GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.

scientific article published on April 1996

GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.40.4.1060
P932PMC publication ID163264
P698PubMed publication ID8849232

P2093author name stringAngehrn P
Stieger M
Gmünder H
Wohlgensinger B
P2860cites work4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reactionQ40085967
Cyclothialidine and its congeners: a new class of DNA gyrase inhibitorsQ40667220
Cloning and characterization of a DNA gyrase B gene from Streptomyces sphaeroides that confers resistance to novobiocinQ41875356
Deoxyribonucleic acidgyrase-deoxyribonucleic acid complex containing 140 base pairs of deoxyribonucleic acid and an .alpha.2.beta.2 protein coreQ44056419
Preliminary crystallographic analysis of the ATP-hydrolysing domain of the Escherichia coli DNA gyrase B proteinQ45203137
Cyclothialidine, a novel DNA gyrase inhibitor. I. Screening, taxonomy, fermentation and biological activity.Q48798251
The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.Q52399144
gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.Q54269895
Probing the limits of the DNA breakage-reunion domain of the Escherichia coli DNA gyrase A protein.Q54700296
Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B ProteinQ59695056
The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugsQ59695062
DNA topoisomerasesQ70095180
Mapping the active site tyrosine of Escherichia coli DNA gyraseQ70170795
Cyclothialidine, a novel DNA gyrase inhibitor. II. Isolation, characterization and structure elucidationQ72272344
Characterization of the binding site for cyclothialidine on the B subunit of DNA gyraseQ72315721
Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.Q33742392
DNA gyrase: an enzyme that introduces superhelical turns into DNAQ34013173
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.Q34493198
DNA gyrase: structure and function.Q34507230
Fluoroquinolone antimicrobial agentsQ34613302
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyraseQ35042255
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutationsQ35810189
Energy coupling in DNA gyrase and the mechanism of action of novobiocinQ35994466
Characterization of a gyrB mutation responsible for low-level nalidixic acid resistance in Neisseria gonorrhoeaeQ36753284
DNA gyrase: subunit structure and ATPase activity of the purified enzymeQ37596172
An unusual mechanism for resistance to the antibiotic coumermycin A1Q37603477
Structure-activity relationships in DNA gyrase inhibitorsQ37902823
Inhibitors of DNA gyraseQ38333670
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coliQ39816339
Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistanceQ39837651
A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complexQ39864841
Biological characterization of cyclothialidine, a new DNA gyrase inhibitorQ39883723
Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureusQ39928815
Nucleotide sequence of the Staphylococcus aureus gyrB-gyrA locus encoding the DNA gyrase A and B proteinsQ39936506
Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteriaQ39938412
DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coliQ39952187
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectStaphylococcus aureusQ188121
P304page(s)1060-1062
P577publication date1996-04-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleGyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin
P478volume40

Reverse relations

cites work (P2860)
Q34446438Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus
Q39731838Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance
Q54111068Adaptive acquisition of novobiocin resistance in Pasteurella multocida strains of avian origin.
Q33921234Antimicrobial resistance in Staphylococcus aureus
Q51824682Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin.
Q37335706Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases
Q30988207Brachyspira (Serpulina) hyodysenteriae gyrB mutants and interstrain transfer of coumermycin A(1) resistance
Q40902870DNA gyrase as a drug target
Q41822811Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
Q34214929Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.
Q45005861Fitness cost, gyrB mutation, and absence of phosphotransferase system fructose specific IIABC component in novobiocin-resistant Streptococcus iniae vaccine strain ISNO.
Q93083428Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes
Q47722715Identification of gyrB and rpoB gene mutations and differentially expressed proteins between a novobiocin-resistant Aeromonas hydrophila catfish vaccine strain and its virulent parent strain
Q41668866In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria
Q34510396In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class
Q42631623Molecular characterization of the gyrB region of the oral spirochete, Treponema denticola
Q33701326Mutations in Bartonella bacilliformis gyrB confer resistance to coumermycin A1.
Q33690598Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity
Q39731985Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin
Q28534970Synthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives
Q47932274The genome of Staphylococcus aureus: a review

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