A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis

scientific journal article

A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2353/AJPATH.2006.050767
P932PMC publication ID1698820
P698PubMed publication ID16936262
P5875ResearchGate publication ID6852841

P2093author name stringFiona Oakley
Derek A. Mann
Grant A. Ramm
Richard G. Ruddell
Irene Yeung
Lesley J. Bryan-Lluka
Ziafat Hussain
P2860cites workAntidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localizationQ24308751
Ritanserin as an adjunct to lithium and haloperidol for the treatment of medication-naive patients with acute mania: a double blind and placebo controlled trialQ24800266
Molecular, pharmacological and functional diversity of 5-HT receptorsQ28206145
Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cellsQ28372756
Insulin-like growth factor (IGF)-binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cellsQ28581666
5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cellsQ28588283
Liver fibrosisQ29547449
Activation of 5-HT receptors that stimulate the adenylyl cyclase pathway positively regulates IGF-I in cultured craniofacial mesenchymal cells.Q31927550
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injuryQ33822590
SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depressionQ33884433
Changes in plasma serotonin concentration and acceleration plethysmograms in patients with Raynaud's phenomenon after long-term treatment with a 5-HT2 receptor antagonistQ33926187
Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in cultureQ34190381
Developmentally regulated serotonin 5-HT2B receptors.Q34264903
Extracellular matrix degradation and the role of hepatic stellate cellsQ34391375
Transcriptional regulation of hepatic stellate cell activationQ34637612
PDGF and signal transduction in hepatic stellate cellsQ34754831
Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT).Q35047597
5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathwaysQ35077547
Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cellsQ35748222
Molecular and functional characterization of proteins interacting with the C-terminal domains of 5-HT2 receptors: emergence of 5-HT2 "receptosomes".Q35811309
Cloning and expression of a functional serotonin transporter from rat brainQ38332277
Cloning and expression of the mouse serotonin transporterQ39758098
Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis.Q40681279
Regulation of serotonin transporter gene expression in human glial cells by growth factorsQ40812966
Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosisQ42132079
Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by Rho proteins and the actin cytoskeletonQ42493036
Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosisQ42600836
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in ratsQ43720079
Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosisQ43858122
Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signalingQ44435280
Gliotoxin ameliorates development of fibrosis and cirrhosis in a thioacetamide rat modelQ44553035
Hepatic microvascular regulatory mechanisms. XII. Effects of 5-HT2-receptor blockade on serotonin-induced intralobular hypoperfusionQ45091566
Relevance of mast cells and hepatic lobule innervation to liver injuryQ45095180
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.Q45212249
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.Q45212253
Antifibrogenic role of the cannabinoid receptor CB2 in the liverQ46376137
Transformation-dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligandQ47720301
Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosisQ47785420
The role of the autonomic nervous system in chemically-induced liver damage and repair--using the essential hypertensive animal model (SHR).Q49167137
Evidence for a storage pool defect in platelets from cirrhotic patients with defective aggregationQ61763141
Platelet and plasma serotonin in patients with liver cirrhosisQ69753867
Ketanserin: a new perspective in posttransplant erythrocytosis?Q71128124
Serotonin regulation of gene expression in uterine extracellular matrix: reciprocal effects on collagens and collagenaseQ71594313
Blood and plasma 5-hydroxytryptamine levels in patients with cirrhosisQ71650336
Anti-mitogenic effects of sarpogrelate in cultured rat mesangial cellsQ73167994
Ileal carcinoid tumor complicating carcinoid heart disease and secondary retroperitoneal fibrosisQ73884341
Induction of DNA synthesis in primary cultures of rat hepatocytes by serotonin: possible involvement of serotonin S2 receptorQ74027092
Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotoninQ74452830
Serotonin enhances the production of type IV collagen by human mesangial cellsQ77394383
5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets functionQ77425309
Serotonin 5-HT2A receptor induces TGF-beta1 expression in mesangial cells via ERK: proliferative and fibrotic signalsQ77855932
Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cellsQ77933562
Serotonin metabolism in rat mesangial cells: involvement of a serotonin transporter and monoamine oxidase AQ93926657
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectserotoninQ167934
cell functionQ95674809
P304page(s)861–876
P577publication date2006-09-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleA role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis
P478volume169

