scholarly article | Q13442814 |
P6179 | Dimensions Publication ID | 1047537581 |
P356 | DOI | 10.1038/417245A |
P3181 | OpenCitations bibliographic resource ID | 3809568 |
P698 | PubMed publication ID | 12015593 |
P5875 | ResearchGate publication ID | 11355299 |
P50 | author | Eric Gouaux | Q28050907 |
P2093 | author name string | Yu Sun | |
Neali Armstrong | |||
Rich Olson | |||
Mark Mayer | |||
Michelle Horning | |||
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A study of the desensitization produced by acetylcholine at the motor end-plate | Q74613077 | ||
P433 | issue | 6886 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | desensitization | Q2700499 |
P304 | page(s) | 245-53 | |
P577 | publication date | 2002-05-16 | |
P1433 | published in | Nature | Q180445 |
P1476 | title | Mechanism of glutamate receptor desensitization | |
P478 | volume | 417 |
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Q27651830 | 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor † |
Q48095397 | 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency |
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Q27679486 | A Conformational Intermediate in Glutamate Receptor Activation |
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Q46652676 | A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study |
Q33675838 | A charge-inverting mutation in the "linker" region of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors alters agonist binding and gating kinetics independently of allosteric modulators. |
Q37069448 | A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents |
Q40055046 | A domain linking the AMPA receptor agonist binding site to the ion pore controls gating and causes lurcher properties when mutated. |
Q41961498 | A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors |
Q43065869 | A nondesensitizing kainate receptor point mutant |
Q33456422 | A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors |
Q44627977 | A prokaryotic glutamate receptor: homology modelling and molecular dynamics simulations of GluR0. |
Q44595351 | A role for extracellular Na+ in the channel gating of native and recombinant kainate receptors. |
Q41191935 | A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors. |
Q40692616 | A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating |
Q34332564 | A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity |
Q58805055 | A structurally derived model of subunit-dependent NMDA receptor function |
Q33579886 | A transmembrane accessory subunit that modulates kainate-type glutamate receptors |
Q29617540 | AMPA Receptor Trafficking at Excitatory Synapses |
Q40435403 | AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. |
Q33927174 | AMPA receptor desensitization mutation results in severe developmental phenotypes and early postnatal lethality |
Q39795927 | AMPA receptor ligand binding domain mobility revealed by functional cross linking. |
Q33204326 | AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins |
Q48733648 | AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. |
Q35054673 | AMPA receptor potentiators: from drug design to cognitive enhancement |
Q35809357 | AMPA receptor regulation mechanisms: future target for safer neuroprotective drugs. |
Q44658564 | AMPA receptor tetramerization is mediated by Q/R editing |
Q38421802 | AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications |
Q36277019 | AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity. |
Q48351235 | Acceleration of AMPA receptor kinetics underlies temperature-dependent changes in synaptic strength at the rat calyx of Held. |
Q47930517 | Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM. |
Q35516107 | Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor |
Q42692564 | Activation of NR1/NR2B NMDA receptors. |
Q41904394 | Added astroglia promote greater synapse density and higher activity in neuronal networks |
Q39130774 | Advancing NMDA Receptor Physiology by Integrating Multiple Approaches |
Q27865226 | Agonist occupancy is essential for forward trafficking of AMPA receptors |
Q35148995 | Agonist-specific gating of NMDA receptors |
Q35121805 | Allosteric activation of plasma membrane receptors—physiological implications and structural origins |
Q37220392 | Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks |
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Q28755960 | An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction |
Q35076666 | An evolutionary and structural perspective on T cell antigen receptor function |
Q39313640 | An updated structural classification of substrate-binding proteins |
Q35931870 | Analysis of high-affinity assembly for AMPA receptor amino-terminal domains |
Q46470744 | Anion Channels of Mitochondria |
Q27676573 | Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels |
Q40597783 | Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors |
Q41139926 | Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM. |
Q92370937 | Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8 |
Q35514700 | Arrangement of subunits in functional NMDA receptors |
Q57291629 | Assembly and Trafficking of Homomeric and Heteromeric Kainate Receptors with Impaired Ligand Binding Sites |
Q33649950 | Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex |
Q38306577 | Assembly of AMPA receptors: mechanisms and regulation |
Q43088571 | Asynchronous movements prior to pore opening in NMDA receptors |
Q60912465 | Auxiliary subunits keep AMPA receptors compact during activation and desensitization |
Q24684535 | Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway |
Q27662421 | Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists |
Q44902321 | Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain. |
