechanisms contributing to ciprofloxacin resistance among Gram negative bacteria causing infections to cancer patients
Q37291349Multiresistant Enterobacteriaceae: new threat of an old problem
Q42747648Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.
Q38741903Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1.
Q39991540Nationwide survey of extended-spectrum {beta}-lactamase-producing Enterobacteriaceae in the French community setting
Q35484338New Delhi metallo-beta-lactamase from traveler returning to Canada
Q33422956New disturbing trend in antimicrobial resistance of gram-negative pathogens
Q36094929New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate
Q39230397Next-generation approaches to understand and combat the antibiotic resistome.
Q52629698Novel Ciprofloxacin-Modifying Enzyme (CrpP) Encoded by the Pseudomonas aeruginosa pUM505 Plasmid.
Q28534076Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates
Q34280271PMQR genes oqxAB and aac(6')Ib-cr accelerate the development of fluoroquinolone resistance in Salmonella typhimurium
Q90636536Palmatine Is a Plasmid-Mediated Quinolone Resistance (PMQR) Inhibitor That Restores the Activity of Ciprofloxacin Against QnrS and AAC(6')-Ib-cr-Producing Escherichia coli
Q41684776Performance of Etest and disk diffusion for detection of ciprofloxacin and levofloxacin resistance in Salmonella enterica
Q36439118Plasmid-Mediated OqxAB Is an Important Mechanism for Nitrofurantoin Resistance in Escherichia coli
Q48233168Plasmid-Mediated Quinolone Resistance (PMQR) Genes and Class 1 Integrons in Quinolone-Resistant Marine Bacteria and Clinical Isolates of Escherichia coli from an Aquacultural Area
Q40788996Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies
Q41337698Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates.
Q34888920Plasmid-mediated quinolone resistance
Q37215669Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015
Q36949478Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital
Q46388921Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake
Q30240591Plasmid-mediated quinolone resistance in Enterobacteriaceae: a systematic review with a focus on Mediterranean countries.
Q36932963Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France
Q38097417Plasmid-mediated quinolone resistance--current knowledge and future perspectives
Q24645356Plasmid-mediated quinolone resistance: a multifaceted threat
Q37970757Plasmid-mediated resistance in Enterobacteriaceae: changing landscape and implications for therapy
Q42218073Plasmid-related quinolone resistance determinants in epidemic Vibrio parahaemolyticus, uropathogenic Escherichia coli, and marine bacteria from an aquaculture area in Chile
Q40368674Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions.
Q34019104Plasmidic qnrA3 enhances Escherichia coli fitness in absence of antibiotic exposure
Q53694871Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia.
Q50063564Polymorphism of antibiotic-inactivating enzyme driven by ecology expands the environmental resistome.
Q91899108Population-based inference of aminoglycoside resistance mechanisms in Escherichia coli
Q42773186Practical disk-based method for detection of Escherichia coli clinical isolates producing the fluoroquinolone-modifying enzyme AAC(6')-Ib-cr
Q37002813Predicting antibiotic resistance
Q47269627Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes.
Q33369591Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants
Q37562416Predictors and molecular epidemiology of community-onset extended-spectrum β-lactamase-producing Escherichia coli infection in a Midwestern community
Q42155904Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro River located in the State of Aguascalientes, Mexico
Q47123962Prevalence and characteristics of ST131 clone among unselected clinical Escherichia coli in a Chinese university hospital
Q44386898Prevalence and characteristics of quinolone resistance in Escherichia coli in veal calves
Q50016432Prevalence and characterization of plasmid-mediated quinolone resistance genes in Salmonella isolated from poultry in Korea
Q34151135Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment.
Q36295421Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1
Q40903405Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital
Q35127937Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
Q50045041Prevalence of Antimicrobial Resistance Among Salmonella Isolates from Chicken in China
Q39030066Prevalence of Plasmid-Mediated Quinolone Resistance Determinants and OqxAB Efflux Pumps among Extended-Spectrum β-Lactamase Producing Klebsiella pneumoniae Isolated from Patients with Nosocomial Urinary Tract Infection in Tehran, Iran.
