NMR structural characterization of the N-terminal active domain of the gyrase B subunit fromPseudomonas aeruginosaand its complex with an inhibitor

article

NMR structural characterization of the N-terminal active domain of the gyrase B subunit fromPseudomonas aeruginosaand its complex with an inhibitor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.FEBSLET.2015.07.044
P698PubMed publication ID26272827

P50authorThomas H. KellerQ55174967
Joseph CherianQ55345579
CongBao KangQ56373648
Yan LiQ37367255
P2093author name stringHui Qi Ng
Jeffrey Hill
Michelle Yueqi Lee
Ying Lei Wong
Boping Liu
Yun Xuan Wong
Zhi Ying Poh
Alvin W. Hung
P2860cites workA journey in the world of DNA rings and beyondQ38571383
NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complexQ40254020
In silico discovery of 2-amino-4-(2,4-dihydroxyphenyl)thiazoles as novel inhibitors of DNA gyrase B.Q43203280
Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.Q44422605
DNA topoisomerases: structure, function, and mechanismQ22065417
Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyraseQ24567584
TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shiftsQ24651272
DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the novioseQ27639067
Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolutionQ27640255
Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitorsQ27681375
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IVQ27681781
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activityQ27683826
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agentsQ27686938
Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channelQ27689490
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agentsQ28306539
Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agentsQ28538023
Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nucleaseQ29547582
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary informationQ29615720
Discovering high-affinity ligands for proteins: SAR by NMRQ29617569
Challenges of antibacterial discoveryQ33793074
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Q34214929
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.Q34493198
DNA gyrase: structure and function.Q34507230
NMR scalar couplings across Watson-Crick base pair hydrogen bonds in DNA observed by transverse relaxation-optimized spectroscopyQ36730288
TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteinsQ36793550
Using chemical shift perturbation to characterise ligand bindingQ38130403
P433issue19PartB
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
cell biologyQ7141
molecular biologyQ7202
structural biologyQ908902
P304page(s)2683-2689
P577publication date2015-08-10
P1433published inFEBS LettersQ1388051
P1476titleNMR structural characterization of the N-terminal active domain of the gyrase B subunit fromPseudomonas aeruginosaand its complex with an inhibitor
P478volume589

Reverse relations

cites work (P2860)
Q54258536Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit.
Q48238344Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor
Q40356984Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor
Q41046166Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy
Q38612644Solution NMR Spectroscopy in Target-Based Drug Discovery

Search more.