Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.

scientific article published on 26 October 2009

Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00972-09
P932PMC publication ID2798491
P698PubMed publication ID19858260
P5875ResearchGate publication ID38037590

P50authorAnthony MaxwellQ37380949
Manlio PalumboQ39519418
P2093author name stringL A Mitchenall
E Vazquez
C Sissi
A Chemello
P2860cites workStructural insight into the quinolone-DNA cleavage complex of type IIA topoisomerasesQ27655501
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyraseQ27658456
DNA gyrase as a drug targetQ28139769
The ATP-binding site of type II topoisomerases as a target for antibacterial drugsQ28207771
The interaction between coumarin drugs and DNA gyraseQ28256018
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040.Q31096529
DNA gyrase: an enzyme that introduces superhelical turns into DNAQ34013173
The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone actionQ34092838
The fluoroquinolone antibacterials: past, present and future perspectivesQ34143393
DNA gyrase: structure and function.Q34507230
Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzymeQ35059616
Energy coupling in DNA gyrase and the mechanism of action of novobiocinQ35994466
Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II.Q36136076
Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism.Q36775907
Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agentsQ36907300
Quinolone-mediated bacterial death.Q36921143
Antimicrobial resistance in hospitals: how concerned should we be?Q37088893
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticusQ37190713
DNA topoisomerases: harnessing and constraining energy to govern chromosome topologyQ37255381
Therapeutic challenges in the era of antibiotic resistanceQ37365771
What's new on the antimicrobial horizon?Q37365775
DNA Gyrase and DNA SupercoilingQ40251916
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallographyQ41064279
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of actionQ41093787
Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ionsQ43685586
Sites of reaction of Escherichia coli DNA gyrase on pBR322 in vivo as revealed by oxolinic acid-induced plasmid linearizationQ43785093
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040 II. Structure elucidation and biosynthesisQ43996029
The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanismQ44019092
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activitiesQ48744539
The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.Q52399144
DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action.Q53464975
Conformational changes in DNA gyrase revealed by limited proteolysis.Q53947449
Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein.Q54607440
The Effects of Metal Ions on the Structure and Stability of the DNA Gyrase B ProteinQ59694958
The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†Q59695045
Domain Structure of Escherichia coli DNA Gyrase As Revealed by Differential Scanning CalorimetryQ59695058
On the mechanism of action of quinolone drugsQ60710070
Microbial growth and production kinetics of Streptomyces antibioticus Tü 6040Q73956986
Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tue 6040. II. Structure Elucidation and Biosynthesis.Q78429069
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)213-220
P577publication date2009-10-26
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleMapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.
P478volume54

Reverse relations

cites work (P2860)
Q27681978A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of Inhibition
Q35791501Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target
Q34214929Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
Q28828721Identification of novel bacterial DNA gyrase inhibitors: An in silico study
Q37694351In front of and behind the replication fork: bacterial type IIA topoisomerases.
Q36158288Protective effect of Qnr on agents other than quinolones that target DNA gyrase
Q35680284SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors
Q46263843Structural insights into simocyclinone as an antibiotic, effector ligand, and substrate
Q49832269Topoisomerases as anticancer targets

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