Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis

scientific article published on 06 March 2007

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BMCL.2007.03.003
P698PubMed publication ID17368897

P50authorKaren J ShawQ56999092
P2093author name stringRonald Wolin
John J M Wiener
Michael D Hack
Todd K Jones
Jiejun Wu
Brian J Morrow
Cheryl A Grice
S Timothy Motley
Laurent Gomez
Hari Venkatesan
Alejandro Santillán
Daniel J Pippel
Neelakandha Mani
P433issue10
P1104number of pages5
P304page(s)2723-2727
P577publication date2007-03-06
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleNovel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis
P478volume17

Reverse relations

cites work (P2860)
Q35791501Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target
Q33793074Challenges of antibacterial discovery
Q39078552DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens.
Q39055807Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as aurora kinase inhibitors.
Q64081391Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents
Q34214929Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
Q37119995In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase
Q37694351In front of and behind the replication fork: bacterial type IIA topoisomerases.
Q34931378N-Benzyl-3-sulfonamidopyrrolidines are a New Class of Bacterial DNA Gyrase Inhibitors
Q28241966One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives
Q27644560Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents
Q37792983Possible structural and functional determinants contributing to the clastogenicity of pharmaceuticals
Q52656083The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.
Q49832269Topoisomerases as anticancer targets
Q89573603Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs)
Q27663884Type IIA topoisomerase inhibition by a new class of antibacterial agents

Search more.