The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

scientific journal article

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M210456200
P3181OpenCitations bibliographic resource ID325876
P698PubMed publication ID12435734

P2093author name stringLing Xia
Linda Björkhem-Bergman
Ivan Nalvarte
Mikael Björnstedt
Giannis Spyrou
Tomas Nordman
Anastassios Damdimopoulos
Elias S. J. Arnér
Jerker M. Olsson
Lennart C. Eriksson
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Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzymeQ24555780
Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequenceQ24683648
Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductaseQ27863443
Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductaseQ27863449
Cloning, sequencing and functional expression of a novel human thioredoxin reductaseQ28115611
Ubiquinone is reduced by lipoamide dehydrogenase and this reaction is potently stimulated by zincQ28142414
Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutationsQ28581387
High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genesQ28583566
Physiological functions of thioredoxin and thioredoxin reductaseQ29615600
Reactive oxygen species, antioxidants, and the mammalian thioredoxin systemQ29619367
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrationsQ33649683
Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acidQ33781496
Thioredoxin reductase as a pathophysiological factor and drug targetQ34049902
Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins.Q34377761
Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activityQ35076291
The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systemsQ37697007
Regulation of human thioredoxin reductase expression and activity by 3'-untranslated region selenocysteine insertion sequence and mRNA instability elementsQ40932866
Functional expression of rat thioredoxin reductase: selenocysteine insertion sequence element is essential for the active enzymeQ42158832
Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodulesQ43753024
Selenium spares ascorbate and alpha-tocopherol in cultured liver cell lines under oxidant stressQ43812292
Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase.Q43823898
Mutational analysis of human thioredoxin reductase 1. Effects on p53-mediated gene expression and interferon and retinoic acid-induced cell deathQ43959509
Reduction of ubiquinone by lipoamide dehydrogenaseQ56567623
Mismatch Binding Protein-Based Mutation Detection SystemsQ56944697
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)2141–2146
P577publication date2003-01-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress
P478volume278

Reverse relations

cites work (P2860)
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