Quantitative contributions of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance (scientific article published on 28 December 2012)

A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants

Q29547327

High throughput automated allele frequency estimation by pyrosequencing

Q33352030

Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility

Q33372694

Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa

Q33424246

Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa.

Q33975861

Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli.

Q33976675

Carbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates

Q33981394

Type II topoisomerase mutations in fluoroquinolone-resistant clinical strains of Pseudomonas aeruginosa isolated in 1998 and 1999: role of target enzyme in mechanism of fluoroquinolone resistance

Q33982709

Mechanism of plasmid-mediated quinolone resistance

Q34025874

The worldwide emergence of plasmid-mediated quinolone resistance

Q34569740

Fluoroquinolone antimicrobial agents

Q34613302

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

Q34750112

Overexpression of AmpC and efflux pumps in Pseudomonas aeruginosa isolates from bloodstream infections: prevalence and impact on resistance in a Spanish multicenter study

Q34932869

Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection.

Q35107937

Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem

Q35119495

The mutant selection window and antimicrobial resistance

Q35153856

Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitro

Q35821472

Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli

Q35879095

Efflux-mediated antimicrobial resistance

Q36138147

Nosocomial infections due to multidrug-resistant Pseudomonas aeruginosa: epidemiology and treatment options

Q36268383

Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation

Q36295397

Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa

Q37348842

Review of studies of the impact on Gram-negative bacterial resistance on outcomes in the intensive care unit

Q37401036

Quinolones: action and resistance updated

Q37595559

Parallel evolution and local differentiation in quinolone resistance in Pseudomonas aeruginosa

Q37835568

Antagonistic interactions of Pseudomonas aeruginosa antibiotic resistance mechanisms in planktonic but not biofilm growth.

Q38626934

Bacterial resistance to the quinolone antimicrobial agents

Q38746710

Detection of gyrA mutations among 335 Pseudomonas aeruginosa strains isolated in Japan and their susceptibilities to fluoroquinolones

Q39469894

Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa

Q39470847

Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients

Q39473195

Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87).

Q39477717

Quinolone-resistant Haemophilus influenzae: determination of mutant selection window for ciprofloxacin, garenoxacin, levofloxacin, and moxifloxacin

Q39698735

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.

Q39785139

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

Q39816339

Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa

Q39816347

Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

Q40334912

Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli

Q41788804

The relative contribution of efflux and target gene mutations to fluoroquinolone resistance in recent clinical isolates of Pseudomonas aeruginosa

Q43184919

Comparative pharmacokinetics of ciprofloxacin and ofloxacin in cystic fibrosis patients

Q44067245

Fluoroquinolone-resistant Pseudomonas aeruginosa: assessment of risk factors and clinical impact

Q44132698

Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa

Q44426754

Role of efflux pumps and mutations in genes for topoisomerases II and IV in fluoroquinolone-resistant Pseudomonas aeruginosa strains

Q44786412

Contribution of ParE mutation and efflux to ciprofloxacin resistance in Pseudomonas aeruginosa clinical isolates

Q46172031

Alterations in the GyrA and GyrB subunits of topoisomerase II and the ParC and ParE subunits of topoisomerase IV in ciprofloxacin-resistant clinical isolates of Pseudomonas aeruginosa

Q46397999

Carbapenem resistance mechanisms in Pseudomonas aeruginosa: alterations of porin OprD and efflux proteins do not fully explain resistance patterns observed in clinical isolates

Q46412289

Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

Q46862305

Small, stable shuttle vectors based on the minimal pVS1 replicon for use in gram-negative, plant-associated bacteria.

Q47887383

Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.

Q54105307

Contributions of efflux pumps to high level resistance of Pseudomonas aeruginosa to ciprofloxacin

Q79664046

Pyrosequencing protocol using a universal biotinylated primer for mutation detection and SNP genotyping

Q80643394

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

Pseudomonas aeruginosa

Q31856

P304

page(s)

1361-1368

P577

publication date

2012-12-28

P1433

published in

Antimicrobial Agents and Chemotherapy

Q578004

P1476

title

Quantitative contributions of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance

P478

volume

Reverse relations

cites work (P2860)

Q64914064	Amsacrine Derivatives Selectively Inhibit Mycobacterial Topoisomerase I (TopA), Impair M. smegmatis Growth and Disturb Chromosome Replication.
Q59126430	Association between possession of ExoU and antibiotic resistance in Pseudomonas aeruginosa
Q57060635	BACTOME-a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates
Q40108765	Biofilm formation and antibiotic susceptibility in dispersed cells versus planktonic cells from clinical, industry and environmental origins.
Q98215924	Development of in vitro resistance to fluoroquinolones in Pseudomonas aeruginosa
Q98245614	Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
Q34992258	Efflux-mediated fluoroquinolone resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7: identification of a novel MexS variant involved in upregulation of the mexEF-oprN multidrug efflux operon
Q37712123	Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland
Q41066625	Evolution of Cost-Free Resistance under Fluctuating Drug Selection in Pseudomonas aeruginosa
Q40056971	Genomics and Susceptibility Profiles of Extensively Drug-Resistant (XDR) Pseudomonas aeruginosa from Spain.
Q36262179	High-throughput automated microfluidic sample preparation for accurate microbial genomics.
Q38856197	Host and Pathogen Biomarkers for Severe Pseudomonas aeruginosa Infections
Q38977280	In Vitro Antibiofilm Efficacies of Different Antibiotic Combinations with Zinc Sulfate against Pseudomonas aeruginosa Recovered from Hospitalized Patients with Urinary Tract Infection
Q41060499	In vivo evolution of resistance of Pseudomonas aeruginosa strains isolated from patients admitted to an intensive care unit: mechanisms of resistance and antimicrobial exposure.
Q90472440	Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center
Q64100644	MexXY Multidrug Efflux System Is More Frequently Overexpressed in Ciprofloxacin Resistant French Clinical Isolates Compared to Hospital Environment Ones
Q40559371	Molecular Epidemiology of Mutations in Antimicrobial Resistance Loci of Pseudomonas aeruginosa Isolates from Airways of Cystic Fibrosis Patients
Q64238157	Mutations in play an important role in ciprofloxacin-resistant
Q61449168	Persistence and Microevolution of in the Cystic Fibrosis Lung: A Single-Patient Longitudinal Genomic Study
Q89671585	Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics
Q92429989	Regulatory Mechanisms of the LuxS/AI-2 System and Bacterial Resistance
Q41687386	Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor
Q52313185	The Versatile Mutational Resistome of Pseudomonas aeruginosa.
Q35482558	The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria
Q42659717	The genetic basis of the fitness costs of antimicrobial resistance: a meta-analysis approach
Q34922676	The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility
Q37120056	Transcriptome Profiling of Antimicrobial Resistance in Pseudomonas aeruginosa
Q61444724	Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa
Q35062974	Whole genome and transcriptome analyses of environmental antibiotic sensitive and multi-resistant Pseudomonas aeruginosa isolates exposed to waste water and tap water.
Q62899027	Whole genome sequencing reveals the emergence of a Pseudomonas aeruginosa shared strain sub-lineage among patients treated within a single cystic fibrosis centre
Q36300937	Within-host whole genome analysis of an antibiotic resistant Pseudomonas aeruginosa strain sub-type in cystic fibrosis