A study of the desensitization produced by acetylcholine at the motor end-plate

scientific article published on 01 August 1957

A study of the desensitization produced by acetylcholine at the motor end-plate is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.1957.SP005838
P932PMC publication ID1363030
P698PubMed publication ID13463799

P2093author name stringB KATZ
S THESLEFF
P2860cites workQuantal components of the end-plate potentialQ24538708
A modification of receptor theoryQ24553119
The ultrastructure of a reptilian myoneural junctionQ36437005
The interaction between edrophonium (tensilon) and acetylcholine at the motor end-plateQ42215475
Interaction at End-Plate Receptors between Different Choline DerivativesQ56555526
A further study of the statistical composition on the end-plate potentialQ73882705
A study of curare action with an electrical micromethodQ74505727
The electromotive action of acetylcholine at the motor end-plateQ75606545
On the localization of acetylcholine receptorsQ78639296
Local activity at a depolarized nerve‐muscle junctionQ78732582
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdesensitizationQ2700499
P304page(s)63-80
P577publication date1957-08-01
P1433published inJournal of PhysiologyQ7743612
P1476titleA study of the desensitization produced by acetylcholine at the motor end-plate
P478volume138

Reverse relations

cites work (P2860)
Q43811013'Concentration-clamp' study of gamma-aminobutyric-acid-induced chloride current kinetics in frog sensory neurones.
Q364200383HPhencyclidine: a probe for the ionic channel of the nicotinic receptor
Q394493805-HT3 receptors in outside-out patches of N1E-115 neuroblastoma cells: basic properties and effects of pentobarbital
Q589705675-Hydroxytryptamine Receptors and Synaptic Transmission in Molluscan Neurones
Q3410994786Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization
Q41179820A Model Based on Receptor Desensitization for Cyclic AMP Signaling in Dictyostelium Cells
Q39994307A cholinoceptor antiserum: its pharmacological properties
Q48174450A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum.
Q42089807A comparison of the action of glutamate, ibotenate and other related amino acids on feline spinal interneurones
Q42716727A comparison of the actions of agonists and antagonists at non-NMDA receptors of C fibres and motoneurones of the immature rat spinal cord in vitro
Q73661239A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological study
Q40014853A comparison of the time course of excitation and inhibition by iontophoretic decamethonium in frog endplate
Q34329164A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site
Q37240626A gating mechanism of pentameric ligand-gated ion channels
Q24795064A homotropic two-state model and auto-antagonism
Q42084783A kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocampal neurones
Q41511516A kinetic model for the action of xylocaine on receptors for acetylcholine
Q42526095A mechanism for exact sensory adaptation based on receptor modification
Q36654301A model of excitation and adaptation in bacterial chemotaxis
Q35598842A molecular mechanism for sensory adaptation based on ligand-induced receptor modification
Q36935264A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium
Q42017488A molecular scheme for the reaction between acetylcholine and nicotinic channels
Q40187382A new myasthenic syndrome with end-plate acetylcholinesterase deficiency, small nerve terminals, and reduced acetylcholine release
Q35100243A physiological mechanism for Hebb's postulate of learning
Q67018275A possible modulation of acetylcholine receptors of embryonic chick muscle cells by α-bungarotoxin
Q52979944A quantitative description of end-plate currents
Q44879718A quantitative description of end-plate currents in the presence of two lidocaine derivatives
Q83066084A self-limiting regulation of vasoconstrictor-activated TRPC3/C6/C7 channels coupled to PI(4,5)P₂-diacylglycerol signalling
Q48644137A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating.
Q73310652A strong constant magnetic field affects muscle tension development in bullfrog neuromuscular preparations
Q72918419A study of desensitization of acetylcholine receptors using nerve-released transmitter in the frog
Q66879477A study of desensitization using voltage clamp
Q78736099A study of supersensitivity in denervated mammalian skeletal muscle
Q36388494A study of the reinnervation of fast and slow mammalian muscles
Q34708055A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
Q44112392A transient state concept of drug receptor interaction
Q71795103Acetylcholine Binding to Torpedo Electroplax: Relationship to Acetylcholine Receptors
Q36118285Acetylcholine at motor nerves: storage, release, and presynaptic modulation by autoreceptors and adrenoceptors
Q72941369Acetylcholine changes underlying transmission of a single nerve impulse in the presence of 4-aminopyridine inTorpedo
Q37564727Acetylcholine receptor (from Electrophorus electricus): a comparison of single-channel current recordings and chemical kinetic measurements
Q34657454Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method
Q36835480Acetylcholine receptor distribution on myotubes in culture correlated to acetylcholine sensitivity
Q36408986Acetylcholine receptor in planar lipid bilayers. Characterization of the channel properties of the purified nicotinic acetylcholine receptor from Torpedo californica reconstituted in planar lipid bilayers
Q70864054Acetylcholine receptor inactivation in Torpedo californica electroplax membrane vesicles. Detection of two processes in the millisecond and second time regions
Q40124099Acetylcholine receptor kinetics
Q39755147Acetylcholine receptor kinetics: chemical kinetics
Q72631988Acetylcholine receptor-controlled ion flux in electroplax membrane vesicles: Identification and characterization of membrane properties that affect ion flux measurements
Q66966177Acetylcholine receptor-controlled ion fluxes in membrane vesicles investigated by fast reaction techniques
Q46822943Acetylcholine receptor: SH group reactivity as indicator of conformational changes and functional states
Q43654935Acetylcholine receptors
Q68631927Acetylcholine receptors in muscle fibres
Q35371712Acetylcholine-induced cation translocation across cell membranes and inactivation of the acetylcholine receptor: chemical kinetic measurements in the millisecond time region
Q46189706Acetylcholine-induced currents in denervated mouse soleus muscle: Effects of antagonists
Q37583148Acetylcholine-receptor-mediated ion flux in electroplax membrane microsacs (vesicles): Change in mechanism produced by asymmetrical distribution of sodium and potassium ions
Q72733063Acetylcholinesterase is functional in embryonic rat muscle before its accumulation at the sites of nerve-muscle contact
Q52525877Acetylcholinesterase mutants in Drosophila and their effects on the structure and function of the central nervous system.
Q35029197Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries
Q48612205Action of nicotine on identified cells of the snail brain.
Q36069197Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids
Q36412485Activation and Desensitization of the Recombinant P2X1 Receptor at Nanomolar ATP Concentrations
Q67523249Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones
Q36319861Activation and desensitization of Torpedo acetylcholine receptor: evidence for separate binding sites
Q70154442Activation and desensitization of acetylcholine receptors in fish muscle with a photoisomerizable agonist
Q34481851Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists
Q71693522Activation of acetylcholine receptors causes the partition of hydrophobic cations into postsynaptic membrane vesicles
Q42638916Activation of ion channels in the frog end-plate by high concentrations of acetylcholine
Q36318058Activation of skeletal muscle nicotinic acetylcholine receptors
Q36365367Activation, inactivation, and desensitization of acetylcholine receptor channel complex detected by binding of perhydrohistrionicotoxin
Q40662918Activities of 5-methylfurfuryltrimethylammonium iodide (5-methylfurmethide) at nicotinic receptors
Q42261927Activity of analogues of decamethonium on the chick biventer cervicis preparation
Q37383662Acute alcohol action and desensitization of ligand-gated ion channels
Q68020192Acute tolerance to the locomotor stimulant effects of nicotine in the rat
Q72235791Adaptation of the neuromuscular junction to constant concentration of ACh
Q52553420Adaptation, oscillations and relay in a model for cAMP secretion in cellular slime molds.