Q46237503 | Brain Vacuolation Resulting from Administration of the Type II Ampakine CX717 is an Artifact Related to Molecular Structure and Chemical Reaction with Tissue Fixative Agents |
Q36332821 | C-terminal domains of N-methyl-D-aspartic acid receptor modulate unitary channel conductance and gating |
Q37431983 | C-terminal domains of transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor regulatory proteins not only facilitate trafficking but are major modulators of AMPA receptor function |
Q35185455 | Caffeine-induced Ca2+ oscillations in type I horizontal cells of the carp retina and the contribution of the store-operated Ca2+ entry pathway |
Q24625084 | Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization |
Q33870362 | Challenges for and current status of research into positive modulators of AMPA receptors. |
Q35044650 | Channel gating of NMDA receptors |
Q41597083 | Channel opening and gating mechanism in AMPA-subtype glutamate receptors |
Q34099097 | Characterizing single-channel behavior of GluA3 receptors |
Q42573078 | Characterizing the energetic states of the GluR2 ligand binding domain core-dimer. |
Q44853340 | Chemistry and conformation of the ligand-binding domain of GluR2 subtype of glutamate receptors |
Q40231317 | Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor |
Q48013620 | Configurational Preference of the Glutamate Receptor Ligand Binding Domain Dimers |
Q34947812 | Conformational changes at the agonist binding domain of the N-methyl-D-aspartic acid receptor |
Q40328981 | Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating. |
Q27667015 | Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization |
Q40206387 | Conformational restriction blocks glutamate receptor desensitization |
Q89517720 | Conformational spread and dynamics in allostery of NMDA receptors |
Q34771229 | Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. |
Q36776735 | Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl-D-aspartate receptors |
Q33743691 | Contribution of the global subunit structure and stargazin on the maturation of AMPA receptors |
Q34232103 | Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors |
Q37418445 | Control of NMDA receptor function by the NR2 subunit amino-terminal domain |
Q34310112 | Control of assembly and function of glutamate receptors by the amino-terminal domain. |
Q27653239 | Correlating AMPA Receptor Activation and Cleft Closure across Subunits: Crystal Structures of the GluR4 Ligand-Binding Domain in Complex with Full and Partial Agonists † |
Q27678386 | Correlating efficacy and desensitization with GluK2 ligand-binding domain movements |
Q36089680 | Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors |
Q46732075 | CrossTalk proposal: TARPs modulate AMPA receptor gating transitions |
Q39146729 | Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state |
Q41502069 | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation. |
Q92490618 | Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor |
Q27665081 | Crystal Structures of the Glutamate Receptor Ion Channel GluK3 and GluK5 Amino-Terminal Domains |
Q27640265 | Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis |
Q27666247 | Crystal structure of the glutamate receptor GluA1 N-terminal domain |
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Q48445455 | Cyclothiazide prolongs low [Mg2+]-induced seizure-like events. |
Q46638358 | Cyclothiazide: a subunit-specific inhibitor of GABAC receptors |
Q30331574 | Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation. |
Q28710353 | Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function |
Q42382298 | Defining the structural relationship between kainate-receptor deactivation and desensitization |
Q44276064 | Dependence of purinergic P2X receptor activity on ectodomain structure |
Q94047158 | Desensitizing interactions |
Q44557623 | Different gating mechanisms in glutamate receptor and K+ channels. |
Q46580501 | Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. |
Q24808733 | Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila |
Q36761408 | Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes |
Q35610599 | Distinct functional roles of subunits within the heteromeric kainate receptor |
Q44495437 | Distinguishing between presynaptic and postsynaptic mechanisms of short-term depression during action potential trains. |
Q37417929 | Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold |
Q44944785 | Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors |
Q30411551 | Domain architecture of a calcium-permeable AMPA receptor in a ligand-free conformation. |
Q33929532 | Domain organization and function in GluK2 subtype kainate receptors. |
Q58730713 | Drug treatment efficiency depends on the initial state of activation in nonlinear pathways |
Q90353407 | Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain |
Q41373448 | Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation |
Q37189616 | Dynamics of cleft closure of the GluA2 ligand-binding domain in the presence of full and partial agonists revealed by hydrogen-deuterium exchange. |
Q38742202 | Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation. |
Q34479700 | Effects of cyclothiazide on GluR1/AMPA receptors |
Q44911140 | Effects of the lurcher mutation on GluR1 desensitization and activation kinetics. |
Q27865190 | Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family. |
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Q44432169 | Ethanol Inhibits α-Amino-3-hydyroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Function in Central Nervous System Neurons by Stabilizing Desensitization |
Q37247175 | Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations. |
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Q27681406 | Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy |
Q41784821 | Functional insight into development of positive allosteric modulators of AMPA receptors. |
