Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase

scientific article published on 07 October 2013

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BSR20130083
P932PMC publication ID3791872
P698PubMed publication ID24001138
P5875ResearchGate publication ID256423976

P50authorMatthew L BochmanQ56512233
Nicholas E SimonQ87873685
P2093author name stringJeffrey L Brodsky
William L Seibel
Anthony Schwacha
Sandlin Seguin
P2860cites workDNA replication in nucleus-free Xenopus egg extracts.Q48717515
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Organization of the archaeal MCM complex on DNA and implications for the helicase mechanismQ63383571
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Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiaeQ73430535
Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in ratsQ84236981
Targeting DNA topoisomerase II in cancer chemotherapyQ24649711
Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.Q27936414
Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.Q27936973
Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysisQ27937685
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Subcellular localization of yeast CDC46 varies with the cell cycleQ27940010
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Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replicationQ28210357
Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted 6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acidsQ28324581
The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.Q34189297
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
DNA helicases, genomic instability, and human genetic diseaseQ34433412
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Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancerQ35074445
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Targeting the checkpoint kinases: chemosensitization versus chemoprotectionQ35679781
Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic studyQ35800437
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferationQ36580588
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The Mcm complex: unwinding the mechanism of a replicative helicase.Q37451513
Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicaseQ38354129
Chemical probes of the mitochondrial ATP synthesis and translocationQ39382923
Overexpression of MCM2 in myelodysplastic syndromes: association with bone marrow cell apoptosis and peripheral cytopeniaQ39437549
Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones.Q40132770
Yeast multidrug resistance: The PDR networkQ40456793
Expression of SV40 large T antigen in baculovirus systems and purification by immunoaffinity chromatographyQ40937943
Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability.Q41881445
Ciprofloxacin-induced G2 arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formationQ41911570
Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agentsQ41939932
Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesisQ42491680
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.Q42702121
High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon.Q42984520
Herpes simplex virus helicase-primase inhibitors are active in animal models of human diseaseQ43943693
Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigenQ45082909
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P577publication date2013-10-07
P1433published inBioscience ReportsQ2790714
P1476titleCiprofloxacin is an inhibitor of the Mcm2-7 replicative helicase
P478volume33

Reverse relations

cites work (P2860)
Q101116526Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness
Q38211627Helicases, G4-DNAs, and drug design
Q89975997History of DNA Helicases
Q42212171Identification of inhibitors of Plasmodium falciparum RuvB1 helicase using biochemical assays
Q37656224Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer.
Q56476152New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy
Q35140796Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
Q64124749Post-Translational Modifications of the Mini-Chromosome Maintenance Proteins in DNA Replication
Q26861945Roles of DNA helicases in the maintenance of genome integrity
Q52322877The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.
Q26861045The Mcm2-7 replicative helicase: a promising chemotherapeutic target

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