Q39266918Adaptive Alterations in Receptor Mediated Processes and their Implications for Some Mental Disorders
Q45390145Adenosine A2A receptor induces protein kinase A-dependent functional modulation of human (alpha)3(beta)4 nicotinic receptor
Q41841380Affinity change of the adipocyte receptor fails to alter insulin-stimulated glucose transport
Q38275036Agonist activation of a nicotinic acetylcholine receptor
Q40586327Agonist-dependence of recovery from desensitization of P2X(3) receptors provides a novel and sensitive approach for their rapid up or downregulation
Q67007405Agonist-induced affinity alterations of a central nervous system alpha-bungarotoxin receptor
Q36190588Agonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains
Q66966144Agonist-induced potentiation of acetylcholine sensitivity in denervated skeletal muscle
Q31877576Agonist-stimulated internalisation of the ligand-gated ion channel P2X(1) in rat vas deferens
Q34139176Allosteric binding sites on cell-surface receptors: novel targets for drug discovery
Q41298406Allosteric proteins after thirty years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors
Q77694440Allosteric receptors after 30 years
Q35493550Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective
Q34539431Allosteric transition: a comparison of two models
Q48007244Allosteric transitions of the acetylcholine receptor.
Q48957168Alpha-bungarotoxin-sensitive nicotinic responses in rat tuberomammillary neurons.
Q28366913Alteration of smooth muscle contractility after muscarinic agonist-induced K+ loss
Q39230947Amino Acids as Neurotransmitters
Q92921229Amplification of Snake Venom Toxicity by Endogenous Signaling Pathways
Q42578369An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors
Q52251008An algorithmic method for determining the kinetic system of receptor-channel complexes.
Q28298684An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics
Q46760126An analysis of the depolarization produced in guinea-pig hippocampus by cholinergic receptor stimulation
Q67427898An analysis of the dose-response curve at voltage-clamped frog-endplates
Q42633579An electrophysiological analysis of the effects of noradrenaline and alpha-receptor antagonists on neuromuscular transmission in mammalian muscular arteries
Q41525987An electrophysiological study of 5-hydroxytryptamine receptors of neurones in the molluscan nervous system
Q63978131An electrophysiological study of chelonian skeletal muscle
Q38039375An outline of desensitization in pentameric ligand-gated ion channel receptors.
Q48648746Analysis of Mauthner cell responses to iontophoretically delivered pulses of GABA, glycine and L-glutamate.
Q40097292Analysis of a model for transmitter kinetics
Q40654524Analysis of atropine action at the frog neutromuscular junction
Q66922623Analysis of ergotamine — 5-HT interaction on the isolated rat stomach preparation
Q37638539Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus
Q35566473Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain
Q68487707Antinicotine action of nicotine and lobeline on frog sartorius muscle
Q52854652Apparent cooperative effects in acetylcholine receptor-mediated ion flux in electroplax membrane preparations
Q46838520Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization
Q40080823Aspartate and other inhibitors of excitatory synaptic transmission in crayfish muscle
Q36185892Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats
Q67275093Augmentation of acetylcholine response in denervated skeletal muscle by endorphins and spinal cord-conditioned culture media
Q37484745Autoinhibition of acetylcholine binding to Torpedo electroplax; a possible molecular mechanism for desensitization
Q52675861Autonomous chaotic behaviour of the slime mould Dictyostelium discoideum predicted by a model for cyclic AMP signalling.
Q51391361Binding properties of agonists and antagonists to distinct allosteric states of the nicotinic acetylcholine receptor are incompatible with a concerted model.
Q39777230Biochemical analysis of cholinergic mechanisms in skeletal muscle
Q39717065Biochemical investigations of ionic channels in excitable membranes
Q68532525Blockade by lobeline of potassium exchange in skeletal muscle. Relationship to receptor desensitization at the endplate
Q40042716Blockade of desensitization of nicotinic receptors of the cat adrenal medulla by concanavalin A
Q36031349Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac)
Q41366678Botulinum toxin prevents stimulus-induced backfiring produced by neostigmine in the mouse phrenic nerve-diaphragm
Q34253279Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states
Q47679208Ca2+ influx through voltage-gated Ca2+ channels regulates 5-HT3 receptor channel desensitization in rat glioma x mouse neuroblastoma hybrid NG108-15 cells
Q54398555Caesium ions activate chloride channels in rat cultured spinal cord neurones.
Q42632411Calcium channel effectors are potent non-competitive blockers of acetylcholine receptors
Q36434281Calcium currents in bullfrog sympathetic neurons. II. Inactivation
Q43521831Calcium dependence of acetylcholine induced conductance changes
Q41539324Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release
Q39153034Calcium-Dependent Depression of a Late Outward Current in Snail Neurons
Q41759470Calcium-dependent desensitizing function of the postsynaptic neuronal-type nicotinic acetylcholine receptors at the neuromuscular junction
Q54113248Calcium-dependent, slow desensitization distinguishes different types of glutamate receptors.
Q72774600Calcium-mediated modulation of N-methyl-D-aspartate (NMDA) responses in cultured rat hippocampal neurones
Q43743096Calibration of agonist concentrations applied by pressure pulses or via rapid solution exchanger
Q42976988Cd2+ regulation of the hyperpolarization-activated current IAB in crayfish muscle
Q37247103Cellular events in nicotine addiction
Q54681436Changes in the sensitivity to cholinomimetic drugs of smooth and cardiac muscle in the rat induced by subacute administration of di-isopropyl phosphorofluoridate
Q36496886Channel gating kinetics and synaptic efficacy: a hypothesis for expression of long-term potentiation
Q34536117Channel properties of the purified acetylcholine receptor from Torpedo californica reconstituted in planar lipid bilayer membranes
Q37116097Characteristics and mechanism of neuromuscular block in myasthenia gravis
Q46107031Characteristics and tachyphylaxis of gastrin-stimulated gastric acid secretion in the cat
Q70870578Characterization of the α‐Bungarotoxin Receptor in Chick‐Embryo Retina
Q34374993Chemical kinetic measurements of a mammalian acetylcholine receptor by a fast-reaction technique
Q37259110Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats
Q73134803Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons
Q67013507Cholinergic ligand-induced affinity changes in Torpedo californica acetylcholine receptor
Q38372480Cholinergic modulation of the hippocampal region and memory function
Q40012636Cholinergic receptor desensitization
Q42051934Cholinergic regulation of the corpora allata in adult male loreyi leafworm Mythimna loreyi
Q40821290Chronic exposure to nicotine upregulates the human (alpha)4((beta)2 nicotinic acetylcholine receptor function.
