Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways

scientific journal article

Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042312956
P356DOI10.1038/APS.2012.59
P3181OpenCitations bibliographic resource ID4115315
P932PMC publication ID4011150
P698PubMed publication ID22705730
P5875ResearchGate publication ID227171763

P2093author name stringYing Jin
Yan Dong
Qi Ding
Sheng-xue Yu
Hai-juan Sui
Wen-hui Qu
Ying-xin Jin
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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animalsQ33688733
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A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampusQ33898132
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The growing role of mTOR in neuronal development and plasticity.Q36739424
Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid raftsQ37254798
Long-term benefits after treatment of traumatic brain injury with simvastatin in ratsQ37341566
Involvement of Akt in neurite outgrowthQ37510693
Cholesterol and statins in Alzheimer's disease: current controversiesQ37603783
Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNFQ39654188
Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR.Q39882609
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathwayQ39946864
Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiationQ40192599
The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sitesQ40756366
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.Q41106936
Protective effects of statins involving both eNOS and tPA in focal cerebral ischemiaQ42552752
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytesQ42809294
Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons.Q43858169
HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cellsQ44264417
Statins induce angiogenesis, neurogenesis, and synaptogenesis after strokeQ44463534
Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injuryQ44534829
HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesisQ44804955
A positive role of the PI3-K/Akt signaling pathway in PC12 cell differentiation.Q45223846
Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neuronesQ45301947
Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatinQ46350606
Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivationQ46541840
Simvastatin promotes heat shock protein 27 expression and Akt activation in the rat retina and protects axotomized retinal ganglion cells in vivoQ46708089
Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.Q46843627
Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.Q46843629
Simvastatin promotes neurite outgrowth in the presence of inhibitory molecules found in central nervous system injuryQ48426747
The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons.Q48599703
Glycogen synthase kinase 3beta phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones.Q52174232
Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for met-triggered cortical neuron migrationQ81638656
P433issue7
P921main subjectneuriteQ1534415
P304page(s)861–872
P577publication date2012-07-01
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleAtorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways
P478volume33

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