Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance

scientific article

Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.47.3.1037-1046.2003
P932PMC publication ID149296
P698PubMed publication ID12604539

P2093author name stringPaul S Charifson
Trudy H Grossman
Stephen P Chambers
William Markland
Martyn Botfield
Maureen Dwyer
Christian H Gross
Jonathan D Parsons
Steven Bellon
Scott A Raybuck
James Jernee
P2860cites workA model for the mechanism of strand passage by DNA gyraseQ24675025
Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic centerQ27621859
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic studyQ27741104
Locking the ATP-operated clamp of DNA gyrase: probing the mechanism of strand passageQ32124532
Type II topoisomerase mutations in fluoroquinolone-resistant clinical strains of Pseudomonas aeruginosa isolated in 1998 and 1999: role of target enzyme in mechanism of fluoroquinolone resistanceQ33982709
Resistance to antibiotics mediated by target alterationsQ34339223
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.Q34493198
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyraseQ35042255
Energy coupling in DNA gyrase and the mechanism of action of novobiocinQ35994466
gyrB mutations in coumermycin A1-resistant Borrelia burgdorferiQ36107774
DNA sequence of the E. coli gyrB gene: application of a new sequencing strategyQ36115385
Identifying the catalytic residue of the ATPase reaction of DNA gyraseQ36697175
Isolation and characterization of Bacillus subtilis genes involved in siderophore biosynthesis: relationship between B. subtilis sfpo and Escherichia coli entD genesQ36773698
Conversion of DNA gyrase into a conventional type II topoisomeraseQ37039334
An unusual mechanism for resistance to the antibiotic coumermycin A1Q37603477
Mutations in the B subunit of Escherichia coli DNA gyrase that affect ATP-dependent reactionsQ38358833
Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining regionQ39478070
Isolation and characterisation of a strain carrying a conditional lethal mutation in the cou gene of Escherichia coli K12Q39588522
Probing the role of the ATP-operated clamp in the strand-passage reaction of DNA gyraseQ39718513
GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.Q39781947
Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistanceQ39837651
Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteriaQ39938412
Evidence for a conformational change in the DNA gyrase-DNA complex from hydroxyl radical footprintingQ40399549
DNA gyrase action involves the introduction of transient double-strand breaks into DNAQ40602513
Inactivation of antibiotics and the dissemination of resistance genesQ40737331
Prevention of drug access to bacterial targets: permeability barriers and active effluxQ40737334
DNA gyrase as a drug targetQ40902870
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallographyQ41064279
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinaseQ42029877
Identification of a residue involved in transition-state stabilization in the ATPase reaction of DNA gyraseQ47870352
The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.Q52399144
Timely release of both replication forks from oriC requires modulation of origin topology.Q52933818
Locking the DNA gate of DNA gyrase: investigating the effects on DNA cleavage and ATP hydrolysis.Q53921739
Probing the two-gate mechanism of DNA gyrase using cysteine cross-linking.Q53923658
Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance.Q54127765
gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.Q54269895
Probing the Binding of Coumarins and Cyclothialidines to DNA Gyrase†Q57980003
Hydrolysis of ATP at Only One GyrB Subunit Is Sufficient to Promote Supercoiling by DNA GyraseQ57980006
The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription 1 1J. KarnQ59695031
Exploiting Nucleotide Thiophosphates To Probe Mechanistic Aspects ofEscherichia coliDNA Gyrase†Q59695033
The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†Q59695045
The DNA dependence of the ATPase activity of DNA gyraseQ59695110
Coumermycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterizationQ67487230
The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerasesQ67505712
Regulation of the genes for E. coli DNA gyrase: Homeostatic control of DNA supercoilingQ70157448
DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanismQ72428717
Mechanisms of fluoroquinolone resistanceQ74371163
Spontaneous cAMP-dependent derepression of gene expression in stationary phase plays a role in recombinant expression instabilityQ74386329
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P1104number of pages10
P304page(s)1037-1046
P577publication date2003-03-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleActive-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance
P478volume47

Reverse relations

cites work (P2860)
Q367690943D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors
Q33796345A high-throughput fluorescence polarization assay for inhibitors of gyrase B
Q24567584Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase
Q43111811DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties
Q45059162DNA gyrase is involved in chloroplast nucleoid partitioning.
Q41822811Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
Q64941577Effects of Lysozyme on the Activity of Ionic of Fluoroquinolone Species.
Q34214929Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
Q37694351In front of and behind the replication fork: bacterial type IIA topoisomerases.
Q34510396In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class
Q21146381Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter species
Q37519599Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance
Q27685473Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion
Q36158288Protective effect of Qnr on agents other than quinolones that target DNA gyrase
Q33584190Real-time visualization of photochemically induced fluorescence of 8-halogenated quinolones: lomefloxacin, clinafloxacin and Bay3118 in live human HaCaT keratinocytes
Q39492541SiO2@Fe2O3 core-shell nanoparticles for covalent immobilization and release of sparfloxacin drug.
Q45752554Silver(I) complexes as precursors to produce silver nanowires: structure characterization, antimicrobial activity and cell viability
Q39117573The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA).
Q55227172Why Two? On the Role of (A-)Symmetry in Negative Supercoiling of DNA by Gyrase.

Search more.