The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex

scientific article published on 05 December 2008

The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JB.01205-08
P932PMC publication ID2648189
P698PubMed publication ID19060136

P2093author name stringVincent Jarlier
Emmanuelle Cambau
Alexandra Aubry
Stéphanie Matrat
Audrey Mérens
Jean-Didier Cavallo
Christine Lascols
Claude-James Soussy
P2860cites workInteraction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87).Q39477717
Functional characterisation of mycobacterial DNA gyrase: an efficient decatenaseQ39607881
Mycobacterial cell wall: structure and role in natural resistance to antibioticsQ40648841
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.Q41008865
Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolonesQ41825585
Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinantsQ42618006
Vibrio parahaemolyticus chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in Escherichia coliQ42727492
The Glu-84 of the ParC subunit plays critical roles in both topoisomerase IV-quinolone and topoisomerase IV-DNA interactionsQ44148098
Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyraseQ46377091
An atypical type II topoisomerase from Mycobacterium smegmatis with positive supercoiling activityQ46824415
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferaseQ46862305
Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella entericaQ50079326
First functional characterization of a singly expressed bacterial type II topoisomerase: the enzyme from Mycobacterium tuberculosis.Q53608367
Quinolone resistance from a transferable plasmid.Q54143628
Analysis of the NH2-terminal 87th amino acid of Escherichia coli GyrA in quinolone-resistance.Q54619902
Occurrence of qnrA-positive clinical isolates in French teaching hospitals during 2002–2005Q61248547
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceQ22122411
Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142Q24648111
Pentapeptide repeat proteinsQ24653739
Structure and distribution of pentapeptide repeats in bacteriaQ24673061
Crystal structure of the breakage-reunion domain of DNA gyraseQ27742546
Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activityQ28486793
American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of AmericaQ29391534
Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpAQ32035273
The action of the bacterial toxin, microcin B17, on DNA gyraseQ33271871
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyraseQ33556397
Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IVQ33883611
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.Q33987554
Mechanism of plasmid-mediated quinolone resistanceQ34025874
The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone actionQ34092838
Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolonesQ34352135
Emergence of plasmid-mediated resistance to quinolones in EnterobacteriaceaeQ34434110
qnrB, another plasmid-mediated gene for quinolone resistanceQ34510366
The worldwide emergence of plasmid-mediated quinolone resistanceQ34569740
Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, ChinaQ35102456
Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzymeQ35127937
Fluoroquinolones, tuberculosis, and resistanceQ35167433
Use of in vitro topoisomerase II assays for studying quinolone antibacterial agentsQ35354154
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerasesQ35771555
Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coliQ35879095
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolateQ36094929
Efflux-mediated antimicrobial resistanceQ36138147
Mechanisms of resistance to quinolonesQ36155441
Protein mimicry of DNA and pathway regulationQ36287050
qnr Gene nomenclatureQ36744808
Mutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolonesQ36804000
The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA).Q39117573
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectquinolonesQ426549
P304page(s)1587-1594
P577publication date2008-12-05
P1433published inJournal of BacteriologyQ478419
P1476titleThe pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex
P478volume191

Reverse relations

cites work (P2860)
Q36684174Comparative analysis of an IncR plasmid carrying armA, blaDHA-1 and qnrB4 from Klebsiella pneumoniae ST37 isolates.
Q39210590DNA Replication in Mycobacterium tuberculosis
Q40623215High prevalence of plasmid-mediated quinolone resistance determinants in Enterobacter cloacae isolated from hospitals of the Qazvin, Alborz, and Tehran provinces, Iran.
Q35960942Interactions between QnrB, QnrB mutants, and DNA gyrase
Q55445576Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice.
Q42201141Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli.
Q64058655Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function
Q36225422Mechanisms of drug resistance: quinolone resistance
Q91762059Mobilome and Resistome Reconstruction from Genomes Belonging to Members of the Bifidobacterium Genus
Q36619820Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance
Q36757607Phylogenetic analysis of chromosomally determined qnr and related proteins
Q34888920Plasmid-mediated quinolone resistance
Q24645356Plasmid-mediated quinolone resistance: a multifaceted threat
Q34019104Plasmidic qnrA3 enhances Escherichia coli fitness in absence of antibiotic exposure
Q36158288Protective effect of Qnr on agents other than quinolones that target DNA gyrase
Q34339689Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development.
Q33909989QnrS1 structure-activity relationships
Q38262589Squaring up to DNA: pentapeptide repeat proteins and DNA mimicry
Q34483705Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor
Q27666560Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium
Q27667906Structure of QnrB1, a Plasmid-mediated Fluoroquinolone Resistance Factor
Q92633491The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents
Q92154411The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress
Q52646354Trends in the discovery of new drugs for Mycobacterium tuberculosis therapy with a glance at resistance.
Q46613232qnrA6 genetic environment and quinolone resistance conferred on Proteus mirabilis

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