PCR-based assays versus direct sequencing for evaluating the effect of KRAS status on anti-EGFR treatment response in colorectal cancer patients: a systematic review and meta-analysis

scientific article

PCR-based assays versus direct sequencing for evaluating the effect of KRAS status on anti-EGFR treatment response in colorectal cancer patients: a systematic review and meta-analysis is …
instance of (P31):
meta-analysisQ815382
scholarly articleQ13442814
systematic reviewQ1504425
review articleQ7318358

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P819ADS bibcode2014PLoSO...9j7926S
P356DOI10.1371/JOURNAL.PONE.0107926
P932PMC publication ID4178055
P698PubMed publication ID25260023
P5875ResearchGate publication ID266241901

P2093author name stringMing Li
Jianzhong Ma
Huidan Zhang
Lianfeng Shan
P2860cites workIncreased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer.Q54585853
Different real time PCR approaches for the fine quantification of SNP's alleles in DNA pools: assays development, characterization and pre-validation.Q54638669
Rapid detection of K-ras mutations in bile by peptide nucleic acid-mediated PCR clamping and melting curve analysis: comparison with restriction fragment length polymorphism analysisQ75244904
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximabQ80704669
Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII studyQ83801480
Molecular origins of cancer: Molecular basis of colorectal cancerQ24617331
PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysisQ26992267
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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.Q27824867
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancerQ27851407
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.Q27851422
K-ras mutations and benefit from cetuximab in advanced colorectal cancer.Q27851454
KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.Q27851616
Extracting summary statistics to perform meta-analyses of the published literature for survival endpointsQ27860640
Meta-analysis in clinical trialsQ27860779
Quantitative and sensitive detection of rare mutations using droplet-based microfluidicsQ28238121
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancerQ28240089
High-throughput droplet digital PCR system for absolute quantitation of DNA copy numberQ28251729
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancerQ28271324
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancerQ28298328
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancerQ28305293
The causes and consequences of genetic heterogeneity in cancer evolutionQ29615848
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancerQ29616236
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME studyQ29619653
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future.Q33903874
Detection of low-level KRAS mutations using PNA-mediated asymmetric PCR clamping and melting curve analysis with unlabeled probesQ33947043
Detection and quantification of mutations in the plasma of patients with colorectal tumorsQ34132363
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.Q34624122
American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapyQ34935716
Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patientsQ34994963
PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer.Q35953893
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapyQ36610301
Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidinesQ36628049
DxS Ltd.Q37126666
The molecular therapy of colorectal cancerQ37695708
Allele-specific real-time PCR system for detection of subpopulations of genotype 1a and 1b hepatitis C NS5B Y448H mutant viruses in clinical samplesQ38284922
Optimized allele-specific real-time PCR assays for the detection of common mutations in KRAS and BRAF.Q38412630
The allele-specific probe and primer amplification assay, a new real-time PCR method for fine quantification of single-nucleotide polymorphisms in pooled DNA.Q40872268
Detection of EGFR mutations by TaqMan mutation detection assays powered by competitive allele-specific TaqMan PCR technologyQ41907272
The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer.Q46140702
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximabQ46903224
Loss of PTEN expression as a predictor of resistance to anti-EGFR monoclonal therapy in metastatic colorectal cancer: evidence from retrospective studies.Q54509870
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
monoclonal antibodyQ422248
ras subfamilyQ424396
ErbB receptorsQ5385089
colorectal neoplasmQ58833976
proto-oncogene proteinQ66020913
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)e107926
P577publication date2014-09-26
P1433published inPLOS OneQ564954
P1476titlePCR-based assays versus direct sequencing for evaluating the effect of KRAS status on anti-EGFR treatment response in colorectal cancer patients: a systematic review and meta-analysis
P478volume9

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cites work (P2860)
Q61814489Colorectal Cancer Prognosis is Not Associated with BRAF and KRAS Mutations-A STROBE Compliant Study
Q39172118Current companion diagnostics in advanced colorectal cancer; getting a bigger and better piece of the pie
Q48009778Detection of Rare Mutations by Routine Analysis of KRAS, NRAS, and BRAF Oncogenes

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