| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2010PLoSO...511076R |
| P356 | DOI | 10.1371/JOURNAL.PONE.0011076 |
| P932 | PMC publication ID | 2884022 |
| P698 | PubMed publication ID | 20552022 |
| P5875 | ResearchGate publication ID | 44676999 |
| P2093 | author name string | Ian A J Lorimer | |
| Ian J Restall | |||
| P2860 | cites work | Feedback between p21 and reactive oxygen production is necessary for cell senescence | Q24299631 |
| Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4 | Q24322569 | ||
| Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 | Q24647585 | ||
| Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90 | Q28143497 | ||
| Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA | Q28300188 | ||
| DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90 | Q28376524 | ||
| Structure and mechanism of the Hsp90 molecular chaperone machinery | Q29615146 | ||
| Cellular senescence: when bad things happen to good cells | Q29615561 | ||
| A DNA damage checkpoint response in telomere-initiated senescence | Q29615919 | ||
| Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence | Q29620428 | ||
| Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study | Q33377626 | ||
| Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel | Q33571026 | ||
| The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties | Q33888203 | ||
| Senescence-associated beta-galactosidase is lysosomal beta-galactosidase | Q33995193 | ||
| The Hsp90 molecular chaperone: an open and shut case for treatment | Q34753043 | ||
| The Hsp90 chaperone machinery | Q34774579 | ||
| Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90. | Q34792400 | ||
| Hallmarks of senescence in carcinogenesis and cancer therapy | Q35743144 | ||
| Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. | Q53600237 | ||
| Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Ciota-mediated attenuation of p38 MAP kinase signaling. | Q55470737 | ||
| Genetic interactions between Hsp90 and the Cdc2 mitotic machineryin the fission yeast Schizosaccharomyces pombe | Q58181568 | ||
| Small Cell Lung Cancer | Q60307382 | ||
| Ins and outs of tumour control | Q62336468 | ||
| Geldanamycin induces cell cycle arrest in K562 erythroleukemic cells | Q73347967 | ||
| Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest | Q74088099 | ||
| A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy | Q74117541 | ||
| p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53 | Q77853882 | ||
| A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents | Q78125095 | ||
| Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer | Q81414742 | ||
| Cellular senescence and cancer treatment. | Q36616891 | ||
| Cellular senescence and chromatin structure | Q36853695 | ||
| Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells | Q37120694 | ||
| The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation | Q37127277 | ||
| Targeting Hsp90: small-molecule inhibitors and their clinical development | Q37222845 | ||
| Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. | Q37494634 | ||
| The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity. | Q38313087 | ||
| Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence | Q39647108 | ||
| Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation | Q39957013 | ||
| Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. | Q40063505 | ||
| Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer | Q40113117 | ||
| Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells | Q40128062 | ||
| Hsp90 regulates the Fanconi anemia DNA damage response pathway | Q40165693 | ||
| Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition | Q40355248 | ||
| A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors | Q40631570 | ||
| Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. | Q40684830 | ||
| Small cell lung cancer: etiology, biology, clinical features, staging, and treatment | Q40857450 | ||
| Cell cycle checkpoint evasion and protracted cell cycle arrest in X-irradiated small-cell lung carcinoma cells | Q40915532 | ||
| Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones | Q40930400 | ||
| Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. | Q42492406 | ||
| Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner | Q45003967 | ||
| Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors. | Q46387525 | ||
| Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies | Q46551678 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | lung cancer | Q47912 |
| P304 | page(s) | e11076 | |
| P577 | publication date | 2010-06-11 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Induction of premature senescence by hsp90 inhibition in small cell lung cancer | |
| P478 | volume | 5 |
| Q35206531 | 17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway |
| Q42281696 | 17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells |
| Q34807689 | A kinase shRNA screen links LATS2 and the pRB tumor suppressor |
| Q37327734 | A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation |
| Q33911201 | A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death |
| Q28539773 | ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence |
| Q36483749 | Broad targeting of resistance to apoptosis in cancer. |
| Q36095375 | Differential expression of heat shock protein 90 isoforms in small cell lung cancer |
| Q38735183 | Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series |
| Q36956034 | HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells |
| Q37718247 | Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer |
| Q38687525 | Sublethal heat shock induces premature senescence rather than apoptosis in human mesenchymal stem cells. |
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