The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01

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The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01 is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1030928H
P356DOI10.1371/JOURNAL.PONE.0130928
P932PMC publication ID4476721
P698PubMed publication ID26098642
P5875ResearchGate publication ID280032198

P50authorKatsunobu HagiharaQ54234768
P2093author name stringTakashi Izumi
Noriko Okudaira
Makoto Hirasawa
P2860cites workGenome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesisQ61781514
Molecular and structural determinants of adamantyl susceptibility to HLA-DRs allelic variants: an in silico approach to understand the mechanism of MLEsQ82663150
Lapatinib-induced liver injury characterized by class II HLA and Gilbert's syndrome genotypesQ83492372
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptideQ24630127
Idiosyncratic adverse drug reactions: current conceptsQ26824391
Immune self-reactivity triggered by drug-modified HLA-peptide repertoireQ27681301
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreadingQ27860652
A semiempirical free energy force field with charge-based desolvationQ29614316
Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocketQ33258637
Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC moleculesQ33324394
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentationQ34063488
Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivityQ34140322
Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injuryQ35136429
Pharmacological interaction of drugs with immune receptors: the p-i concept.Q36639657
Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergyQ42548860
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancerQ43270036
HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancerQ46575159
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e0130928
P577publication date2015-01-01
P1433published inPLOS OneQ564954
P1476titleThe Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01
P478volume10

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cites work (P2860)
Q41640449Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib
Q38824550Drug-Induced Liver Injury: Highlights from a Review of the 2015 Literature
Q92432175HLA-DRB1*07:01 and lapatinib-induced hepatotoxicity: a systematic review and meta-analysis
Q42289978In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01.
Q55667533Interaction of Nevirapine with the Peptide Binding Groove of HLA-DRB1*01:01 and Its Effect on the Conformation of HLA-Peptide Complex.

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