ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence

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ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...999983L
P356DOI10.1371/JOURNAL.PONE.0099983
P932PMC publication ID4061041
P698PubMed publication ID24937130
P5875ResearchGate publication ID263165380

P2093author name stringDavid A Boothman
Sally A Amundson
Shanaz A Ghandhi
Masatoshi Suzuki
Xiuquan Luo
P2860cites workSenescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretionQ40149352
Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor.Q40462263
Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stressQ40583114
Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblastsQ40812808
Differential regulation of the clusterin gene by Ha-ras and c-myc oncogenes and during apoptosisQ40965083
Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway.Q41783574
Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblastsQ43438241
Signal transduction in H2O2-induced senescence-like phenotype in human diploid fibroblastsQ44207279
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.Q52827047
Clusterin plays an important role in hepatocellular carcinoma metastasisQ58321603
Premature senescence of mesothelial cells is associated with non-telomeric DNA damageQ60284588
Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblastsQ77346198
High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathwaysQ79856384
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Q24293520
Clusterin inhibits apoptosis by interacting with activated BaxQ24316499
Induction of premature senescence by hsp90 inhibition in small cell lung cancerQ28474354
ATM and related protein kinases: safeguarding genome integrityQ29547735
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighborsQ29614306
Cellular senescence: when bad things happen to good cellsQ29615561
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.Q33293671
Caveolin-1, cellular senescence and pulmonary emphysemaQ33627898
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and agingQ33946993
Clusterin/apolipoprotein J in human aging and cancerQ34146411
Oxidative DNA damage and senescence of human diploid fibroblast cells.Q34323707
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancerQ34453304
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulationQ35816507
Human cell senescence as a DNA damage response.Q35989854
The ATM-dependent DNA damage signaling pathwayQ36547714
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells.Q37033622
Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapyQ37064796
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescenceQ37068403
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.Q37345878
The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-reviewQ37527534
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.Q37569714
ATM protein kinase: the linchpin of cellular defenses to stressQ37870855
Never-ageing cellular senescenceQ37874368
ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instabilityQ39499677
Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescenceQ39678828
Proteomic analysis of plasma proteins in Japanese semisuper centenariansQ39827156
c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.Q40025608
Hsp27 modulates p53 signaling and suppresses cellular senescenceQ40033614
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)e99983
P577publication date2014-01-01
P1433published inPLOS OneQ564954
P1476titleATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence
P478volume9

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cites work (P2860)
Q57806939Ataxia telangiectasia alters the ApoB and reelin pathway
Q36357809Body composition, muscle strength and hormonal status in patients with ataxia telangiectasia: a cohort study
Q38383224Cellular senescence: from growth arrest to immunogenic conversion
Q42200953Clusterin modulates transdifferentiation of non-small-cell lung cancer
Q41491991Diagnostic and prognostic significance of secretory clusterin expression in patients with hepatocellular carcinoma
Q38932832Efficient and sustained IGF-1 expression in the adipose tissue-derived stem cells mediated via a lentiviral vector
Q37203685Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases
Q46309597Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders
Q41592701Oncogenic secretory clusterin in hepatocellular carcinoma: Expression at early staging and emerging molecular target
Q34773915Serum clusterin as a tumor marker and prognostic factor for patients with esophageal cancer
Q49175511WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation

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