Q43616826Chronic nicotine and locomotor activity: influences of exposure dose and test dose
Q36465049Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism
Q72520450Closure of membrane channels gated by glutamate receptors may be a two-step process
Q40231317Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor
Q33639494Cocaine: mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique
Q30396291Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking
Q40036949Comparative Electrobiology of Excitable Membranes
Q36281259Comparison of acetylcholine receptor-controlled cation flux in membrane vesicles from Torpedo californica and Electrophorus electricus: chemical kinetic measurements in the millisecond region
Q71434387Comparison of cholinergic activation and desensitization at snake twitch and slow muscle fibre end-plates
Q42632213Comparison of desensitization and time-dependent block of the acetylcholine receptor responses by chlorpromazine, cytochalasin B, triton X-100 and other agents
Q42519763Comparison of secretion of catecholamines from the rat adrenal medulla during continuous exposure to nicotine, muscarine or excess K
Q39263003Comparison of the acetylcholine response potentials with the synaptic potentials in molluscan central nerve cells
Q37151606Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytes
Q71794439Competitive interaction of β-guanidino propionic acid and γ-aminobutyric acid on the muscle fibre of the crayfish
Q45161396Concanavalin A blocks desensitisation of glutamate receptors on insect muscle fibres
Q42404119Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC)
Q72084246Congenital myasthenic syndromes
Q81651278Congenital myasthenic syndromes
Q35573367Congenital myasthenic syndromes: multiple molecular targets at the neuromuscular junction.
Q37141170Context-dependent modulation of alphabetagamma and alphabetadelta GABA A receptors by penicillin: implications for phasic and tonic inhibition
Q78937448Contractures and permeability changes produced by acetylcholine in depolarized denervated muscle
Q41645484Cooperative interactions of histamine and competitive antagonism by cimetidine at neuronal histamine receptors in the marine mollusc, Aplysia californica
Q33986877Correlation of polypeptide composition with functional events in acetylcholine receptor-enriched membranes from Torpedo californica
Q49098650Cortical inhibition and γ-aminobutyric acid
Q72885454Coupling between the nicotinic acetylcholine receptor site and the ionic channel site
Q27675116Creating an  7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein: CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSES
Q54708129Crisis, precrisis and drug resistance in myasthenia gravis
Q39146729Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state
Q44252827Current status of research on myasthenia gravis
Q34367462Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons
Q48613961Cytophotometric analyses of thalamic neuronal RNA in soman intoxicated rats
Q43654271Deactivation and desensitization of mouse embryonic- and adult-type nicotinic receptor channel currents
Q67795959Decrease of Na+ conductance during desensitisation of the frog endplate
Q42213613Decreased sensitivity to nicotine-induced seizures as a consequence of nicotine pretreatment in long-sleep and short-sleep mice
Q42382298Defining the structural relationship between kainate-receptor deactivation and desensitization
Q48897756Demonstration of a slowly dissociating form of bovine hippocampal synaptic membrane opiate receptors
Q41522711Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium
Q28769518Dependence of acetylcholine receptor channel kinetics on agonist concentration in cultured mouse muscle fibres
Q39928817Depression and recovery of transmission at the squid giant synapse
Q40652474Desensitisation does not selectively alter sodium channels
Q43076957Desensitization and models of receptor-channel activation
Q40645758Desensitization and recovery at the frog neuromuscular junction
Q42933626Desensitization and resensitization kinetics of glutamate receptor channels from Drosophila larval muscle
Q72106462Desensitization at the frog neuromuscular junction: a biphasic process
Q39856662Desensitization by noradrenaline of responses to stimulation of pre- and postsynaptic adrenoceptors
Q36295887Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor
Q72953563Desensitization in denervated mouse muscles
Q40007365Desensitization in the innervated and in the chronically denervated soleus muscle of the mouse
Q67683953Desensitization is a property of the cholinergic binding region of the nicotinic acetylcholine receptor, not of the receptor-integral ion channel
Q42182878Desensitization mechanism in prokaryotic ligand-gated ion channel
Q40704823Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function.
Q41630120Desensitization of acetylcholine receptors in BC3H-1 cells
Q35107588Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness
Q40728018Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels
Q41744471Desensitization of glutamate receptors on innervated and denervated locust muscle fibres
Q36852265Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
Q73885655Desensitization of mutant acetylcholine receptors in transgenic mice reduces the amplitude of neuromuscular synaptic currents
Q40360827Desensitization of neuronal nicotinic receptors of human neuroblastoma SH-SY5Y cells during short or long exposure to nicotine
Q83386448Desensitization of neurotransmitter-gated ion channels during high-frequency stimulation: a comparative study of Cys-loop, AMPA and purinergic receptors
Q36096529Desensitization of the acetylcholine receptor of denervated rat soleus muscle and the effect of calcium
Q54106728Desensitization of the acetylcholine receptor of frog end-plates measured in a Vaseline-gap voltage clamp.
Q68961100Desensitization of the acetylcholine-induced increase of potassium conductance in rabbit cardiac Purkinje fibres
Q53934015Desensitization of the alpha adrenergic receptor system in guinea pig vas deferens
Q44681087Desensitization of the inhibition of the M-current in sympathetic neurons: Effects of ATP analogs, polyanions, and multiple agonist applications
Q72079978Desensitization of the muscarinic receptor of bullfrog atrial muscle
Q38657377Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators
Q34128667Desensitization of the skeletal muscle ryanodine receptor: evidence for heterogeneity of calcium release channels
Q42975589Desensitization onset and recovery at the potassium-depolarized frog neuromuscular junction are voltage sensitive
Q38173743Desensitization properties of P2X3 receptors shaping pain signaling
Q73653953Desensitization shortens the high-quantal-content endplate current time course in frog muscle with intact cholinesterase
Q71492663Desensitization to acetylcholine of frog tonic muscle fibres
Q41059753Desensitization to gamma-aminobutyric acid in crustacean muscle fibres
Q72550331Desensitization to glutamate does not affect synaptic transmission in rat hippocampal slices
Q40444465Determination of the Chemical Mechanism of Neurotransmitter Receptor‐mediated Reactions by Rapid Chemical Kinetic Methodsa
Q36840229Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods
Q72100619Determination with high resistance micropipettes of acetylcholine sensitivity in frog slow muscle fibres
Q32055083Development and application of caged ligands for neurotransmitter receptors in transient kinetic and neuronal circuit mapping studies
Q54110509Development of desensitization during repetitive end-plate activity and single end-plate currents in frog muscle.
Q42214736Differences in agonist dissociation constant estimates for 5-HT at 5-HT2-receptors: a problem of acute desensitization?
Q59061411Differences in the kinetics of rod and cone synaptic transmission
Q40425965Differential Effect of Chronic Nicotine Treatment on Nicotinic Receptor Numbers in Various Brain Regions of Mice
Q37535489Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions
Q41642985Differential effects of diltiazem on glutamate potentials and excitatory junctional potentials at the crayfish neuromuscular junction
Q40662760Diffusion barrier for acetylcholine at the frog neuromuscular junction
Q37262520Dihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant
Q81015764Diphasic postsynaptic potential: a chemical synapse capable of mediating conjoint excitation and inhibition
Q34125743Direct measurement of the concentration- and time-dependent open probability of the nicotinic acetylcholine receptor channel
Q58197284Dissociation kinetics of the thyrotropin-receptor complex
Q40683187Distribution of acetylcholine receptors at frog neuromuscular junctions with a discussion of some physiological implications
Q41823944Do motor-nerve terminals have gamma-aminobutyric acid receptors?
