Mechanism of glutamate receptor desensitization

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Mechanism of glutamate receptor desensitization is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1047537581
P356DOI10.1038/417245A
P3181OpenCitations bibliographic resource ID3809568
P698PubMed publication ID12015593
P5875ResearchGate publication ID11355299

P50authorEric GouauxQ28050907
P2093author name stringYu Sun
Neali Armstrong
Rich Olson
Mark Mayer
Michelle Horning
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Rapid desensitization of glutamate receptors in vertebrate central neuronsQ33568172
Partial agonists and G protein-coupled receptor desensitizationQ33677059
Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptorsQ33839007
Structural symmetry and protein functionQ34001342
Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.Q34097927
Structural conservation of ion conduction pathways in K channels and glutamate receptorsQ34271863
The tetrameric structure of a glutamate receptor channelQ34470732
Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesisQ36412306
Molecular dissection of the agonist binding site of an AMPA receptor.Q38287925
Unraveling the modular design of glutamate-gated ion channelsQ40401475
Intersubunit cooperativity in the NMDA receptorQ40761115
Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactionsQ40787121
A point mutation in the glutamate binding site blocks desensitization of AMPA receptorsQ40996183
AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.Q41157007
The impact of receptor desensitization on fast synaptic transmissionQ41367149
Domain interactions regulating ampa receptor desensitization.Q43540452
Cyclothiazide decreases [3H]AMPA binding to rat brain membranes: evidence that AMPA receptor desensitization increases agonist affinity.Q45938224
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteinsQ46739659
Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate.Q48245939
Excitatory amino acid receptors in hippocampal neurons: kainate fails to desensitize them.Q48384656
Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices.Q48402561
Evidence for a tetrameric structure of recombinant NMDA receptors.Q48487196
Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells.Q48706496
Structural determinants of allosteric regulation in alternatively spliced AMPA receptors.Q49058657
Oligomerization and ligand-binding properties of the ectodomain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit GluRD.Q52573377
Agonist-induced isomerization in a glutamate receptor ligand-binding domain. A kinetic and mutagenetic analysis.Q53914526
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A study of the desensitization produced by acetylcholine at the motor end-plateQ74613077
P433issue6886
P407language of work or nameEnglishQ1860
P921main subjectdesensitizationQ2700499
P304page(s)245-53
P577publication date2002-05-16
P1433published inNatureQ180445
P1476titleMechanism of glutamate receptor desensitization
P478volume417