Q26994781 | Functional insights from glutamate receptor ion channel structures |
Q28572778 | Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors |
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Q39928822 | Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum. |
Q46681373 | Gating reaction mechanisms for NMDA receptor channels. |
Q27640749 | Gating the selectivity filter in ClC chloride channels |
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Q48593372 | GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation. |
Q30538804 | Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain |
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Q83525983 | Glutamate receptor ion channels: where do all the calories go? |
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Q36473601 | Glutamate receptors and endoplasmic reticulum quality control: looking beneath the surface |
Q33681057 | Glutamate receptors as seen by light: spectroscopic studies of structure-function relationships |
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Q34952819 | Glutamate receptors: desensitizing dimers |
Q56506255 | Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert |
Q44893087 | Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia |
Q24318579 | Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins |
Q90197080 | Homomeric GluA2(R) AMPA receptors can conduct when desensitized |
Q40671881 | How AMPA receptor desensitization depends on receptor occupancy. |
Q33194893 | How fast does the GluR1Qflip channel open? |
Q79862714 | How to gate an ion channel: lessons from MthK |
Q33744452 | Hydrophobic side chain dynamics of a glutamate receptor ligand binding domain |
Q34820857 | Identification of novel modulators for ionotropic glutamate receptor, iGluA2 by in-silico screening |
Q39777428 | Identification of residues contributing to the ATP binding site of Kir6.2. |
Q40581993 | Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage |
Q92900867 | Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives |
Q35562796 | Interaction of the M4 segment with other transmembrane segments is required for surface expression of mammalian α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors |
Q44560496 | Interdomain dynamics and ligand binding: molecular dynamics simulations of glutamine binding protein. |
Q40226750 | Interface interactions modulating desensitization of the kainate-selective ionotropic glutamate receptor subunit GluR6. |
Q43996873 | Ion channels: how to be desensitized |
Q37613298 | Ion-dependent gating of kainate receptors |
Q36054635 | Ionotropic and metabotropic glutamate receptor structure and pharmacology |
Q35925883 | Ionotropic glutamate receptor recognition and activation |
Q40661443 | Is the isolated ligand binding domain a good model of the domain in the native receptor? |
Q53591450 | Isoform-specific early trafficking of AMPA receptor flip and flop variants. |
Q40699149 | Kainate-binding proteins are rendered functional ion channels upon transplantation of two short pore-flanking domains from a kainate receptor |
Q37337383 | Kinetic basis of partial agonism at NMDA receptors |
Q36283777 | Kinetic contributions to gating by interactions unique to N-methyl-D-aspartate (NMDA) receptors. |
Q37072715 | LRET investigations of conformational changes in the ligand binding domain of a functional AMPA receptor |
Q40483892 | Ligand binding is a critical requirement for plasma membrane expression of heteromeric kainate receptors |
Q48345558 | Long-term potentiation in the juvenile superior colliculus requires simultaneous activation of NMDA receptors and L-type Ca2+ channels and reflects addition of newly functional synapses. |
Q39956907 | Luminescence resonance energy transfer investigation of conformational changes in the ligand binding domain of a kainate receptor |
Q58599990 | Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET |
Q39856314 | Mapping the interaction sites between AMPA receptors and TARPs reveals a role for the receptor N-terminal domain in channel gating |
Q27671791 | Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS |
Q30774134 | Mechanism of NMDA Receptor Inhibition and Activation |
Q39858588 | Mechanism of differential control of NMDA receptor activity by NR2 subunits |
Q37374194 | Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution |
Q41829528 | Mechanism of partial agonism in AMPA-type glutamate receptors |
Q28274582 | Mechanism of positive allosteric modulators acting on AMPA receptors |
Q42934708 | Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors |
Q27654089 | Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain |
Q27641433 | Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core |
Q37811650 | Mechanisms of closed-state inactivation in voltage-gated ion channels |
Q33737261 | Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states |
Q46765841 | Modulation by melatonin of glutamatergic synaptic transmission in the carp retina |
Q38295606 | Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells |
Q92490611 | Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel |
Q37444397 | Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations |
Q46471715 | Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis |
Q45755617 | Modulation of homomeric and heteromeric kainate receptors by the auxiliary subunit Neto1. |
Q33591015 | Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium |
Q36251183 | Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology. |
Q27660095 | Molecular Mechanism of Flop Selectivity and Subsite Recognition for an AMPA Receptor Allosteric Modulator: Structures of GluA2 and GluA3 in Complexes with PEPA |
Q37852112 | Molecular basis of NMDA receptor functional diversity. |
Q38254691 | Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines |
Q40480316 | Molecular determinants responsible for differences in desensitization kinetics of AMPA receptor splice variants. |
Q34123830 | Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3. |
Q39432850 | Molecular level activation insights from a NR2A/NR2B agonist |
Q27652965 | Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 |
Q27651229 | Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors |
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Q64115078 | Multimerization of Homo sapiens TRPA1 ion channel cytoplasmic domains |
Q40611803 | Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors. |
Q41886933 | NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers |
Q90715019 | NMDA receptor channel gating control by the pre-M1 helix |
Q27684638 | NMDA receptor structures reveal subunit arrangement and pore architecture |
Q40373782 | NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists |
Q45970421 | NR2B signaling regulates the development of synaptic AMPA receptor current. |
Q47911476 | Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics. |
Q35174855 | Not all desensitizations are created equal: physiological evidence that AMPA receptor desensitization differs for kainate and glutamate |
Q45398530 | Novel Functional Properties of Drosophila CNS Glutamate Receptors. |
Q48521954 | Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077. |
Q36074474 | Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeability. |
Q27646152 | Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid |
Q41491434 | Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors |
Q33659760 | Pharmacological enhancement of memory or cognition in normal subjects |
Q36394958 | Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors |
Q90430431 | Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations |
Q24611731 | Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors |
Q49982459 | Positive and Negative Allosteric Modulators of N-Methyl-D-Aspartate (NMDA) Receptors; Structure-Activity Relationships and Mechanisms of Action. |
Q44697358 | Prediction of allosteric sites on protein surfaces with an elastic-network-model-based thermodynamic method |
Q47100457 | Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains |
Q36438318 | Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors |
Q27656975 | Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives |
Q44872432 | Properties of quantal transmission at CA1 synapses |
Q36713681 | Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation. |
Q42739559 | Quantifying water-mediated protein-ligand interactions in a glutamate receptor: a DFT study |
Q42652956 | R/G editing in GluA2Rflop modulates the functional difference between GluA1 flip and flop variants in GluA1/2R heteromeric channels |
Q33286497 | Receptor occupancy and channel-opening kinetics: a study of GLUR1 L497Y AMPA receptor |
Q34771224 | Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins. |
Q37178076 | Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits. |
Q44758001 | Regulation of AMPA receptor gating by ligand binding core dimers |
Q79349337 | Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry |
Q38306583 | Retour aux sources: defining the structural basis of glutamate receptor activation |
Q46656413 | Role of AMPA receptor desensitization and the side effects of a DMSO vehicle on reticulospinal EPSPs and locomotor activity |
Q34006581 | Role of dimer interface in activation and desensitization in AMPA receptors |
Q35430526 | Role of principal ionotropic and metabotropic receptors in visceral pain |
Q37625512 | Role of stoichiometry in the dimer-stabilizing effect of AMPA receptor allosteric modulators. |
Q40444250 | Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor. |
Q34304656 | SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans |
Q34049448 | Selective expression of heteromeric AMPA receptors driven by flip-flop differences |
Q35841037 | Short-term synaptic plasticity: a comparison of two synapses |
Q27008299 | Size matters in activation/inhibition of ligand-gated ion channels |
Q45296396 | Some assembly required |
Q35514668 | Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating |
Q27654538 | Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization |
Q47938743 | Stabilization of protein-protein interactions in drug discovery |
Q36436497 | Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits |
Q34772493 | Stargazin controls the pharmacology of AMPA receptor potentiators |
Q34625854 | Stargazin interaction with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors is critically dependent on the amino acid at the narrow constriction of the ion channel. |
Q42482487 | Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms. |
Q29144870 | Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors |
Q35042155 | Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors. |
Q41598077 | Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes |
Q27681450 | Structural Insights into Competitive Antagonism in NMDA Receptors |
Q48180487 | Structural Mechanisms of Gating in Ionotropic Glutamate Receptors. |
Q27685440 | Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain |
Q27667701 | Structural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and Deactivation |
Q27649689 | Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating |
Q27639595 | Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core |
Q27641700 | Structural basis for partial agonist action at ionotropic glutamate receptors |
Q45179957 | Structural consequences of D481N/K483Q mutation at glycine binding site of NMDA ionotropic glutamate receptors: a molecular dynamics study |
Q33922976 | Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2. |
Q38858502 | Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels. |
