Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells

scientific journal article

Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M405100200
P698PubMed publication ID15272025

P2093author name stringKenji Sobue
Ken'ichiro Hayashi
Masahiro Watanabe
Tsuyoshi Morita
Kazuhiro Iwasaki
Katsushi Shibata
P2860cites workEpiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cellsQ24298549
Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling moleculesQ24313281
Phosphorylation and regulation of Raf by Akt (protein kinase B)Q28138863
The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signalingQ28284128
Molecular and cellular aspects of the insulin-like growth factor I receptorQ28288023
Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factorQ28615997
The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expressionQ28637904
Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptorQ28678384
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesQ29614338
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinasesQ29618331
Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1Q30176913
Positive and negative regulation of Src-family membrane kinases by CD45.Q33720532
Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell lineQ33775054
The insulin-like growth factor axis: A review of atherosclerosis and restenosisQ33832995
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatasesQ33947049
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferationQ34133504
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth controlQ35057313
The "Gab" in signal transduction.Q35082143
Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activationQ36667325
A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathwaysQ40021572
Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cellsQ40953884
Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferationQ41088100
The IRS-signalling system during insulin and cytokine actionQ41516480
The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cellsQ42971603
Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acidsQ43696097
Regulation of insulin-like growth factor I receptor dephosphorylation by SHPS-1 and the tyrosine phosphatase SHP-2.Q43847030
The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activationQ43993755
Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivoQ44592745
Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migrationQ47769116
Inhibition of vascular smooth muscle cell growth through antisense transcription of a rat insulin-like growth factor I receptor cDNA.Q48073155
The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.Q52195728
Integrin-Associated Protein Binding Domain of Thrombospondin-1 Enhances Insulin-Like Growth Factor-I Receptor Signaling in Vascular Smooth Muscle CellsQ57374813
P433issue39
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
preproinsulinQ7240673
P304page(s)40807–40818
P577publication date2004-09-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleInsulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells
P478volume279

Reverse relations

cites work (P2860)
Q35709811Cellular and Molecular Mechanisms of Phenotypic Switch in Gastrointestinal Smooth Muscle
Q35640301Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells
Q54466508Endothelial insulin-like growth factor-1 modulates proliferation and phenotype of smooth muscle cells induced by low shear stress.
Q51922958Expression profiles of nestin in vascular smooth muscle cells in vivo and in vitro.
Q90711245Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization
Q33855046Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells
Q26827352Involvement of protein tyrosine phosphatases in adipogenesis: new anti-obesity targets?
Q51158859Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors.
Q21131281Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
Q34146262Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering
Q36862768Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
Q41714511Nuclear Import Mechanism for Myocardin Family Members and Their Correlation with Vascular Smooth Muscle Cell Phenotype
Q35754163P-selectin activates integrin-mediated colon carcinoma cell adhesion to fibronectin
Q35055601PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates
Q91312846Prostaglandin D2 stimulates phenotypic changes in vascular smooth muscle cells
Q46972339Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
Q36870887Regulation and characteristics of vascular smooth muscle cell phenotypic diversity.
Q30354532Regulation of vascular smooth muscle phenotype by cross-regulation of krüppel-like factors
Q38165106Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance
Q37106652Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to fol
Q34966603Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
Q37865381Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Q35925223Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons.
Q36654406TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation
Q24563332The development and application of a quantitative peptide microarray based approach to protein interaction domain specificity space
Q36246905The early- and late stages in phenotypic modulation of vascular smooth muscle cells: differential roles for lysophosphatidic acid
Q37328039The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotype
Q33577586The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferation
Q37837732Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.
Q37551918β-Adrenergic Receptor and Insulin Resistance in the Heart

Search more.