Abstract is: RAC otherwise known as Repository of Antibiotic resistance Cassettes is a database that uses the automatic Attacca annotation system in order to comprehensively annotate gene-cassettes and transposable elements in a stream-lined manner and to discover novel gene cassettes. Antibiotic resistance is often due to horizontal gene transfer, which allows resistance to arise through cell-to-cell interaction. This poses a major challenge in the field of antibiotic resistance. Hence, the creation of RAC which would provide researchers a comprehensive and unique tool for the endeavor of documenting resistance due to gene-cassettes and transposable elements. Attacca helps discover novel gene cassettes when any three of the following occurs as mentioned in Tsafnat et al, 2011: * the Attacca discovery heuristics (19) identify a gap in a cassette array that could correspond to a novel cassette; * a cassette encoding a potentially novel β-lactamase variant is detected; or * the type of sequence submitted (e.g. isolated cassette) suggests that a gene cassette should be present but a gene cassette is not found by Attacca. If any of these cases occur, the gene-cassette would be sent to review at the Centre for Infectious Diseases and Microbiology, University of Sydney for further examination.
| scholarly article | Q13442814 |
| P356 | DOI | 10.1093/DATABASE/BAR054 |
| P2671 | Google Knowledge Graph ID | /g/11g9m5qj7f |
| P932 | PMC publication ID | 3229207 |
| P698 | PubMed publication ID | 22140215 |
| P5875 | ResearchGate publication ID | 51852342 |
| P50 | author | Guy Tsafnat | Q57699885 |
| P2093 | author name string | Sally R Partridge | |
| Joseph Copty | |||
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| P304 | page(s) | bar054 | |
| P577 | publication date | 2011-12-02 | |
| P1433 | published in | Database | Q5227381 |
| P1476 | title | RAC: Repository of Antibiotic resistance Cassettes | |
| P478 | volume | 2011 |
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