Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit.

scientific article published on 30 April 2013

Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMCL.2013.04.055
P8608Fatcat IDrelease_b5z7plclbrdwtiygssoicaxubu
P932PMC publication ID3691018
P698PubMed publication ID23664213

P2093author name stringBing Li
Daniel Aiello
Donald T Moir
Norton P Peet
Terry L Bowlin
Ramdas Pai
Marjorie H Barnes
Ming Di
P2860cites workInhibition of DNA helicase, ATPase and DNA-binding activities of E. coli RecQ helicase by chemotherapeutic agents.Q54426102
Methicillin-ResistantS. aureusInfections among Patients in the Emergency DepartmentQ55897489
Time-Resolved Fluorescence Energy Transfer DNA Helicase Assays for High Throughput ScreeningQ73851674
Development of a novel helicase assay using electrochemiluminescenceQ73927470
FlashPlate scintillation proximity assays for characterization and screening of DNA polymerase, primase, and helicase activitiesQ77068313
Myricetin inhibits Escherichia coli DnaB helicase but not primaseQ81240209
Inhibition of DNA helicases with DNA-competitive inhibitorsQ81510750
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicaseQ24548452
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primaseQ27648844
The hexameric helicase DnaB adopts a nonplanar conformation during translocation.Q27673737
Homogenous assays for Escherichia coli DnaB-stimulated DnaG primase and DnaB helicase and their use in screening for chemical inhibitorsQ31055527
Triaminotriazine DNA helicase inhibitors with antibacterial activityQ33229184
Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicasesQ33455209
Inhibitors of DNA polymerase III as novel antimicrobial agents against gram-positive eubacteriaQ33977434
Structure and function of hexameric helicases.Q34019405
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
Coumarin-based inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicase: chemical optimization, biological evaluation, and antibacterial activitiesQ36492284
High-throughput determination of mode of inhibition in lead identification and optimizationQ38449116
Low frequencies of resistance among Staphylococcus and Enterococcus species to the bactericidal DNA polymerase inhibitor N(3)-hydroxybutyl 6-(3'-ethyl-4'-methylanilino) uracilQ39671152
Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanineQ40527605
New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assayQ41358370
Inhibition of bacterial DNA replication by 6-(p-hydroxy-phenylazo)-uracil.Q42232459
Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001).Q43830712
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3481-3486
P577publication date2013-04-30
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleOptimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit.
P478volume23

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cites work (P2860)
Q28075453Alternative pre-approved and novel therapies for the treatment of anthrax
Q35877840Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members
Q92478635Blocking the Trigger: Inhibition of the Initiation of Bacterial Chromosome Replication as an Antimicrobial Strategy
Q46478240Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis
Q52322877The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.

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