Q43263076Donepezil modulates nicotinic receptors of substantia nigra dopaminergic neurones
Q54148354Dose-response of acetylcholine receptor channels opened by a flash-activated agonist in voltage-clamped rat myoballs.
Q46266321Down-regulation of A1 adenosine receptors coupled to muscarinic K+ current in cultured guinea-pig atrial myocytes
Q46191050Drug receptors and their function
Q46674986Dual agonist-antagonist effects of 5-hydroxytryptamine (5-HT) in the guinea pig ileum: Evidence for a selective receptor desensitization effect
Q34069620Dynamic mechanisms of non-classical antagonism by competitive AT(1) receptor antagonists
Q35035321Dynamic properties of isolated acetylcholine receptor protein: kinetics of the binding of acetylcholine and Ca ions
Q41737171Effect of adenosine triphosphate on the sensitivity of the nicotinic acetylcholine-receptor in the bullfrog sympathetic ganglion cell
Q39188271Effect of diazepam on the frog neuromuscular junction
Q42213807Effect of nicotine pretreatment on nicotine-induced seizures
Q73650320Effects of a homoanatoxin-a-containing extract from Oscillatoria formosa (Cyanophyceae/cyanobacteria) on neuromuscular transmission
Q46912250Effects of acetylcholine and parasympathetic nerve stimulation on membrane potential in quiescent guinea-pig atria
Q46639621Effects of aniracetam after LTP induction are suggestive of interactions on the kinetics of the AMPA receptor channel
Q42561371Effects of antagonists on quisqualate and nicotinic receptor-mediated currents of midbrain neurones in culture
Q69848794Effects of carbamylcholine on membrane potential and Na-K pump activity of cultured rat skeletal myotubes
Q44111183Effects of clomipramine on neuronal nicotinic acetylcholine receptors.
Q71799971Effects of concanavalin A on desensitization kinetics of GABA responses inAchatina fulica neurons
Q72556695Effects of concanavalin A on glutamate operated postsynaptic channels in crayfish muscle
Q39191278Effects of concanavalin A on junctional and extrajunctional L-glutamate receptors on locust skeletal muscle fibres
Q52444779Effects of dihydroavermectin B1a and analogs on stretcher muscle of the lined shore crab, Pachygrapsus crassipes
Q39192464Effects of dithiothreitol on end-plate currents
Q71759906Effects of local and repeated systemic administration of (-)nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine, and serotonin in rat cortex
Q44826338Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs
Q36963775Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats
Q44753563Effects of small organic molecules on the cholinergic receptors of the motor endplate
Q68221655Effects of temperature and analyte application technique on neuron-based chemical sensing
Q37352047Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice.
Q34742798Efficacy at G-protein-coupled receptors
Q39645377Electrophysiological and Pharmacological Properties of Skeletal Muscle in Culture
Q37601156Electrophysiological and biochemical studies on enhancement of desensitization by phenothiazine neuroleptics
Q71198146Electrophysiological consequences of ligand binding to the desensitized 5-HT3 receptor in mammalian NG108-15 cells
Q41868084Electrophysiological estimation of the actions of acetylcholinesterase inhibitors on acetylcholine receptor and cholinesterase in physically isolated Aplysia neurones
Q34172607Electrostatic interactions regulate desensitization of the nicotinic acetylcholine receptor
Q34522883Emerging structure of the nicotinic acetylcholine receptors
Q24618824End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease
Q41506892End-plate currents and acetylcholine noise at normal and myasthenic human end-plates
Q70223967End-plate currents evoked by paired stimuli in frog muscle fibres
Q34961709Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine.
Q37440597Enhancement by carbachol of transmitter release from motor nerve terminals
Q70431825Evidence for the role of non-quantal acetylcholine in the maintenance of the membrane potential of rat skeletal muscle
Q44911969Evidence of cellular nicotinic receptor desensitization in rats exhibiting nicotine-induced acute tolerance
Q69149819Excitable membrane stabilization by diphenylhydantoin and calcium
Q36913571Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation
Q51203061Excitation and depression of cortical neurones by 5-hydroxytryptamine.
Q79313867Excitation and depression of eccrine sweat glands by acetylcholine, acetyl-beta-methylcholine and adrenaline
Q32160899Excitatory synaptic inputs on myenteric Dogiel type II neurones of the pig ileum
Q76849790FURTHER OBSERVATIONS ON THE DISTRIBUTION OF ACTYLCHOLINE-REACTIVE SITES IN SKELETAL MUSCLE
Q39938312Factors affecting the time course of decay of end-plate currents: a possible cooperative action of acetylcholine on receptors at the frog neuromuscular junction
Q42580304Fading and rebound of currents induced by ATP in PC12 cells
Q24540445Failure of neuromuscular propagation in rats
Q41554371Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane-Bound Acetylcholine Receptor from Torpedo marmorata
Q42153691Fast desensitization of the nicotinic receptor at the mouse neuromuscular junction
Q36304502Fixation of allosteric states of the nicotinic acetylcholine receptor by chemical cross-linking
Q54464041Force and membrane potential in acetylcholine and potassium contractures of denervated mouse muscles.
Q35615745Forskolin increases the rate of acetylcholine receptor desensitization at rat soleus endplates
Q54610046Four types of GABA receptors in crayfish leg muscles characterized by desensitization and specific antagonist
Q43002524Fourth gaddum memorial lecture, school of pharmacy, university of london, january 1973.
Q26750783From kinetics and cellular cooperations to cancer immunotherapies
Q41737182From muscle endplate to brain synapses: a short history of synapses and agonist-activated ion channels
Q40992011Function of the M1 π-helix in endplate receptor activation and desensitization.
Q36391219Functional acetylcholine receptor from Torpedo marmorata in planar membranes
Q40386612Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels
Q41499110Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells
Q40126159Functional reassembly of membrane proteins in planar lipid bilayers
Q48727505G-protein-mediated desensitization of metabotropic glutamatergic and muscarinic responses in CA3 cells in rat hippocampus.
Q47229649GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC50 and Basal Activity
Q70160131GABA as a trophic factor during development
Q48859343GABA ‘desensitization’ of frog primary afferent fibers
Q40515562Genetic and environmental aspects of the role of nicotinic receptors in neurodegenerative disorders: emphasis on Alzheimer's disease and Parkinson's disease
Q40190439Glutamate current noise: post-synaptic channel kinetics investigated under voltage clamp
Q43744019Glutamate sensitivity and distribution of receptors along normal and denervated locust muscle fibres
Q27316064Glycine receptor mechanism elucidated by electron cryo-microscopy
Q68981290Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes
Q34260576High acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo
Q34527541Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor
Q37817262Hormonal regulation of membrane receptors and cell responsiveness: A review
Q68672956Hormone-induced desensitisation of hormonal control of cyclic AMP levels in human diploid fibroblasts
Q33194893How fast does the GluR1Qflip channel open?
