Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors

scientific article published on 8 September 2015

Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/ACSMEDCHEMLETT.5B00266
P932PMC publication ID4601062
P698PubMed publication ID26487916

P2093author name stringJing Zhang
Bin Wang
Dominic Ryan
Anu Daniel
Blaise Lippa
Brian Chamberlain
Chester A Metcalf
Douglas Bevan
Felix Epie
Jan Antoinette C Romero
Jared Silverman
Joseph Shotwell
Katherine M Poutsiaka
Kien Nguyen
Nicole Carter
Qingyi Yang
Roland E Dolle
Terence Moy
Vipul Kumar
Jason Cross
Anu Arya
Yuchuan Wu
P2860cites workDiscovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyraseQ27660378
Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agentsQ28538023
Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screeningQ31406783
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agentsQ36907300
Prospects for developing new antibacterials targeting bacterial type IIA topoisomerases.Q38162903
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallographyQ41064279
5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.Q43291231
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationshipQ44006954
Structure-activity relationship (SAR): effort towards blocking N-glucuronidation of indazoles (PF-03376056) by human UGT1A enzymesQ46056539
A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial propertiesQ83570903
P433issue10
P304page(s)1080-1085
P577publication date2015-09-08
P1433published inACS Medicinal Chemistry LettersQ2819061
P1476titleDiscovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors
P478volume6

Reverse relations

cites work (P2860)
Q48266288Design, Synthesis, and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors.
Q35994500Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Q57265865New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity
Q91666978Synthesis and biological evaluation against Leishmania donovani of novel hybrid molecules containing indazole-based 2-pyrone scaffolds
Q46478240Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis
Q38855273Targeting bacterial topoisomerases: how to counter mechanisms of resistance
Q47743532cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339.

Search more.