Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists

scientific journal article

Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0123-06.2005
P3181OpenCitations bibliographic resource ID4485347
P932PMC publication ID6673968
P698PubMed publication ID16540562

P2093author name stringMark L Mayer
David E Jane
Alokesh Ghosal
Nigel P Dolman
P2860cites workCrystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding coreQ27628494
Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo stateQ27634328
Mechanism of glutamate receptor desensitizationQ27639007
Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualateQ27640247
Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQXQ27640289
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changesQ27641132
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding coreQ27641433
Structural basis for partial agonist action at ionotropic glutamate receptorsQ27641700
Use of TLS parameters to model anisotropic displacements in macromolecular refinementQ27860499
Raster3D: photorealistic molecular graphicsQ27860557
An extensively modified version of MolScript that includes greatly enhanced coloring capabilitiesQ27860594
Likelihood-enhanced fast translation functionsQ27860634
Automated MAD and MIR structure solutionQ27861114
The glutamate receptor ion channelsQ28137916
Functional characterization of a potassium-selective prokaryotic glutamate receptorQ28141582
Mechanism of positive allosteric modulators acting on AMPA receptorsQ28274582
Subunit composition of kainate receptors in hippocampal interneuronsQ28594070
Electron-density map interpretationQ29620698
Protein flexibility using constraints from molecular dynamics simulations.Q30351794
A molecular viewer for the analysis of TLS rigid-body motion in macromoleculesQ33213690
Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acidQ33819900
Ligands for glutamate receptors: design and therapeutic prospectsQ33967605
Mechanism of partial agonist action at the NR1 subunit of NMDA receptorsQ33988352
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonistQ34323297
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivityQ34396006
Glutamate receptor ion channelsQ34421735
Subunit arrangement and function in NMDA receptorsQ34466595
The tetrameric structure of a glutamate receptor channelQ34470732
Structure and function of glutamate receptor ion channelsQ35672501
Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.Q40348596
Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themesQ41155029
Structural mobility of the extracellular ligand-binding core of an ionotropic glutamate receptor. Analysis of NMR relaxation dynamicsQ44098954
Structural Model of the N-Methyl-D-aspartate Receptor Glycine Site Probed by Site-directed Chemical CouplingQ44405172
Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2alpha,3beta,4beta)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling studyQ44668667
Regulation of AMPA receptor gating by ligand binding core dimersQ44758001
Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligandsQ44762506
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamateQ45264602
Microsecond-to-millisecond conformational dynamics demarcate the GluR2 glutamate receptor bound to agonists glutamate, quisqualate, and AMPA.Q45286924
Binding site flexibility: molecular simulation of partial and full agonists within a glutamate receptor.Q46748258
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.Q51768833
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcrystal structureQ895901
ligand bindingQ61659151
P304page(s)2852-2861
P577publication date2006-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleCrystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists
P478volume26

Reverse relations

cites work (P2860)
Q90244368A kainate receptor-selective RNA aptamer
Q27652127ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function
Q39795927AMPA receptor ligand binding domain mobility revealed by functional cross linking.
Q27662421Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists
Q34108569Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant
Q58707364Chemoreceptor proteins in the Caribbean spiny lobster, Panulirus argus: Expression of Ionotropic Receptors, Gustatory Receptors, and TRP channels in two chemosensory organs and brain
Q30455870Cochlear kainate receptors
Q27679791Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics
Q34947812Conformational changes at the agonist binding domain of the N-methyl-D-aspartic acid receptor
Q40206387Conformational restriction blocks glutamate receptor desensitization
Q36015364Discovery of a new class of ionotropic glutamate receptor antagonists by the rational design of (2S,3R)-3-(3-carboxyphenyl)-pyrrolidine-2-carboxylic acid
Q46702791Distinct receptors underlie glutamatergic signalling in inspiratory rhythm-generating networks and motor output pathways in neonatal rat.
Q33929532Domain organization and function in GluK2 subtype kainate receptors.
Q35731584Emerging structural insights into the function of ionotropic glutamate receptors
Q39953003Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors
Q33876322Exploring kainate receptor pharmacology using molecular dynamics simulations.
Q27654204Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine
Q30391523GIRAF: a method for fast search and flexible alignment of ligand binding interfaces in proteins at atomic resolution
Q37553141GLUK1 receptor antagonists and hippocampal mossy fiber function
Q30538804Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain
Q28290774Glutamate receptor ion channels: structure, regulation, and function
Q40340618Glutamate receptors at atomic resolution
Q33410173Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors
Q41612066Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors
Q42427113Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.
Q35564745High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays.
Q41879732In silico insights of L-glutamate: structural features in vacuum and in complex with its receptor
Q40253441Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate.
Q27667580Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors
Q39956907Luminescence resonance energy transfer investigation of conformational changes in the ligand binding domain of a kainate receptor
Q41452263Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.
Q27654089Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain
Q35865050Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor.
Q27650810Molecular Basis of Kainate Receptor Modulation by Sodium
Q33817617Molecular characterization of the Aphis gossypii olfactory receptor gene families
Q24683346Molecular targets for antiepileptic drug development
Q45398530Novel Functional Properties of Drosophila CNS Glutamate Receptors.
Q28828824Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
Q27646152Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid
Q33618482Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine.
Q35715070Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors
Q24611731Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors
Q27677835Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate Receptors
Q27681450Structural Insights into Competitive Antagonism in NMDA Receptors
Q27677999Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors
Q30593263Structural mechanism of glutamate receptor activation and desensitization
Q27652871Structure of the S1S2 glutamate binding domain of GLuR3
Q35551505Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP.
Q36528592The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain
Q31113565The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data
Q29616617Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila
Q39834944Vibrational spectroscopic investigation of the ligand binding domain of kainate receptors

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