Q24320183Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme
Q41742031Human nicotinic acetylcholine receptor: the influence of second messengers on activation and desensitization
Q51863774Hypermagnesaemia and anaesthetic management.
Q32156606Imaging of intracellular calcium during desensitization of nicotinic acetylcholine receptors of rat chromaffin cells.
Q35119081Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors
Q71405653Inactivation (desensitization) of the acetylcholine receptor in Electrophorus electricus membrane vesicles by carbamylcholine: comparison between ion flux and alpha-bungarotoxin binding
Q40905705Inactivation of P2X2 purinoceptors by divalent cations
Q35951334Increased nicotinic receptor desensitization in hypoglossal motor neurons following chronic developmental nicotine exposure
Q42172647Indirect inhibitory effect of succinylcholine on acetylcholine‐activated channel activities and its modulation by external Ca2+ in mouse skeletal muscles
Q41848191Influence of SKF-525A congeners, strophanthidin and tissue-culture media on desensitization in frog skeletal muscle
Q52533010Influence of agonists on desensitization of glutamate receptors on locust muscle
Q41514076Influence of chloride ions on changes in membrane potential during prolonged application of carbachol to frog skeletal muscle
Q72931526Influence of presynaptic receptors on neuromuscular transmission in rat
Q48954592Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine.
Q68466414Influences of trypsin and collagenase on acetylcholine responses of physically isolated single neurons of Aplysia californica
Q36493659Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor
Q51238109Input organization of two symmetrical giant cells in the snail brain.
Q27010347Inside-out neuropharmacology of nicotinic drugs
Q72076140Interaction between nerve-related acetylcholine and bath applied agonists at the frog end-plate
Q42879293Interaction of di-iodinated 125I-labelled α-bungarotoxin and reversible cholinergic ligands with intact synaptic acetylcholine receptors on isolated skeletal-muscle fibres from the rat
Q66994157Interaction of permeant ions with channels activated by acetylcholine in Aplysia neurones
Q72936699Interactions between three slow potassium responses controlled by three distinct receptors in Aplysia neurones
Q28338845Interactions of piperidine derivatives with the nicotinic cholinergic receptor complex from Torpedo electric organ
Q44014619Interactions of suxamethonium and barbiturate drugs at the avian neuromuscular junction
Q41850989Interconversion between Different States of Affinity for Acetylcholine of the Cholinergic Receptor Protein from Torpedo marmorata
Q45287731Intrinsic fluorescence of the membrane-bound acetylcholine receptor: its quenching by suberyldicholine.
Q40147171Investigation of the alpha(1)-glycine receptor channel-opening kinetics in the submillisecond time domain
Q37613298Ion-dependent gating of kainate receptors
Q72220370Ionic Mechanism of Cholinergic inhibition in Molluscan Neurons
Q72220373Ionic Mechanisms of Cholinergic Excitation in Molluscan Neurons
Q40392683Ionic basis of GABAA receptor channel function in the nervous system
Q40841025Ionophore-mediated calcium influx effects on the post-synaptic muscle fibre membrane
Q39712662Isolation and Purification of the Nicotinic Acetylcholine Receptor and Its Functional Reconstitution into a Membrane Environment
Q48736468Kinetic analysis of interactions between kainate and AMPA: Evidence for activation of a single receptor in mouse hippocampal neurons
Q37592284Kinetic analysis of receptor-controlled tracer efflux from sealed membrane fragments
Q53880191Kinetic analysis of the agonistic and blocking properties of pentobarbital on recombinant rat alpha(1)beta(2)gamma(2S) GABA(A) receptor channels.
Q47844130Kinetic evidence that desensitized nAChR may promote transitions of active nAChR to desensitized states during sustained exposure to agonists in skeletal muscle
Q67342025Kinetic models of the drug-receptor interaction
Q52739091Kinetics of activation and desensitization in receptor proteins
Q34259046Kinetics of activation of acetylcholine receptors in a mouse muscle cell line under a range of acetylcholine concentrations
Q59071538Kinetics of agonist-induced intrinsic fluorescence changes in membrane-bound acetylcholine receptor
Q34028066Kinetics of agonist-induced intrinsic fluorescence changes in the Torpedo acetylcholine receptor
Q37728109Kinetics of desensitization and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells
Q41162483Kinetics of homomeric GluR6 glutamate receptor channels
Q45074590Kinetics of the membrane current mediated by serotonin 5-HT3 receptors in cultured mouse neuroblastoma cells
Q42129293Lack of run-down of smooth muscle P2X receptor currents recorded with the amphotericin permeabilized patch technique, physiological and pharmacological characterization of the properties of mesenteric artery P2X receptor ion channels
Q47782193Long-lasting inactivation of nicotinic receptor function in vitro by treatment with high concentrations of nicotine
Q48930266Long-term desensitization of nicotinic acetylcholine receptors is regulated via protein kinase A-mediated phosphorylation.
Q35753943Low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include α5 or α6 subunits and that mediate synaptosomal neurotransmitter release
Q24647069Mammalian nicotinic acetylcholine receptors: from structure to function
Q72414473Mechanical responses of the pigeon iris muscle fibres
Q27639007Mechanism of glutamate receptor desensitization
Q42018219Mechanism of staurosporine-induced decrease in acetylcholine receptor recovery from desensitization
Q40708436Mechanism of tacrine block at adult human muscle nicotinic acetylcholine receptors
Q51708624Mechanism of the blocking action of β-eudesmol on the nicotinic acetylcholine receptor channel in mouse skeletal muscles
Q30970994Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801.
Q40085079Mechanisms of Synaptic Modulation
Q37377637Mechanisms of activity-dependent plasticity in cellular nitric oxide-cGMP signaling
Q71071198Mechanisms of neuromuscular blockade
Q36598917Membrane interactions with general and local anaesthetics: A review of molecular hypotheses of anaesthesia
Q39109479Membrane permeability and receptor function
Q42635480Membrane potential responses to ionophoretically applied alpha-adrenoceptor agonists in the mouse anococcygeus muscle
Q86557487Membrane proteins: Through thick and thin
Q35897852Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors
Q42728501Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function
Q51905484Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.
Q37508580Modeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms
Q28323850Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle
Q44572986Modulation of GABA(A) receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process.
Q44297340Modulation of P2X3 receptors by Mg2+ on rat DRG neurons in culture
Q24672543Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells
Q46450796Molecular environment of the phencyclidine binding site in the nicotinic acetylcholine receptor membrane
Q72378901Molecular forces acting between ammonium ions and acetylcholine receptor
Q36355473Molecular mechanism of acetylcholine receptor-controlled ion translocation across cell membranes
Q33841981Momentary alteration of the postsynaptic membrane during transmission of a single nerve impulse
Q79287233Motor end-plate 'desensitization' by repetitive nerve stimuli
Q69010779Multiple actions of substance P that regulate the functional properties of acetylcholine receptors of clonal rat PC12 cells
Q69561676Multiple forms of acetylcholinesterase and their distribution in endplate and non-endplate regions of rat diaphragm muscle
Q70192738Multiple receptor sites for a molluscan peptide (FMRFamide) and related peptides of Helix
Q46866467Muscarinic agonists inactivate potassium conductance of guinea-pig myenteric neurones
Q46683522Muscarinic presynaptic inhibition of synaptic transmission in myenteric plexus of guinea-pig ileum
Q31870541Mutant mice as a model for cerebellar ataxia
Q34087945Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor
Q42617071Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
Q50789819Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic.
