| P50 | author | Yong-Chuan Zhu | Q91678326 |
| P2093 | author name string | Zhi-Qi Xiong | |
| P2860 | cites work | Recurrent mutations in the CDKL5 gene: genotype-phenotype relationships. | Q54505733 |
| | Developments in neuronal cell culture | Q59050425 |
| | An isoform of the severe encephalopathy-related CDKL5 gene, including a novel exon with extremely high sequence conservation, is specifically expressed in brain | Q60894792 |
| | Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 | Q22337290 |
| | CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome | Q24303656 |
| | Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region | Q24308698 |
| | The protein kinase complement of the human genome | Q24324497 |
| | Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation | Q24532056 |
| | CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail | Q24651382 |
| | Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines | Q24677936 |
| | Genome-wide atlas of gene expression in the adult mouse brain | Q26253934 |
| | Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions | Q28256167 |
| | CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery | Q28257945 |
| | Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder | Q28264533 |
| | Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1 | Q28268294 |
| | Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarization | Q28512224 |
| | CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling | Q28574630 |
| | Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways | Q28584332 |
| | NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation | Q28586738 |
| | Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2 | Q28941210 |
| | Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development | Q28975458 |
| | GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors | Q29547630 |
| | Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation | Q29616327 |
| | The DNA methyltransferases of mammals | Q29617317 |
| | The postsynaptic architecture of excitatory synapses: a more quantitative view | Q29617941 |
| | Rho GTPases in neuronal morphogenesis | Q29620432 |
| | Molecular mechanisms of dendritic spine morphogenesis | Q29903592 |
| | Amphiphysin I antisense oligonucleotides inhibit neurite outgrowth in cultured hippocampal neurons. | Q30176317 |
| | Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminals | Q30176331 |
| | Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. | Q30438464 |
| | Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. | Q30486698 |
| | Mapping pathological phenotypes in a mouse model of CDKL5 disorder | Q33623490 |
| | Recognition memory: what are the roles of the perirhinal cortex and hippocampus? | Q33938467 |
| | Development of long-term dendritic spine stability in diverse regions of cerebral cortex | Q33986592 |
| | Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling. | Q34097099 |
| | Diagnostic testing for Rett syndrome by DHPLC and direct sequencing analysis of the MECP2 gene: identification of several novel mutations and polymorphisms | Q34144292 |
| | Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity | Q34762533 |
| | The histone deacetylase HDAC4 regulates long-term memory in Drosophila | Q35071111 |
| | Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5 | Q35080413 |
| | The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development | Q35758529 |
| | CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization | Q35915948 |
| | Characterisation of CDKL5 Transcript Isoforms in Human and Mouse | Q36055559 |
| | Nucleokinesis in neuronal migration | Q36121319 |
| | An essential role for histone deacetylase 4 in synaptic plasticity and memory formation | Q36344938 |
| | Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. | Q36504423 |
| | The centrosome in neuronal development | Q36786169 |
| | Strategies for the identification of kinase substrates using analog-sensitive kinases | Q37671333 |
| | Early events in axon/dendrite polarization | Q38020191 |
| | CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility | Q38688252 |
| | Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). | Q38731458 |
| | CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells. | Q39291385 |
| | CDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice. | Q39827058 |
| | Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1. | Q39922592 |
| | CDKL5 localizes at the centrosome and midbody and is required for faithful cell division | Q41109322 |
| | HDAC4 governs a transcriptional program essential for synaptic plasticity and memory | Q41209497 |
| | Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons. | Q41745546 |
| | Synaptic strength regulated by palmitate cycling on PSD-95. | Q43960568 |
| | Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. | Q44365117 |
| | Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder. | Q46439424 |
| | Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways. | Q46843627 |
| | Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway. | Q46843629 |
| | Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors | Q47661198 |
| | Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice. | Q48183034 |
| | Characterisation of Cdkl5 transcript isoforms in rat. | Q48399614 |
| | Dendritic Spine "Dysgenesis" and Mental Retardation | Q48497882 |
| | The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex | Q48548114 |
| | HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder | Q48599692 |
| | Seizure variables and their relationship to genotype and functional abilities in the CDKL5 disorder | Q48766875 |
| | A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain. | Q49060228 |
| | CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons. | Q50305506 |
| | CDKL5 PROTEIN SUBSTITUTION THERAPY RESCUES NEUROLOGICAL PHENOTYPES OF A MOUSE MODEL OF CDKL5 DISORDER. | Q50535044 |
| | Identification of Direct Kinase Substrates via Kinase Assay-Linked Phosphoproteomics. | Q50910789 |
| | CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders. | Q51923623 |
| | The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5. | Q53075656 |
| | Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. | Q53828453 |
| P433 | issue | 1 | |
| P921 | main subject | CDKL5 deficiency disorder | Q40739448 |
| P1104 | number of pages | 12 | |
| P304 | page(s) | 8-19 | |
| P577 | publication date | 2018-10-19 | |
| P1433 | published in | Developmental Neurobiology | Q15716734 |
| P1476 | title | Molecular and Synaptic Bases of CDKL5 Disorder | |
| P478 | volume | 79 | |