Reverse relations

cites work (P2860)
Q392021425-HT2A receptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis
Q404228805-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin
Q33414941A Preliminary Study on the Relationship between Platelet Serotonin Transporter Functionality, Depression, and Fatigue in Patients with Untreated Chronic Hepatitis C.
Q90351405Accumulation of myeloid lineage cells is mapping out liver fibrosis post injury: a targetable lesion using Ketanserin
Q41167772Activated hepatic stellate cells: negative regulators of hepatocyte proliferation in liver diseases
Q28476430Activation of protein serine/threonine phosphatase PP2Cα efficiently prevents liver fibrosis
Q37353099Advances in antifibrotic therapy
Q36919731Biogenic amine actions on cholangiocyte function
Q37175438Cholangiocyte proliferation and liver fibrosis.
Q26825671Chronic hepatitis C and liver fibrosis.
Q28078684Clinical Advancements in the Targeted Therapies against Liver Fibrosis.
Q56530996Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy
Q42022563Connective tissue growth factor in tumor pathogenesis.
Q38364957Current frontiers in systemic sclerosis pathogenesis.
Q30473375Current status of novel antifibrotic therapies in patients with chronic liver disease
Q38896063Development of resistance to serotonin-induced itch in bile duct ligated mice
Q35460340Effect of 5-HT7 receptor blockade on liver regeneration after 60-70% partial hepatectomy.
Q42703981Effect of Gestational Exposure of Cypermethrin on Postnatal Development of Brain Cytochrome P450 2D1 and 3A1 and Neurotransmitter Receptors
Q38642487Enteric Serotonin and Oxytocin: Endogenous Regulation of Severity in a Murine Model of Necrotizing Enterocolitis
Q34066972Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells
Q34658528Fibrosis and carcinoid syndrome: from causation to future therapy
Q53581215Hepatic fibrosis 2006: report of the Third AASLD Single Topic Conference.
Q35124593Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair
Q29616840Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
Q27310913Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish
Q87669646Liver fibrosis
Q33395901Liver regeneration is promoted by increasing serotonin content in rat liver with secondary biliary cirrhosis
Q37865859Mechanisms of hepatic fibrogenesis
Q39294420Mechanisms of hepatic stellate cell activation
Q92174629Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis
Q41953936Nerve-cancer interactions in the stromal biology of pancreatic cancer
Q41564524Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice
Q34973681Platelet-derived serotonin links vascular disease and tissue fibrosis
Q92081687Platelets as Key Factors in Hepatocellular Carcinoma
Q28071893Platelets: No longer bystanders in liver disease
Q49168017Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?
Q21134750Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake
Q92354635Role of 5-HT7 receptors in the immune system in health and disease
Q33344424Role of iron in hepatic fibrosis: one piece in the puzzle
Q34450683Role of serotonin in development of esophageal and gastric fundal varices
Q33645106Role of serotonin in fatty acid-induced non-alcoholic fatty liver disease in mice
Q97545426Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake
Q47133468Selective serotonin reuptake inhibitors and the risk of hepatocellular carcinoma in hepatitis B virus-infected patients
Q55024386Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments.
Q43122702Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice
Q85830341Serotonin in liver tumor: Friend or foe?
Q38049023Serotonin paracrine signaling in tissue fibrosis
Q36697797Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a.
Q24297176Serotonin promotes tumor growth in human hepatocellular cancer
Q24610679Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease
Q34487150Switching-on of serotonergic calcium signaling in activated hepatic stellate cells.
Q42591676Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.
Q52690372The Role of Serotonin during Skin Healing in Post-Thermal Injury.
Q46429020The effect of terguride in carbon tetrachloride-induced liver fibrosis in rat.
Q33617543The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation
Q34977162Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone
Q90355553Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis
Q37149500Wound healing and local neuroendocrine regulation in the injured liver.

Search more.