Q37361461N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes.
Q42020108Necessity of divalent cations for recovery from carbachol-induced nicotinic acetylcholine receptor inactivation at snake twitch fibre endplates
Q42103532Necessity of protein kinase C activity for maintenance of acetylcholine receptor function at snake twitch fibre endplates
Q36404659Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine
Q28141480Neuronal nicotinic receptors in the human brain
Q72722028Neuropeptides facilitate the desensitization of nicotinic acetylcholine-receptor in frog skeletal muscle endplate
Q39151674Neurophysiological mechanisms involved in photo-entrainment of the circadian rhythm from theAplysia eye
Q51841037Neurotensin receptors on the ileum of the guinea-pig: Evidence for the coexistence of inhibitory and excitatory receptors
Q67052941Neurotransmitter action on the membrane of Mytilus smooth muscle—I. Acetylcholine
Q34426718New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine
Q37756527Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
Q34552613Nicotine addiction: the possible role of functional upregulation
Q83473801Nicotine effects on human endothelial intercellular communication via α4β2 and α3β2 nicotinic acetylcholine receptor subtypes
Q40626831Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors.
Q37525085Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction
Q37398165Nicotinic acetylcholine receptor contains multiple binding sites: evidence from binding of alpha-dendrotoxin
Q60678643Nicotinic acetylcholine receptors in the nervous system
Q48510240Nicotinic acetylcholine receptors in the rat and primate nucleus tractus solitarius and on rat and human inferior vagal (nodose) ganglia: evidence from in vivo microdialysis and [125I]alpha-bungarotoxin autoradiography.
Q42004780Nicotinic and muscarinic modulation of 5-hydroxytryptamine (5-HT) release from porcine and canine small intestine
Q42009955Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording
Q48633564Nicotinic receptor-mediated responses in relay cells and interneurons in the rat lateral geniculate nucleus.
Q37590093Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Q40123161Noise analysis and channels at the postsynaptic membrane of skeletal muscle
Q40320195Non-linear dose-response relation at the frog neuromuscular junction
Q34190634Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
Q46843651Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.
Q40218679On the effect of ionophoretically applied dopamine on salivary gland cells of Nauphoeta cinerea
Q46778078On the mechanism of contraction and desensitization induced by substance P in the intestinal muscle of the guinea-pig
Q40269714Onset of neural function in the lateral line
Q72859974Open time of channels activated by binding of two distinct agonists
Q36869877Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor
Q91833966Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats
Q42688850PF4, a FMRFamide-related peptide, gates low-conductance Cl(-) channels in Ascaris suum
Q42014137Pentobarbital produces activation and block of {alpha}1{beta}2{gamma}2S GABAA receptors in rapidly perfused whole cells and membrane patches: divergent results can be explained by pharmacokinetics
Q46863226Pharmacological properties and H+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones
Q38016671Physiological cholinergic functions in the CNS.
Q39100677Polyfunctional role of glutamic acid in excitatory synaptic transmission
Q39957923Post-synaptic potentiation: interaction between quanta of acetylcholine at the skeletal neuromuscular synapse
Q43840022Postsynaptic mechanism of habituation of turtle cortical neurons to moving stimuli
Q52632080Potential errors in agonist dissociation constant estimation caused by desensitization.
Q36949979Potential therapeutic uses of mecamylamine and its stereoisomers
Q67297802Potentiation and desensitization after glutamate induced postsynaptic currents at the crayfish neuromuscular junction
Q69360086Potentiation and suppression by eserine of muscarinic synaptic transmission in the guinea-pig hippocampal slice
Q44075099Pre- and postsynaptic effects of the calcium channel blocker verapamil at neuromuscular junctions
Q34073244Presynaptic GABAB autoreceptor regulation of nicotinic acetylcholine receptor mediated [(3)H]-GABA release from mouse synaptosomes
Q47753738Presynaptic K(+) channels, vesicular Ca(2+)/H (+) antiport--synaptotagmin, and acetylcholinesterase, three mechanisms cutting short the cholinergic signal at neuromuscular and nerve-electroplaque junctions.
Q70886192Presynaptic mechanisms in myasthenia gravis
Q33267111Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel
Q64238658Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine
Q67792333Proceedings: Binding to nerve and muscle of saxitoxin labelled by a new method of tritium exchange
Q72891633Prolonged exposure to acetylcholine: noise analysis and channel inactivation in cat tenuissimus muscle
Q44100450Prolonged stimulation of presynaptic nicotinic acetylcholine receptors in the rat interpeduncular nucleus has differential effects on transmitter release
Q69389537Properties of putative nicotine receptors identified on cultured cortical neurons
Q61451953Prospective Hospital-Based Clinical and Electrophysiological Evaluation of Acute Organophosphate Poisoning
Q37616838Protease inhibitors implicate metalloendoprotease in synaptic transmission at the mammalian neuromuscular junction
Q41692617Protein dynamics and the allosteric transitions of pentameric receptor channels
Q44634107Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells
Q28142282Qualitative and quantitative assessment of relative agonist efficacy
Q66984662Quantification of synaptic vesicles in hippocampus of aging rats and initial studies of possible relations to neurophysiology
Q42665311Quinacrine (mepacrine) action at frog end-plate
Q37680957Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to kainate
Q39626423Rapid activation, desensitization, and resensitization of synaptic channels of crayfish muscle after glutamate pulses
Q36686211Rapid chemical kinetic techniques for investigations of neurotransmitter receptors expressed in Xenopus oocytes
Q35088740Rapid chemical reaction techniques developed for use in investigations of membrane-bound proteins (neurotransmitter receptors).
Q43625660Rapid desensitization of acetylcholine receptors of eel electroplaques following iontophoretic application of agonist compounds.
Q70561076Rapid recovery of nicotinic receptor-mediated sodium-22 influx following withdrawal from acute or chronic cholinergic stimulation
Q92491926Rapsyn facilitates recovery from desensitization in fetal and adult acetylcholine receptors expressed in a muscle cell line
Q79493570Rates of action of bath-applied drugs at the neuromuscular junction of the frog
Q52166046Rats exhibiting acute behavioural tolerance to nicotine have more [125I]alpha-bungarotoxin binding sites in brain than rats not exhibiting tolerance.
Q67295391Reaction of quinacrine mustard with the acetylcholine receptor from Torpedo californica
Q40139301Recent Developments in the Structure and Function of the Acetylcholine Receptor
Q53838294Receptor desensitization by lobeline and nicotine.
