| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2012PNAS..10921516W |
| P356 | DOI | 10.1073/PNAS.1216988110 |
| P932 | PMC publication ID | 3535652 |
| P698 | PubMed publication ID | 23236174 |
| P5875 | ResearchGate publication ID | 233909496 |
| P50 | author | Steven J. Siegel | Q38318779 |
| Edward S Brodkin | Q61108105 | ||
| Darren Goffin | Q64729401 | ||
| P2093 | author name string | Zhaolan Zhou | |
| Eric D Marsh | |||
| Julie A Blendy | |||
| Xinjian Zhu | |||
| Megan Allen | |||
| I-Ting Judy Wang | |||
| Andrew H Fairless | |||
| P2860 | cites work | Advances in autism | Q22241976 |
| Advances in autism genetics: on the threshold of a new neurobiology | Q22251023 | ||
| CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome | Q24303656 | ||
| Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function | Q24338263 | ||
| Rett syndrome: revised diagnostic criteria and nomenclature | Q24596295 | ||
| Shank3 mutant mice display autistic-like behaviours and striatal dysfunction | Q24597501 | ||
| mTOR: from growth signal integration to cancer, diabetes and ageing | Q24633662 | ||
| Synchronous neural oscillations and cognitive processes | Q28187856 | ||
| The story of Rett syndrome: from clinic to neurobiology | Q28256549 | ||
| Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2 | Q28268807 | ||
| What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy | Q28270699 | ||
| Theta rhythm of navigation: link between path integration and landmark navigation, episodic and semantic memory | Q28271256 | ||
| The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy | Q28272644 | ||
| Key clinical features to identify girls with CDKL5 mutations | Q28293847 | ||
| A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome | Q28504458 | ||
| CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling | Q28574630 | ||
| A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome | Q28586765 | ||
| Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes | Q29616326 | ||
| Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3 | Q29616516 | ||
| Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits | Q29618411 | ||
| Atm-deficient mice: a paradigm of ataxia telangiectasia | Q29619532 | ||
| New vistas for α-frequency band oscillations | Q30052035 | ||
| Validating γ oscillations and delayed auditory responses as translational biomarkers of autism | Q30372103 | ||
| Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses | Q30465294 | ||
| MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism | Q30475452 | ||
| Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs | Q31100056 | ||
| The two TORCs and Akt. | Q34617423 | ||
| Protein interactome reveals converging molecular pathways among autism disorders | Q35203610 | ||
| MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder | Q35823293 | ||
| Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. | Q35923213 | ||
| Adult Phenotypes in Angelman- and Rett-Like Syndromes | Q36006568 | ||
| CDKL5-Related Disorders: From Clinical Description to Molecular Genetics | Q36006599 | ||
| Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice | Q36737172 | ||
| CDKL5 mutations cause infantile spasms, early onset seizures, and severe mental retardation in female patients. | Q36930153 | ||
| A new look at gamma? High- (>60 Hz) γ-band activity in cortical networks: function, mechanisms and impairment | Q37804957 | ||
| The Role of Alpha-Band Brain Oscillations as a Sensory Suppression Mechanism during Selective Attention. | Q37903678 | ||
| PTEN signaling in autism spectrum disorders | Q38015944 | ||
| Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases | Q39663675 | ||
| mTOR phosphorylated at S2448 binds to raptor and rictor | Q39895095 | ||
| Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1. | Q39922592 | ||
| Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. | Q40491343 | ||
| Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations | Q42722242 | ||
| Physiological role for casein kinase 1 in glutamatergic synaptic transmission. | Q46598656 | ||
| Abnormal EEG lateralization in boys with autism | Q48130974 | ||
| Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains | Q48383242 | ||
| The development of visual- and auditory processing in Rett syndrome: an ERP study | Q48562255 | ||
| CDKL5 alterations lead to early epileptic encephalopathy in both genders | Q49032666 | ||
| Subgroups of autistic children based on social behavior display distinct patterns of brain activity | Q50303547 | ||
| CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons. | Q50305506 | ||
| Characterization of autism in young children with tuberous sclerosis complex | Q50311253 | ||
| Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model. | Q51820369 | ||
| CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders. | Q51923623 | ||
| Schizophrenia: reduced signal-to-noise ratio and impaired phase-locking during information processing | Q73765248 | ||
| Epilepsy. Genetics of early-onset epilepsy with encephalopathy | Q83364576 | ||
| P433 | issue | 52 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | autism | Q38404 |
| kinome | Q3197188 | ||
| P304 | page(s) | 21516-21521 | |
| P577 | publication date | 2012-12-10 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice | |
| P478 | volume | 109 |
| Q92130280 | A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| Q30607064 | AMPA receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures |
| Q64039595 | AMPA receptor dysregulation and therapeutic interventions in a mouse model of CDKL5 Deficiency Disorder |
| Q39183213 | APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures |
| Q92761256 | Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder |
| Q38981431 | Autism genetics - an overview |
| Q47698460 | Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation |
| Q35915948 | CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization |
| Q39827058 | CDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice. |
| Q41109322 | CDKL5 localizes at the centrosome and midbody and is required for faithful cell division |
| Q47134048 | CDKL5 variants: Improving our understanding of a rare neurologic disorder |
| Q30424295 | Cellular origins of auditory event-related potential deficits in Rett syndrome |
| Q36055559 | Characterisation of CDKL5 Transcript Isoforms in Human and Mouse |
| Q62084107 | Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics |
| Q53828453 | Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. |
| Q64939210 | Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Clinical Review. |
| Q92833487 | Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions |
| Q59303931 | Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome |
| Q55017288 | Functional abilities in children and adults with the CDKL5 disorder. |
| Q64078571 | Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist |
| Q55436457 | Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder. |
| Q89460115 | Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons |
| Q39103694 | Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex. |
| Q34097099 | Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling. |
| Q48183034 | Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice. |
| Q92565699 | Manipulating the Mouse Genome Using Recombineering |
| Q33623490 | Mapping pathological phenotypes in a mouse model of CDKL5 disorder |
| Q47661198 | Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors |
| Q92782695 | Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder? |
| Q91678331 | Molecular and Synaptic Bases of CDKL5 Disorder |
| Q33752190 | Molecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder |
| Q57029718 | Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers |
| Q28975458 | Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development |
| Q27308052 | Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies |
| Q36751552 | PreImplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling. |
| Q37352763 | Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1 |
| Q37639891 | Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder |
| Q88605499 | Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain |
| Q92919056 | Reigning in Excitatory Signaling in CDKL5 Deficiency |
| Q90748674 | Rett Syndrome and CDKL5 Deficiency Disorder: From Bench to Clinic |
| Q33762246 | Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice |
| Q36103911 | Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth |
| Q92160931 | Site-specific abnormalities in the visual system of a mouse model of CDKL5 deficiency disorder |
| Q38125969 | Synaptic plasticity and signaling in Rett syndrome. |
| Q35080413 | Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5 |
| Q33638849 | Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits |
| Q41412994 | The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse |
| Q89596064 | The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo |
| Q39140436 | Translational use of event-related potentials to assess circuit integrity in ASD. |
| Q55416149 | Utilizing Animal Models of Infantile Spasms. |
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