Reverse relations

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Q34006581Role of dimer interface in activation and desensitization in AMPA receptors
Q35430526Role of principal ionotropic and metabotropic receptors in visceral pain
Q37625512Role of stoichiometry in the dimer-stabilizing effect of AMPA receptor allosteric modulators.
Q40444250Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor.
Q34304656SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans
Q34049448Selective expression of heteromeric AMPA receptors driven by flip-flop differences
Q35841037Short-term synaptic plasticity: a comparison of two synapses
Q27008299Size matters in activation/inhibition of ligand-gated ion channels
Q45296396Some assembly required
Q35514668Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating
Q27654538Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization
Q47938743Stabilization of protein-protein interactions in drug discovery
Q36436497Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits
Q34772493Stargazin controls the pharmacology of AMPA receptor potentiators
Q34625854Stargazin interaction with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors is critically dependent on the amino acid at the narrow constriction of the ion channel.
Q42482487Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms.
Q29144870Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors
Q35042155Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.
Q41598077Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
Q27681450Structural Insights into Competitive Antagonism in NMDA Receptors
Q48180487Structural Mechanisms of Gating in Ionotropic Glutamate Receptors.
Q27685440Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Q27667701Structural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and Deactivation
Q27649689Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating
Q27639595Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core
Q27641700Structural basis for partial agonist action at ionotropic glutamate receptors
Q45179957Structural consequences of D481N/K483Q mutation at glycine binding site of NMDA ionotropic glutamate receptors: a molecular dynamics study
Q33922976Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2.
Q38858502Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.
Q37086646Structural rearrangement of the intracellular domains during AMPA receptor activation
Q37184815Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition.
Q45250189Structure and different conformational states of native AMPA receptor complexes
Q34679225Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states
Q35596486Structure and function of AMPA receptors
Q37959399Structure and function of glutamate receptor amino terminal domains
Q38306571Structure and gating of tetrameric glutamate receptors
Q37846960Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation
Q30750616Structure and organization of heteromeric AMPA-type glutamate receptors
Q35247269Structure of an agonist-bound ionotropic glutamate receptor
Q27652871Structure of the S1S2 glutamate binding domain of GLuR3
Q33819900Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid
Q26800669Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains
Q90425146Structure, function, and allosteric modulation of NMDA receptors
Q44591031Structure-Based Rational Design of Chemical Ligands for AMPA-Subtype Glutamate Receptors
Q80459744Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors
Q40604103Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits.
Q34466595Subunit arrangement and function in NMDA receptors
Q33832632Subunit arrangement in N-methyl-D-aspartate (NMDA) receptors
Q27666955Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers
Q35971484Subunit-selective allosteric inhibition of glycine binding to NMDA receptors
Q24307479Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors
Q42792586Synaptic mechanism for the sustained activation of oculomotor integrator circuits in the rat prepositus hypoglossi nucleus: contribution of Ca2+-permeable AMPA receptors
Q37974718Synaptic neurotransmitter-gated receptors
Q28578675TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating
Q24673639Targeting AMPA receptor gating processes with allosteric modulators and mutations
Q33698262Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy
Q47900203The Challenge of Interpreting Glutamate-Receptor Ion-Channel Structures
Q39999426The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization
Q34288139The NMDA receptor as a target for cognitive enhancement
Q41456095The Transmembrane Domain C of AMPA Receptors is Critically Involved in Receptor Function and Modulation
Q45268482The binding site for allosteric modulators of AMPA receptor.
Q34351420The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors
Q78467615The dance of the clams: twists and turns in the family C GPCR homodimer
Q43849872The delta subfamily of glutamate receptors: characterization of receptor chimeras and mutants.
Q39977073The desensitization gate of inhibitory Cys-loop receptors.
Q87892073The dual-gate model for pentameric ligand-gated ion channels activation and desensitization
Q52884291The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions.
Q28473837The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation
Q35058291The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits
Q44230538The expression of dominant-negative subunits selectively suppresses neuronal AMPA and kainate receptors
Q36528592The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain
Q37238823The glutamate receptor subunit delta2 is capable of gating its intrinsic ion channel as revealed by ligand binding domain transplantation
Q34988314The molecular organization of cerebellar long-term depression
Q38218392The multifaceted subunit interfaces of ionotropic glutamate receptors
Q31113565The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data
Q44757997The outer pore of the glutamate receptor channel has 2-fold rotational symmetry
Q33996186The relationship between agonist potency and AMPA receptor kinetics
Q36885427The sequence of events that underlie quantal transmission at central glutamatergic synapses
Q38821887The structure and function of glutamate receptors: Mg2+ block to X-ray diffraction
Q36025437The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution
Q40099264The transmembrane AMPA receptor regulatory protein gamma 4 is a more effective modulator of AMPA receptor function than stargazin (gamma 2).
Q22337264The voltage-gated potassium channels and their relatives
Q27683881Thermodynamics and Mechanism of the Interaction of Willardiine Partial Agonists with a Glutamate Receptor: Implications for Drug Development
Q27673244Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
Q41626318Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins
Q41958491Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators
Q24301398Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes
Q27641132Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes
Q45259186Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly
Q33459415Underestimated Halogen Bonds Forming with Protein Backbone in Protein Data Bank
Q47869150Unitary Properties of AMPA Receptors with Reduced Desensitization
Q59137918Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
Q39834944Vibrational spectroscopic investigation of the ligand binding domain of kainate receptors
Q41966246Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging
Q27658372X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Q34679478X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism
Q27675042Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface
Q30163957pH-dependent dimerization of the carboxyl terminal domain of Cx43.

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