Q40077998Receptor sensitivity modification (RSM) — A new paradigm for the potential treatment of some hormonal and transmitter disturbances
Q68623498Receptor-mediated presynaptic facilitation of quantal release of acetylcholine induced by pralidoxime in Aplysia
Q39229302Receptors, Neurotransmitters and Drug Responses
Q36391228Reconstitution of purified acetylcholine receptors with functional ion channels in planar lipid bilayers
Q74315062Recovery from desensitization of neuronal nicotinic acetylcholine receptors of rat chromaffin cells is modulated by intracellular calcium through distinct second messengers
Q66881142Recovery of sensitivity to acetylcholine following desensitization in muscles of different vertebrate species
Q44093318Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion neurones
Q47864194Reduced behavioral effects of pilocarpine during chronic treatment with DFP.
Q48397732Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse.
Q93599489Regional differences in the electrical activity of the rabbit sinus node
Q35088265Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata
Q40084761Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythrocytes
Q49151499Regulation of the sensitivity of acetylcholine receptors to nicotine in rat habenula neurons.
Q72054359Relationship between frequency of stimulation and ganglionic blockade by drugs
Q34991997Relationship between the beta-adrenergic receptor and adenylate cyclase
Q40650023Relaxation experiments using bath-applied suberyldicholine
Q52520591Responses of flocculus and vestibular nuclei neurons in Weaver mutant mice (B6CBA wv/wv) to combined head and body rotation.
Q67657527Responses of identified spinal neurones to acetylcholine applied by micro-electrophoresis
Q54479243Responses of solitary retinal horizontal cells from Carassius auratus to L-glutamate and related amino acids
Q54477428Restoration of the nicotinic receptor-channel activity from the blockade by atropine in bullfrog sympathetic ganglia
Q40179405Role of calcium in the fade of the potassium release response in the rat parotid gland
Q36855415Role of intracellular calcium in fast and slow desensitization of P2-receptors in PC12 cells
Q41395664SOME EFFECTS OF LONG CHAIN POLYMETHYLENE BISONIUM SALTS ON JUNCTIONAL TRANSMISSION IN THE PERIPHERAL NERVOUS SYSTEM
Q46411420Selection of 2'-fluoro-modified RNA aptamers for alleviation of cocaine and MK-801 inhibition of the nicotinic acetylcholine receptor
Q52298021Selective depression of neuronal excitability during habituation
Q45125301Short-term desensitization of muscarinic K+ channel current in isolated atrial myocytes and possible role of GTP-binding proteins
Q40225675Signal transmission from red cones to horizontal cells in the turtle retina
Q54085329Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat.
Q42638285Single-channel current recordings of acetylcholine receptors in electroplax isolated from the Electrophorus electricus Main and Sachs' electric organs
Q35120131Sleuthing molecular targets for neurological diseases at the neuromuscular junction
Q48464836Sodium ions are necessary for cholinergic desensitization in molluscan neurons
Q36890441Solution binding of an antigenic peptide to a major histocompatibility complex class I molecule and the role of beta 2-microglobulin
Q48667179Somatic and dendritic actions of γ-aminobutyric acid agonists and uptake blockers in the hippocampusin vivo
Q68756928Some properties of the junctional and extrajunctional receptors in the vas deferens of the guinea-pig
Q46651187Specific desensitization to PGE1 and PGE2 in guinea-pig ileum; evidence for a common receptor síte
Q70914512Spontaneous recovery from depolarizing drugs in rat diaphragm
Q36412074State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit
Q41816586Staurosporine inhibits the extent of acetylcholine receptor recovery from carbachol-induced desensitization in snake twitch fibres
Q67685973Steep concentration dependence and fast desensitization of nicotinic channel currents elicited by acetylcholine pulses, studied in adult vertebrate muscle
Q24633112Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra)
Q40854845Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision
Q36531019Structural, Electrophysiological, Biochemical, and Pharmacological Properties of Neuroblastoma-Glioma Cell Hybrids in Cell Culture
Q26852212Structure and pharmacology of pentameric receptor channels: from bacteria to brain
Q52473633Structure and physiology of denervated and re-innervated cockroach muscle.
Q72536425Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the delta subunit within 0.9 nm of the 5 alpha subunit-binding
Q36260063Substance P modulation of acetylcholine-induced currents in embryonic chicken sympathetic and ciliary ganglion neurons
Q41484176Succinyl derivatives of N-tris (hydroxymethyl) methyl-2-aminoethane sulphonic acid: their effects on the frog neuromuscular junction
Q40036077Synaptic Transmission: Long-Lasting Potentiation by a Postsynaptic Mechanism
Q79203834Synaptic action during and after repetitive stimulation
Q47968740Synaptic connexions of two symmetrically placed giant serotonin-containing neurones
Q39235472Synaptic events in sympathetic ganglia
Q40025957Synaptic transmission between rat spinal cord explants and dissociated superior cervical ganglion neurons in tissue culture
Q70886222Syndromes simulating myasthenia gravis: asthenia with anticholinesterase tolerance
Q41026065Synthesis, photochemistry, and biological characterization of photolabile protecting groups for carboxylic acids and neurotransmitters
Q76679330THE BEHAVIOUR OF MAMMALIAN MOTONEURONES DURING LONG-LASTING ORTHODROMIC, ANTIDROMIC AND TRANS-MEMBRANE STIMULATION
Q76849785THE EFFECT ON CRAYFISH MUSCLE OF IONTOPHORETICALLY APPLIED GLUTAMATE
Q72850414Temperature Dependence of Muscarinic Acetylcholine Receptor Activation, Desensitization, and Resensitization
Q42035572Temperature effects in the stimulus-secretion process from isolated chromaffin cells
Q40036946The Comparative Physiology of Invertebrate Central Neurons
Q78995948The Effects in Rabbits of Thyroidectomy and Treatment with Triiodothyronine on the Sensitivity to Noradrenaline and the Content of Noradrenaline in Aorta and Spleen
Q36373910The Electrophysiology of Electric Organs of Marine Electric Fishes : I. Properties of electroplaques of Torpedo nobiliana
Q42946277The Electrophysiology of Electric Organs of Marine Electric Fishes : III. The electroplaques of the stargazer, Astroscopus y-graecum
Q39835300The Nicotinic Acetylcholine Receptor from Torpedo Electroplax
Q69135288The acetylcholine sensitivity in the vicinity of the neuromuscular junction of the frog
Q54452906The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture.
Q51791805The action of excitatory amino acids on chick spinal cord neurones in culture.
Q70886181The action of facilitatory drugs and acetylcholine on neuromuscular transmission
Q38007903The action of opioid drugs on human plasma cholinesterase
Q68396869The actions of suxamethonium (succinyldicholine) as an agonist and channel blocker at the nicotinic receptor of frog muscle
Q78785448The antagonism between tubocurarine and substances which depolarize the motor end‐plate
Q69102578The antagonistic effects of calcium and potassium on the time course of action of carbamylcholine at the neuromuscular junction
Q79203838The chemical excitation of spinal neurones by certain acidic amino acids
Q72082535The decay of end-plate currents in neostigmine-treated frog muscle blocked by acetylcholine or tubocurarine
Q39977073The desensitization gate of inhibitory Cys-loop receptors.
