In vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase

scientific article published on 21 August 2014

In vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/00498254.2014.952799
P698PubMed publication ID25142218

P2093author name stringJian Guo
Fei Zhou
Gregory S Basarab
Camil Joubran
Karthick Vishwanathan
Ricardo A Luzietti
P2860cites workEmerging mechanisms of fluoroquinolone resistanceQ24644842
Structure and mechanism of DNA topoisomerase IIQ27732221
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitorsQ33339829
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groupsQ35758905
A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering systemQ35821755
The gastrointestinal microbiota as a site for the biotransformation of drugsQ37235756
Bacterial DNA replication enzymes as targets for antibacterial drug discoveryQ37998090
Does mutation in gyrA and/or parC or efflux pump expression play the main role in fluoroquinolone resistance in Escherichia coli urinary tract infections?: A statistical analysis studyQ44439017
Synthesis of (-)-PNU-286607 by asymmetric cyclization of alkylidene barbituratesQ44556801
Fluoroquinolones: mechanisms of action and resistance.Q54249946
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)158-170
P577publication date2014-08-21
P1433published inXenobioticaQ1360678
P1476titleIn vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase
P478volume45