Q37086646 | Structural rearrangement of the intracellular domains during AMPA receptor activation |
Q37184815 | Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition. |
Q45250189 | Structure and different conformational states of native AMPA receptor complexes |
Q34679225 | Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states |
Q35596486 | Structure and function of AMPA receptors |
Q37959399 | Structure and function of glutamate receptor amino terminal domains |
Q38306571 | Structure and gating of tetrameric glutamate receptors |
Q37846960 | Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation |
Q30750616 | Structure and organization of heteromeric AMPA-type glutamate receptors |
Q35247269 | Structure of an agonist-bound ionotropic glutamate receptor |
Q27652871 | Structure of the S1S2 glutamate binding domain of GLuR3 |
Q33819900 | Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid |
Q26800669 | Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains |
Q90425146 | Structure, function, and allosteric modulation of NMDA receptors |
Q44591031 | Structure-Based Rational Design of Chemical Ligands for AMPA-Subtype Glutamate Receptors |
Q80459744 | Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors |
Q40604103 | Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits. |
Q34466595 | Subunit arrangement and function in NMDA receptors |
Q33832632 | Subunit arrangement in N-methyl-D-aspartate (NMDA) receptors |
Q27666955 | Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers |
Q35971484 | Subunit-selective allosteric inhibition of glycine binding to NMDA receptors |
Q24307479 | Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors |
Q42792586 | Synaptic mechanism for the sustained activation of oculomotor integrator circuits in the rat prepositus hypoglossi nucleus: contribution of Ca2+-permeable AMPA receptors |
Q37974718 | Synaptic neurotransmitter-gated receptors |
Q28578675 | TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating |
Q24673639 | Targeting AMPA receptor gating processes with allosteric modulators and mutations |
Q33698262 | Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy |
Q47900203 | The Challenge of Interpreting Glutamate-Receptor Ion-Channel Structures |
Q39999426 | The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization |
Q34288139 | The NMDA receptor as a target for cognitive enhancement |
Q41456095 | The Transmembrane Domain C of AMPA Receptors is Critically Involved in Receptor Function and Modulation |
Q45268482 | The binding site for allosteric modulators of AMPA receptor. |
Q34351420 | The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors |
Q78467615 | The dance of the clams: twists and turns in the family C GPCR homodimer |
Q43849872 | The delta subfamily of glutamate receptors: characterization of receptor chimeras and mutants. |
Q39977073 | The desensitization gate of inhibitory Cys-loop receptors. |
Q87892073 | The dual-gate model for pentameric ligand-gated ion channels activation and desensitization |
Q52884291 | The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions. |
Q28473837 | The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation |
Q35058291 | The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits |
Q44230538 | The expression of dominant-negative subunits selectively suppresses neuronal AMPA and kainate receptors |
Q36528592 | The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain |
Q37238823 | The glutamate receptor subunit delta2 is capable of gating its intrinsic ion channel as revealed by ligand binding domain transplantation |
Q34988314 | The molecular organization of cerebellar long-term depression |
Q38218392 | The multifaceted subunit interfaces of ionotropic glutamate receptors |
Q31113565 | The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data |
Q44757997 | The outer pore of the glutamate receptor channel has 2-fold rotational symmetry |
Q33996186 | The relationship between agonist potency and AMPA receptor kinetics |
Q36885427 | The sequence of events that underlie quantal transmission at central glutamatergic synapses |
Q38821887 | The structure and function of glutamate receptors: Mg2+ block to X-ray diffraction |
Q36025437 | The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution |
Q40099264 | The transmembrane AMPA receptor regulatory protein gamma 4 is a more effective modulator of AMPA receptor function than stargazin (gamma 2). |
Q22337264 | The voltage-gated potassium channels and their relatives |
Q27683881 | Thermodynamics and Mechanism of the Interaction of Willardiine Partial Agonists with a Glutamate Receptor: Implications for Drug Development |
Q27673244 | Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2 |
Q41626318 | Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins |
Q41958491 | Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators |
Q24301398 | Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes |
Q27641132 | Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes |
Q45259186 | Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly |
Q33459415 | Underestimated Halogen Bonds Forming with Protein Backbone in Protein Data Bank |
Q47869150 | Unitary Properties of AMPA Receptors with Reduced Desensitization |
Q59137918 | Unmasking GluN1/GluN3A excitatory glycine NMDA receptors |
Q39834944 | Vibrational spectroscopic investigation of the ligand binding domain of kainate receptors |
Q41966246 | Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging |
Q27658372 | X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor |
Q34679478 | X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism |
Q27675042 | Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface |
Q30163957 | pH-dependent dimerization of the carboxyl terminal domain of Cx43. |
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