Q70563891The dissociation constant between curare and the acetylcholine receptor
Q39933324The distribution of acetylcholine sensitivity at the post-synaptic membrane of vertebrate skeletal twitch muscles: iontophoretic mapping in the micron range
Q87892073The dual-gate model for pentameric ligand-gated ion channels activation and desensitization
Q72697764The effect of acetylcholine upon mammalian motor nerve terminals
Q72398346The effect of calcium ions on the glutamate response and its desensitization in crayfish muscle fibres
Q78929719The effect of carbachol on the permeability of depolarized smooth muscle to inorganic ions
Q47967418The effect of iontophoretically applied acetylcholine upon the cat's retinal ganglion cells
Q79358232The effect of neuronal rest on the output of sympathetic transmitter from the spleen
Q41527416The effect of noradrenaline on the permeability of depolarized intestinal smooth muscle to inorganic ions
Q68795949The effect of repetitive neuromuscular activity on the sensitivity of acetylcholine receptors
Q45291835The effect of temperature on desensitization kinetics at the post-synaptic membrane of the frog muscle fibre
Q42447147The effect of the molecular mechanism of G protein-coupled receptor activation on the process of signal transduction
Q34745010The effective opening of nicotinic acetylcholine receptors with single agonist binding sites
Q51242131The excitation of Renshaw cells by cholinomimetics
Q77221440The excitation of Renshaw cells by pharmacological agents applied electrophoretically
Q44619441The fade of the response to acetylcholine at the rabbit isolated sino-atrial node
Q54675132The fall of pulmonary vascular resistance during severe asphyxia in foetal and new-born lambs
Q35205566The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis
Q39891601The functional organization within the ommatidium of the lateral eye of limulus
Q37637585The gating isomerization of neuromuscular acetylcholine receptors
Q41367149The impact of receptor desensitization on fast synaptic transmission
Q52518307The influence of concanavalin A on glutamate-induced current fluctuations in locust muscle fibres
Q44600733The influence of disulfide bond reduction and lanthanum on end-plate receptors
Q37352414The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization
Q40275484The kinetics of tubocurarine action and restricted diffusion within the synaptic cleft
Q47877077The location of the gate in the acetylcholine receptor channel
Q68569657The margin of safety of neuromuscular transmission
Q34128321The mechanism of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor desensitization after removal of glutamate
Q44915416The mechanisms underlying neuromuscular block following prolonged exposure to depolarizing agents
Q40092720The modulation of neurotransmitter release at synaptic junctions
Q28513760The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs
Q37703420The multiple phenotypes of allosteric receptor mutants
Q72811749The neuromuscular junction and mechanism of action of curariform drugs
Q88596100The nicotinic acetylcholine receptor: a typical 'allosteric machine'
Q40096542The pharmacology of molluscan neurons
Q54485622The pharmacology of the piperidine dicarboxylates on the crustacean neuromuscular junction
Q35327457The physiology of GABAA receptors in retinal neurons
Q70183674The piperidine analogues prevent desensitization of glutamate receptors on crustacean muscle
Q72497587The presynaptic effects of valproic acid in the isolated frog spinal cord
Q34174446The quality of maximum likelihood estimates of ion channel rate constants
Q24670242The receptor concept: pharmacology's big idea
Q72888488The recovery from desensitization of the glutamate receptor in the crayfish neuromuscular junction
Q78429225The relation between endplate depolarization and the repetitive response elicited in the isolated rat phrenic nervediaphragm preparation by DFP
Q42029490The responses to nerve stimulation of the salivary gland of Nauphoeta cinerea Olivier
Q46363702The role of acetylcholinesterase in denervation supersensitivity in the frog cardiac ganglion
Q73302761The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons
Q43542090The role of desensitisation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria
Q30461965The smoking cessation drug varenicline improves deficient P20-N40 inhibition in DBA/2 mice
Q70478626The statistical nature of the acetylcholine potential and its molecular components
Q38080450The structural mechanism of the Cys-loop receptor desensitization
Q41733241The subunit dominates the relaxation kinetics of heteromeric neuronal nicotinic receptors
Q40085407The termination of transmitter action at the crustacean excitatory neuromuscular junction
Q39145643The time course of cellular responses to iontophoretically applied drugs
Q41831321The time course of miniature endplate currents and its modification by receptor blockade and ethanol
Q46359892Tobacco nitrosamine N-nitrosonornicotine as inhibitor of neuronal nicotinic acetylcholine receptors
Q36374316Transient responses to sudden illumination in cells of the eye of Limulus
Q64786899Transitional states of central serotonin receptors in Parkinson's disease
Q41203200Tricks of perspective: insights and limitations to the study of macroscopic currents for the analysis of nAChR activation and desensitization
Q44610294Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells
Q67745864Two mechanisms for spontaneous recovery from depolarising drugs in rat muscle
Q46369907Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response
Q76455076Two new properties of foveal after-images and a photochemical hypothesis to explain them
Q52440540Two types of extrajunctional L‐glutamate receptors in locust muscle fibres
Q44868309Two types of nicotinic acetylcholine receptor channels at slow fibre end-plates of the garter snake
Q48521019Two types of steady-state desensitization of N-methyl-D-aspartate receptor in isolated hippocampal neurones of rat.
Q70990756Two-component desensitization at the neuromuscular junction of the frog
Q28366765Two-component desensitization of nicotinic receptors induced by acetylcholine agonists in Lymnaea stagnalis neurones
Q70171585Two-component desensitization of three types of responses to acetylcholine in Aplysia
Q50511086Ultrafast and Slow Cholinergic Transmission. Different Involvement of Acetylcholinesterase Molecular Forms.
Q36830063Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain
Q24634426Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors
Q48915839Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine.
Q43492644Use of the biological stimulus in determining parameters of drug action, and its relationship to the drug effect A contribution to the theory of drug action
Q42372959Use of the frog neuromuscular junction for assessing the action of drugs affecting synaptic transmission
Q40386589Use-dependent inhibition of P2X3 receptors by nanomolar agonist.
Q52546190Utilization of binding energy and coupling rules for active transport and other coupled vectorial processes.
Q35992141Volatile anesthetic facilitation of in vitro desensitization of membrane-bound acetylcholine receptor from Torpedo californica
Q24538986Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction
Q45051507Voltage clamp analysis of acetylcholine receptor desensitization in isolated mollusc neurones
Q42975074Voltage dependence of desensitization. Influence of calcium and activation kinetics
Q36432786Voltage- and time-dependent action of histrionicotoxin on the endplate current of the frog muscle
Q34183025Wavelet Analysis of Nonstationary Fluctuations of Monte Carlo-Simulated Excitatory Postsynaptic Currents
Q37601095What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor
Q52450808[Plasma and urine catecholamines in a 7-day survival of parathion poisoning].
Q40084797alpha-Adrenergic receptors in rat parotid cells. II. Desensitization of receptor binding sites and potassium release
Q52578301alpha7 receptor-selective agonists and modes of alpha7 receptor activation.
Q34998708beta-adrenergic receptors in rat liver: effects of adrenalectomy
Q90356662α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats
Q59009904‘Desensitization’ of Cholinergic Receptors by Acetylcholine in Molluscan Central Neurones

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