The bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin, a secoiridoid glycoside from Swertia chirayita

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The bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin, a secoiridoid glycoside from Swertia chirayita is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...990637S
P356DOI10.1371/JOURNAL.PONE.0090637
P932PMC publication ID3946170
P698PubMed publication ID24603686
P5875ResearchGate publication ID260610876

P50authorKhushboo BafnaQ59692215
Shantanu ShuklaQ59692225
P2093author name stringDurai Sundar
Sunil S Thorat
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The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentinQ35007309
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Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) KarstQ44346144
Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis modelQ44918518
Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis modelQ46975485
Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in ratsQ48768392
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.Q52518083
MMPBSA decomposition of the binding energy throughout a molecular dynamics simulation of amyloid-beta (Abeta(10-35)) aggregation.Q64964970
Aspirin selectively inhibits prostaglandin production in human plateletsQ71062251
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Prevention of liver carcinogenesis by amarogentin through modulation of G1/S cell cycle check point and induction of apoptosisQ84935327
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectSwertia chirayitaQ21318003
P304page(s)e90637
P577publication date2014-03-06
P1433published inPLOS OneQ564954
P1476titleThe bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin, a secoiridoid glycoside from Swertia chirayita
P478volume9

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Q57287548Differential Substrate Recognition by Maltose Binding Proteins Influenced by Structure and Dynamics
Q115707320Integrative Analytical and Computational Strategies for Qualitative and Semi-quantitative Plant Metabolome Characterization

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