| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Shane J Caldwell | Q56748090 |
| Albert M Berghuis | Q56748093 | ||
| P2093 | author name string | Kun Shi | |
| Desiree H Fong | |||
| P2860 | cites work | Structural evolution of the protein kinase-like superfamily | Q21145694 |
| Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action | Q21195823 | ||
| Combating antimicrobial resistance: policy recommendations to save lives | Q24632857 | ||
| Three decades of beta-lactamase inhibitors | Q24646623 | ||
| Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli | Q24677112 | ||
| Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics | Q27627265 | ||
| Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase | Q27633415 | ||
| Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry | Q27638972 | ||
| The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance | Q27640684 | ||
| Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity | Q27647572 | ||
| The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2''-Phosphotransferase-IIa [APH(2'')-IIa] Provide Insights into Substrate Selectivity in the APH(2'') Subfamily | Q27655435 | ||
| Structural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics | Q27655445 | ||
| Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila | Q27659071 | ||
| Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2″-IVa | Q27662400 | ||
| Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme | Q27665944 | ||
| Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor | Q27667856 | ||
| Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases | Q27670461 | ||
| Crystal structure of Mycobacterium tuberculosis Rv3168: a putative aminoglycoside antibiotics resistance enzyme | Q27673650 | ||
| Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues | Q27673672 | ||
| A small molecule discrimination map of the antibiotic resistance kinome | Q27676394 | ||
| Aminoglycoside 2′′-Phosphotransferase IIIa (APH(2′′)-IIIa) Prefers GTP over ATP | Q27677499 | ||
| Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases | Q27677520 | ||
| Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia | Q41841439 | ||
| Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure | Q41885933 | ||
| Strategies to control community-associated antimicrobial resistance among enteric bacteria and methicillin-resistant Staphylococcus aureus in Canada - executive summary | Q42412532 | ||
| The nucleotide sequence of a streptomycin streptomycin phosphotransferase (streptomycin kinase) [corrected] gene from a streptomycin producer | Q42647975 | ||
| A spectinomycin resistance determinant from the spectinomycin producer Streptomyces flavopersicus | Q42661395 | ||
| Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria | Q42849742 | ||
| Sequence and interspecies transfer of an aminoglycoside phosphotransferase gene (APH) of Bacillus circulans. Self-defence mechanism in antibiotic-producing organisms | Q42867420 | ||
| Aminoglycosides: a practical review | Q43458641 | ||
| Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5 | Q43810140 | ||
| The syntheses and biological properties of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B. | Q44236334 | ||
| Influence of population density on antibiotic resistance | Q44299896 | ||
| The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity. | Q45104403 | ||
| Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus. | Q46804930 | ||
| Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase | Q46862305 | ||
| Isolation and characterisation of an aminoglycoside phosphotransferase from neomycin-producing Micromonospora chalcea; comparison with that of Streptomyces fradiae and other producers of 4,6-disubstituted 2-deoxystreptamine antibiotics. | Q48199304 | ||
| Nucleotide sequence of the ribostamycin phosphotransferase gene and of its control region in Streptomyces ribosidificus | Q48315832 | ||
| Nucleotide sequence of Acinetobacter baumannii aphA-6 gene: evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes | Q48316625 | ||
| Nucleotide sequence of the kanamycin resistance determinant of plasmid RP4: homology to other aminoglycoside 3'-phosphotransferases | Q48336227 | ||
| Gene cluster for streptomycin biosynthesis in Streptomyces griseus: analysis of a central region including the major resistance gene | Q48343779 | ||
| Characterisation of the hydroxystreptomycin phosphotransferase gene (sph) of Streptomyces glaucescens: nucleotide sequence and promoter analysis | Q48343789 | ||
| The sequence of an antibiotic resistance gene from an antibiotic-producing bacterium. Homologies with transposon genes | Q48396816 | ||
| Nucleotide sequence of the kanamycin resistance transposon Tn903 | Q48410053 | ||
| Assessment of 6'- and 6'''-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance. | Q50525805 | ||
| Bacteriophages as anti-infective agents: recent developments and regulatory challenges. | Q50936427 | ||
| Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. | Q52021317 | ||
| BB-K 8, a new semisynthetic aminoglycoside antibiotic | Q53854812 | ||
| Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications. | Q53981567 | ||
| 3',4'-dideoxy-kanamycin B active against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa | Q54668246 | ||
| Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome. | Q55033593 | ||
| Phosphotransferase sequence homology | Q59097531 | ||
| The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance | Q59647662 | ||
| Letter: Syntheses of 1-n-(S)-4-amino-2-hydroxybutyryl)-kanamycin B and -3', 4'-dideoxykanamycin B active against kanamycin-resistant bacteria | Q69662851 | ||
| A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3"-phosphotransferase. Relationships between antibiotic and protein kinases | Q69837970 | ||
| Structural relationship between the genes encoding 3'-aminoglycoside phosphotransferases in Campylobacter and in gram-positive cocci | Q70121209 | ||
| Enzymatic 2'-N-acetylation of arbekacin and antibiotic activity of its product | Q71195666 | ||
| Structure of nebramycin factor 6, a new aminoglycosidic antibiotic | Q71706529 | ||
| Dissociation rate of cognate peptidyl-tRNA from the A-site of hyper-accurate and error-prone ribosomes | Q71989225 | ||
| Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib | Q80138477 | ||
| Aminoglycosides--50 years on | Q95806228 | ||
| Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin | Q27681169 | ||
| Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification | Q28131753 | ||
| Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop | Q28201037 | ||
| Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases | Q28242098 | ||
| Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity | Q28254805 | ||
| Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae | Q28265770 | ||
| Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases | Q28285315 | ||
| Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism | Q28286741 | ||
| Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. | Q28379520 | ||
| The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents | Q28482276 | ||
| Interaction of antibiotics with functional sites in 16S ribosomal RNA | Q29616813 | ||
| Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies | Q29617810 | ||
| Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin | Q30701387 | ||
| Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes | Q33222759 | ||
| Novel streptomycin resistance gene from Mycobacterium fortuitum | Q33256453 | ||
| A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp. | Q33695820 | ||
| Conformational diversity of catalytic cores of protein kinases | Q33716092 | ||
| Challenges of antibacterial discovery | Q33793074 | ||
| Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium | Q33980844 | ||
| Antibiotics in agriculture: when is it time to close the barn door? | Q34026413 | ||
| New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. | Q34139570 | ||
| Vaccines and antibiotic resistance | Q34299849 | ||
| Potential novel therapeutic strategies in cystic fibrosis: antimicrobial and anti-biofilm activity of natural and designed α-helical peptides against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. | Q34348146 | ||
| Aminoglycoside modifying enzymes | Q34354185 | ||
| Role of aminoglycosides in the treatment of bacterial endocarditis | Q34543623 | ||
| Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects | Q34632230 | ||
| 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides | Q34635355 | ||
| Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK. | Q34666418 | ||
| Evolution of drug-resistant tuberculosis: a tale of two species | Q34727650 | ||
| Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia | Q34999856 | ||
| Pseudomonas aeruginosa: resistance to the max | Q35084559 | ||
| A novel gentamicin resistance gene in Enterococcus | Q35133224 | ||
| Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila | Q35136872 | ||
| Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation | Q35165835 | ||
| Versatility of aminoglycosides and prospects for their future | Q35176271 | ||
| Dissemination of amikacin resistance gene aphA6 in Acinetobacter spp. | Q35263167 | ||
| Transferable amikacin resistance in Acinetobacter spp. due to a new type of 3'-aminoglycoside phosphotransferase | Q35287840 | ||
| Treatment of gonorrhea with spectinomycin hydrochloride: comparison with standard penicillin schedules | Q35639303 | ||
| Efflux-mediated antimicrobial resistance | Q36138147 | ||
| Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activiti | Q36249835 | ||
| Localization of an Amikacin 3′-Phosphotransferase in Escherichia coli | Q36307365 | ||
| Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups | Q36396224 | ||
