17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway

scientific article

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JCMM.12469
P932PMC publication ID4369821
P698PubMed publication ID25712415
P5875ResearchGate publication ID272841038

P2093author name stringShun Lu
Xiang-Yun Ye
Yun-Hua Xu
Zhi-Wei Chen
Zi-Ming Li
Xiao-Min Niu
Sheng-Ping Shen
Qing-Quan Luo
Nai-Wang Tang
P2860cites workUpregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patientsQ21198841
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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancersQ28237942
Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential targetQ28271520
HSP90 inhibitors for cancer therapy and overcoming drug resistanceQ28274601
Induction of premature senescence by hsp90 inhibition in small cell lung cancerQ28474354
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.Q28972461
Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1Q30417692
17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cellsQ33688498
Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancerQ33710107
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluationQ34102029
Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.Q34268075
The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cellsQ34407501
Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumorsQ35064987
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.Q35636555
Hypermethylation of the large tumor suppressor genes in Japanese lung cancerQ36216645
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Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion.Q36724951
Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinomaQ36898402
Expression of Transforming Growth Factor β1 and E-Cadherin Proteins in Pulmonary Adenocarcinoma: Its Significance in Tumor ProgressionQ37011129
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammalsQ37105079
Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic miceQ37316361
LATS tumor suppressor: A new governor of cellular homeostasisQ37799215
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Heat shock proteins: a potential anticancer targetQ37903364
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Expression of Yes-associated protein in gastric adenocarcinoma and inhibitory effects of its knockdown on gastric cancer cell proliferation and metastasisQ39261184
17-Allylamino-17-demethoxygeldanamycin and ritonavir inhibit renal cancer growth by inhibiting the expression of heat shock factor-1.Q39370346
Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance.Q39429490
Cell-cell junctions: α-catenin and E-cadherin help fence in Yap1.Q39444842
Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cellsQ39464528
Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer.Q40278675
Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumorsQ40611434
The role of the hippo pathway in melanocytes and melanomaQ40748577
LATS1 tumor suppressor regulates G2/M transition and apoptosisQ40750103
Immunohistochemical alpha- and beta-catenin and E-cadherin expression and their clinicopathological significance in human lung adenocarcinoma.Q53235591
Molecular alterations of E-cadherin and beta-catenin in brain metastases.Q54394542
A breakdown of the Hippo pathway in gastric cancer.Q54557654
P433issue3
P921main subjectadenocarcinomaQ356033
P304page(s)651-663
P577publication date2015-03-01
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476title17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway
P478volume19

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cites work (P2860)
Q92981987Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model
Q38695460Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells
Q92454757Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC)
Q52682024Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury.
Q37085989Loss of large tumor suppressor 1 promotes growth and metastasis of gastric cancer cells through upregulation of the YAP signaling
Q60908274The Role of Yes-Associated Protein (YAP) in Regulating Programmed Death-Ligand 1 (PD-L1) in Thoracic Cancer
Q47230489YAP Is Decreased in Preeclampsia and Regulates Invasion and Apoptosis of HTR-8/SVneo
Q97540643Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ): a nexus between hypoxia and cancer

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