Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis

scientific article published on 18 October 2019

Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.30880
P698PubMed publication ID31344280

P50authorRomil SaxenaQ89703970
Pietro InvernizziQ37842572
Heather L. FrancisQ89701375
P2093author name stringNan Wu
Suthat Liangpunsakul
Chaodong Wu
Luca Fabris
Fanyin Meng
Gianfranco Alpini
Konstantina Kyritsi
Tianhao Zhou
Anatoliy A Gashev
Travis W Hein
Julie Venter
Shannon S Glaser
Lixian Chen
Nicholas J Skill
April O'Brien
David Zawieja
Ludovica Ceci
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Platelet-derived serotonin mediates liver regenerationQ28306257
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosisQ28569215
Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in ratsQ28573092
Regulation of cholangiocyte bicarbonate secretionQ34344156
Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.Q34597703
Systemic inflammation alters central 5-HT function as determined by pharmacological MRIQ34615371
Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligationQ34628746
Biogenic amines serotonin and dopamine regulate cholangiocyte hyperplastic and neoplastic growthQ34992316
Effect of 5-HT7 receptor blockade on liver regeneration after 60-70% partial hepatectomy.Q35460340
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Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinomaQ35629462
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Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductulesQ35810064
The CholangiopathiesQ35942610
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Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growthQ36996185
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Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ outputQ37096585
Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in miceQ38332057
Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitroQ38723269
The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in miceQ38775284
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Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.Q39979273
E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 networkQ42289050
Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in miceQ43122702
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.Q45212253
Different properties of the central and peripheral forms of human tryptophan hydroxylaseQ45233007
The effect of terguride in carbon tetrachloride-induced liver fibrosis in rat.Q46429020
Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice.Q46717257
Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.Q47850237
Monoamine oxidase A imaging in peripheral organs in healthy human subjectsQ48296064
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.Q55044281
Ductular reaction in liver diseases: pathological mechanisms and translational significancesQ57112577
Treatment of pruritus in chronic liver disease with the 5-hydroxytryptamine receptor type 3 antagonist ondansetron: a randomized, placebo-controlled, double-blind cross-over trialQ77609350
Serotonin skews human macrophage polarization through HTR2B and HTR7Q85969067
Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in ratsQ87419222
P433issue3
P304page(s)990-1008
P577publication date2019-10-18
P1433published inHepatologyQ15724398
P1476titleModulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis
P478volume71

Reverse relations

cites work (P2860)
Q89701954Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling
Q89797164Cholangiocarcinoma: novel therapeutic targets
Q90110648Histamine-2 Receptor Vivo-Morpholino Treatment Ameliorates Large Bile Duct Damage in Mice Deficient in ATP Binding Cassette Subfamily B Member 4 (Abcb4-/-) via Down-Regulation of cAMP/ERK Signaling
Q89761775Neuroendocrine Changes in Cholangiocarcinoma Growth

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