Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia.

scientific article published on 16 April 2018

Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00202-18
P932PMC publication ID6021647
P698PubMed publication ID29661878

P50authorShane J CaldwellQ56748090
Albert M BerghuisQ56748093
P2093author name stringShane J Caldwell
P2860cites workMechanisms of gentamicin resistance in Staphylococcus aureusQ24600870
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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscodingQ24817111
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Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substratesQ27639456
Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡Q27651667
Chemical and Structural Insights into the Regioversatility of the Aminoglycoside Acetyltransferase EisQ27680200
Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-IaQ27704833
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Protein production by auto-induction in high density shaking culturesQ27860514
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Aminoglycoside antibiotic phosphotransferases are also serine protein kinasesQ30432470
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Mutant APH(2'')-IIa enzymes with increased activity against amikacin and isepamicinQ33768781
Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysisQ34299292
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Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacinQ36461620
2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmidQ36464447
Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzymeQ36481710
Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) groupQ38311956
Mutations in the aph(2")-Ic gene are responsible for increased levels of aminoglycoside resistanceQ39658050
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Expanding Aminoglycoside Resistance Enzyme Regiospecificity by Mutation and TruncationQ40543501
Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococciQ40824066
Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structureQ41885933
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Molecular mechanism for the enhancement of arbekacin resistance in a methicillin-resistant Staphylococcus aureusQ44495062
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Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferaseQ46862305
Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complexQ46965268
A spontaneous point mutation in the aac(6')-Ib' gene results in altered substrate specificity of aminoglycoside 6'-N-acetyltransferase of a Pseudomonas fluorescens strainQ48085740
Kanamycin and its derivative, arbekacin: significance and impactQ50197980
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Enzymatic 1-N-acetylation of paromomycin by an actinomycete strain #8 with multiple aminoglycoside resistance and paromomycin sensitivity.Q54058358
Structures of enzymatically modified products of arbekacin by methicillin-resistant. Staphylococcus aureus.Q54247959
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NMR and amber analysis of the neamine pharmacophore for the design of novel aminoglycoside antibioticsQ82654620
P433issue7
P407language of work or nameEnglishQ1860
P577publication date2018-06-26
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePlasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia
P478volume62

Reverse relations

Q97424799A kinase bioscavenger provides antibiotic resistance by extremely tight substrate bindingcites workP2860

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