Synthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives

scientific article (publication date: 2013)

Synthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...869751S
P356DOI10.1371/JOURNAL.PONE.0069751
P932PMC publication ID3726784
P698PubMed publication ID23922790
P5875ResearchGate publication ID255695772

P2093author name stringJian Ma
Yong Yin
Juan Sun
Hai-Liang Zhu
Peng-Cheng Lv
Rong-Ju Yuan
P2860cites workDetailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm.Q51638510
Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitorsQ67487981
Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potencyQ68790116
Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitorsQ73715175
Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitorsQ79463900
Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivativesQ80667514
Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivativesQ83194138
Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitorsQ27681375
The ATP-binding site of type II topoisomerases as a target for antibacterial drugsQ28207771
Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VIQ28486816
Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screeningQ31406783
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
Quinolone-mediated bacterial death.Q36921143
Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells.Q39502262
Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogsQ39685549
Effect of pyrimido[1,6-a]benzimidazoles, quinolones, and Ca2+ on the DNA gyrase-mediated cleavage reactionQ39778933
GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.Q39781947
Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerasesQ39783230
Bacillus subtilis DNA gyrase: purification of subunits and reconstitution of supercoiling activity.Q39984402
Molecular modeling of Mycobacterium tuberculosis DNA gyrase and its molecular docking study with gatifloxacin inhibitorsQ43189991
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents.Q44819637
Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activityQ44882663
Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivativesQ44950140
Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ringQ45090629
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agentsQ46391026
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e69751
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleSynthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives
P478volume8

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cites work (P2860)
Q48266288Design, Synthesis, and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors.
Q54297794Synthesis, and antibacterial activity of novel 4,5-dihydro-1H-pyrazole derivatives as DNA gyrase inhibitors.

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