Q36560276Prevalence of Quinolone Resistance Genes Among Extended-Spectrum B-Lactamase-Producing Escherichia coli in Mashhad, Iran
Q40559404Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites
Q42111676Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea
Q38269819Prevalence of aac(6')-Ib-cr plasmid-mediated and chromosome-encoded fluoroquinolone resistance in Enterobacteriaceae in Italy
Q34460490Prevalence of plasmid-mediated quinolone resistance and aminoglycoside resistance determinants among carbapeneme non-susceptible Enterobacter cloacae
Q45769596Prevalence of plasmid-mediated quinolone resistance determinants in Enterobacteriaceae strains isolated in North-East Italy
Q37072043Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period
Q34238560Prevalence of plasmid-mediated quinolone resistance genes among ciprofloxacin-nonsusceptible Escherichia coli and Klebsiella pneumoniae isolated from blood cultures in Korea
Q43142462Prevalence of plasmid-mediated quinolone-resistance determinants in Shigella flexneri isolates from Anhui Province, China
Q36234519Prevalence of qnr and aac(6')-Ib-cr Genes in Clinical Isolates of Klebsiella Pneumoniae from Imam Hussein Hospital in Tehran
Q41910731Prevalence of qnr, aac(6')-Ib-cr, qepA, and oqxAB in Escherichia coli isolates from humans, animals, and the environment
Q46021276Prevalence of qnrA, qnrB, qnrS and aac(6')-Ib-cr (in qnr-positive isolates) among ESBL-positive and/or ciprofloxacin-resistant isolates in Turkey.
Q38117380Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance
Q53720579Quantitative and automated MALDI-TOF MS-based detection of the plasmid-mediated quinolone resistance determinant AAC(6')-Ib-cr in Enterobacteriaceae.
Q64120325Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains
Q41454301Quantitative contributions of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance
Q35155107Quinolone resistance mechanisms among extended-spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from rivers and lakes in Switzerland.
Q39737709Quinolone resistance: much more than predicted.
Q40137027Quinolone-resistant Escherichia coli isolated from birds of prey in Portugal are genetically distinct from those isolated from water environments and gulls in Portugal, Spain and Sweden
Q37595559Quinolones: action and resistance updated
Q34133116Quinolones: from antibiotics to autoinducers
Q34090820RAC: Repository of Antibiotic resistance Cassettes
Q48721120Rapid Detection of Bacterial Susceptibility or Resistance to Quinolones
Q41835144Rapid and simple determination of ciprofloxacin resistance in clinical strains of Escherichia coli
Q33429716Rapid assessment of the effect of ciprofloxacin on chromosomal DNA from Escherichia coli using an in situ DNA fragmentation assay
Q36112167Rapid detection of AAC(6')-Ib-cr production using a MALDI-TOF MS strategy
Q41865434Rapid detection of aac(6')-Ib-cr quinolone resistance gene by pyrosequencing.
Q50963299Rapid detection of the plasmid-mediated quinolone resistance determinant AAC(6')-Ib-cr in Enterobacteriaceae by MALDI-TOF MS analysis.
Q40505708Rapid determination of β-lactam antimicrobial resistance in bacteria by a liquid chromatography-mass spectrometry-based method
Q42112155Rapid dissemination and diversity of CTX-M extended-spectrum beta-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America.