| Transient kinetics of aminoglycoside phosphotransferase(3')-IIIa reveals a potential drug target in the antibiotic resistance mechanism | Q36434917 | ||
| MexXY multidrug efflux system of Pseudomonas aeruginosa | Q36450695 | ||
| Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme | Q36481710 | ||
| Pharmacokinetic justification of antiprotozoal therapy. A US perspective | Q36935048 | ||
| Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. | Q37058913 | ||
| Bacterial uptake of aminoglycoside antibiotics. | Q37063992 | ||
| Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases encoded by resistance plasmids | Q37346955 | ||
| Through the "gatekeeper door": exploiting the active kinase conformation | Q37650047 | ||
| The future of aminoglycosides: the end or renaissance? | Q37732085 | ||
| Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis | Q37783433 | ||
| Aminoglycoside use in cystic fibrosis: therapeutic strategies and toxicity. | Q37784975 | ||
| Combating evolution with intelligent design: the neoglycoside ACHN-490 | Q37798897 | ||
| Antibiotic adjuvants: multicomponent anti-infective strategies. | Q37845955 | ||
| Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update | Q38016662 | ||
| Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group | Q38311956 | ||
| Aminoglycoside 3'-phosphotransferases I and II in Pseudomonas aeruginosa | Q39337456 | ||
| Evolution and transfer of aminoglycoside resistance genes under natural conditions | Q39506885 | ||
| Detection of two different kanamycin resistance genes in naturally occurring isolates of Campylobacter jejuni and Campylobacter coli | Q39818637 | ||
| The chemistry of synthetic and semisynthetic penicillins | Q39999947 | ||
| Mechanism of Aminoglycoside Antibiotic Resistance in Anaerobic Bacteria: Clostridium perfringens and Bacteroides fragilis | Q40214702 | ||
| Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance | Q40284952 | ||
| Nucleotide selectivity of antibiotic kinases | Q40337157 | ||
| Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa | Q40543666 | ||
| Nucleotide sequence of the hygromycin B phosphotransferase gene from Streptomyces hygroscopicus | Q40560165 | ||
| Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci | Q40824066 | ||
| Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors | Q40881651 | ||
| Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae | Q41131892 | ||
| Ribosomal RNA and protein mutants resistant to spectinomycin | Q41204307 | ||
| Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases. | Q41776282 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | antibiotic resistance | Q380775 |
| enzyme inhibitor | Q427492 | ||
| enzyme | Q8047 | ||
| mechanism of action | Q3271540 | ||
| carbohydrate | Q11358 | ||
| antibiotic | Q12187 | ||
| bacterial drug resistance | Q64924127 | ||
| P304 | page(s) | 22 | |
| P577 | publication date | 2013-06-25 | |
| P1433 | published in | Frontiers in Cellular and Infection Microbiology | Q27724376 |
| P1476 | title | Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance | |
| P478 | volume | 3 |
| Q36726249 | A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides |
| Q92260143 | Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum |
| Q83230926 | Combinations of genes create multiple meiotic drivers in |
| Q48317932 | Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities |
| Q92756013 | Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT |
| Q64100632 | ICESsuHN105, a Novel Multiple Antibiotic Resistant ICE in Streptococcus suis Serotype 5 Strain HN105 |
| Q35887323 | Identification and classification of small molecule kinases: insights into substrate recognition and specificity. |
| Q53777899 | Identification of Genes Coding Aminoglycoside Modifying Enzymes in E. coli of UTI Patients in India. |
| Q35960810 | Inhibition of AAC(6')-Ib-mediated resistance to amikacin in Acinetobacter baumannii by an antisense peptide-conjugated 2',4'-bridged nucleic acid-NC-DNA hybrid oligomer |
| Q58735304 | Look and Outlook on Enzyme-Mediated Macrolide Resistance |
| Q36575916 | Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives |
| Q35053439 | Mechanisms of antibiotic resistance |
| Q64068087 | Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Producing ST131 Escherichia coli |
| Q61806023 | Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles |
| Q36933502 | Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System |
| Q38819114 | Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin |
| Q27684260 | Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia |
| Q39392178 | Use of bacterial whole-genome sequencing to understand and improve the management of invasive Staphylococcus aureus infections |
| Q40225203 | Utilizing Paper-Based Devices for Antimicrobial-Resistant Bacteria Detection |
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