Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells

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Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1041110K
P356DOI10.1371/JOURNAL.PONE.0141110
P3181OpenCitations bibliographic resource ID599105
P932PMC publication ID4619766
P698PubMed publication ID26496360
P5875ResearchGate publication ID283262559

P2093author name stringHoe Suk Kim
Lianji Tian
Woo Kyung Moon
Hyeonjin Kim
Sul Ki Choi
Yujin Sun
Minji Jung
P2860cites workIncreased choline kinase activity in 1,2-dimethylhydrazine-induced rat colon cancer.Q55230988
Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill YouQ60188463
Tamoxifen in the treatment of breast cancerQ77598704
Macroautophagy signaling and regulationQ37608022
The multiple roles of autophagy in cancerQ37840892
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
The role of autophagy in cancer: therapeutic implicationsQ37924056
Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitorsQ39337473
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signalingQ39783619
Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistanceQ39883237
A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistanceQ39940036
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.Q40174892
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistanceQ40253550
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferationQ40344986
Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.Q40635044
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathwayQ40789651
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filamentsQ40895734
Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis.Q42812911
Ras is involved in the negative control of autophagy through the class I PI3-kinaseQ42830028
Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy.Q44653812
Increased choline kinase activity and elevated phosphocholine levels in human colon cancerQ22009964
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceQ24645668
Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapyQ27024127
Mechanisms of disseminated cancer cell dormancy: an awakening fieldQ27027015
Oncogenic kinase signallingQ28189493
Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3KQ28200766
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancersQ28217662
Structure and function of choline kinase isoforms in mammalian cellsQ28248624
Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cellsQ28259789
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progressionQ28282754
Cancer drug resistance: an evolving paradigmQ29616694
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesisQ29617725
Pancreatic cancers require autophagy for tumor growthQ29620331
Pathways to tamoxifen resistanceQ30441001
Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signalsQ30665733
Molecular causes of the aberrant choline phospholipid metabolism in breast cancerQ30939042
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinaseQ33796255
The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.Q33959529
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategyQ34135239
Ki67 protein: the immaculate deception?Q34570709
Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cellsQ35046962
eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.Q35534450
Choline phospholipid metabolism: a target in cancer cells?Q35549481
Autophagy as a cell death and tumor suppressor mechanismQ35743138
Models, mechanisms and clinical evidence for cancer dormancyQ36844303
Deconvoluting the context-dependent role for autophagy in cancerQ36876716
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cellsQ36972761
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
tamoxifenQ412178
P304page(s)e0141110
P577publication date2015-01-01
P1433published inPLOS OneQ564954
P1476titleDownregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells
P478volume10