Q37273373Reducing Vibrio load in Artemia nauplii using antimicrobial photodynamic therapy: a promising strategy to reduce antibiotic application in shrimp larviculture
Q41975822Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates
Q38233471Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones
Q47145339Report from the Task Force on Zoonoses Data Collection including guidance for harmonized monitoring and reporting of antimicrobial resistance in commensal Escherichia coli and Enterococcus spp. from food animals
Q47144684Report of the Task Force on Zoonoses Data Collection including a proposal for a harmonized monitoring scheme of antimicrobial resistance in Salmonella in fowl (Gallus gallus), turkeys and pigs and Campylobacter jejuni and C. coli in broilers
Q37577369Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
Q58790125Revisiting Polymorphic Diversity of Aminoglycoside -Acetyltransferase AAC(6')-Ib Based on Bacterial Genomes of Human, Animal, and Environmental Origins
Q36850490Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm
Q37286916Risk factors and clinical characteristics of patients with qnr-positive Klebsiella pneumoniae bacteraemia
Q26774868SOS response and its regulation on the fluoroquinolone resistance
Q34384553Salmon aquaculture and antimicrobial resistance in the marine environment
Q43218774Serogroup A Neisseria meningitidis with reduced susceptibility to ciprofloxacin
Q30424691Serratia infections: from military experiments to current practice
Q89565775Shigella flexneri: an emerging pathogen
Q26739692Shigellosis: Epidemiology in India
Q35840807Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal
Q34483705Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor
Q28533900Structural diversity of class 1 integrons and their associated gene cassettes in Klebsiella pneumoniae isolates from a hospital in China
Q27666560Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium
Q35139484Susceptibility of vertilmicin to modifications by three types of recombinant aminoglycoside-modifying enzymes
Q36954344Synonymous genes explore different evolutionary landscapes.
Q42065966Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets
Q37144821Temporal appearance of plasmid-mediated quinolone resistance genes
Q30393373The Genomic Enzymology of Antibiotic Resistance
Q37304655The SOS response promotes qnrB quinolone-resistance determinant expression
Q29544028The antibiotic resistome: the nexus of chemical and genetic diversity
Q43168377The characteristics of VIM-1-producing Klebsiella pneumoniae from South Africa
Q28533846The culturable soil antibiotic resistome: a community of multi-drug resistant bacteria
Q49306295The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
Q54331161The first report of the qnrB19, qnrS1 and aac(6´)-Ib-cr genes in urinary isolates of ciprofloxacin-resistant Escherichia coli in Brazil.
Q37110496The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex
Q34922676The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility
Q93264979The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis
Q43127420The role of class 1 and 2 integrons in mediating antimicrobial resistance among canine and feline clinical E. coli isolates from the US.
Q34569740The worldwide emergence of plasmid-mediated quinolone resistance
Q38906198Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance
Q35879095Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli
Q31168336Transformation of N-phenylpiperazine by mixed cultures from a municipal wastewater treatment plant
Q35023629Transformation of the antibacterial agent norfloxacin by environmental mycobacteria
Q37713699Travel-related carbapenemase-producing Gram-negative bacteria in Alberta, Canada: the first 3 years
Q37067902Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement
Q34922895Trends in serotype distribution and antimicrobial susceptibility in Salmonella enterica isolates from humans in Belgium, 2009 to 2013.
Q33726354Unique Features of Aeromonas Plasmid pAC3 and Expression of the Plasmid-Mediated Quinolone Resistance Genes
Q47555917Uropathogenic Escherichia coli in the Urine Samples of Iranian Dogs: Antimicrobial Resistance Pattern and Distribution of Antibiotic Resistance Genes.
Q48306999Use of a Commercially Available Microarray to Characterize Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae
Q40406138Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
Q55215658Wicked: The untold story of ciprofloxacin.
Q40006196Zoo animals as reservoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes
Q42146558aac(6')-Ib-cr genotyping by simultaneous high-resolution melting analyses of an unlabeled probe and full-length amplicon
Q36738342beta-Lactam resistance and beta-lactamases in bacteria of animal origin
Q37144817blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures
Q48053181qnr, aac(6')-Ib-cr and qepA genes in Escherichia coli and Klebsiella spp.: genetic environments and plasmid and chromosomal location
Q46613232qnrA6 genetic environment and quinolone resistance conferred on Proteus mirabilis