The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

scientific article published on 22 January 2015

The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDDIS.2014.574
P932PMC publication ID4669772
P698PubMed publication ID25611390
P5875ResearchGate publication ID271331477

P50authorElias ArnérQ5360441
Galina SelivanovaQ50923870
Qing ChengQ54443949
Tatyana SandalovaQ28323251
Ylva LindqvistQ28324830
Péter NagyQ41685167
Charles MyersQ43157823
P2093author name stringJ Xu
U Hellman
W E Antholine
S E Eriksson
E Hedström
M Cebula
I Pader
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The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stressQ28570071
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Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygenQ28627251
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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.Q33209208
Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cellsQ33326607
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Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trappingQ36844094
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Spectroscopic evidence for an engineered, catalytically active Trp radical that creates the unique reactivity of lignin peroxidase.Q37364178
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ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.Q37631181
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A mechanistic investigation of the C-terminal redox motif of thioredoxin reductase from Plasmodium falciparumQ38311040
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Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoproteinQ44646961
Evidence for intriguingly complex transcription of human thioredoxin reductase 1.Q44774494
Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin.Q45584374
Detection of a tryptophan radical as an intermediate species in the reaction of horseradish peroxidase mutant (Phe-221 --> Trp) and hydrogen peroxideQ48010875
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectcell deathQ2383867
P304page(s)e1616
P577publication date2015-01-22
P1433published inCell Death and DiseaseQ2197222
P1476titleThe conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death
P478volume6

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cites work (P2860)
Q36532821A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems.
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Q28080723TrxR1 as a potent regulator of the Nrf2-Keap1 response system

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