Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival

scientific journal article

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01026-13
P932PMC publication ID3838185
P698PubMed publication ID24043312

P50authorDavid JimenoQ40131447
David DíazQ56986922
Martin Perez-AndresQ61858055
Alberto OrfaoQ89543246
P2093author name stringRobert L Kortum
Eugenio Santos
Lawrence E Samelson
Fernando C Baltanás
Alicia Ginel-Picardo
Pilar Liceras-Boillos
P2860cites workA diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cellsQ24302377
The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling propertiesQ24601199
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesQ24683597
Regulation of small GTPases by GEFs, GAPs, and GDIsQ26825750
RasGRP is essential for mouse thymocyte differentiation and TCR signalingQ28589756
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.Q28595029
Ras oncogenes: split personalitiesQ29615405
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathwayQ30009940
The signal transduction through Grb2/Ash in hematopoietic cellsQ30176581
Control of B cell development by Ras-mediated activation of Raf.Q33887809
Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and developmentQ33965185
Inhibition of Grb2 expression demonstrates an important role in BCR–ABL-mediated MAPK activation and transformation of primary human hematopoietic cellsQ34565011
Regulation of B cell fates by BCR signaling componentsQ34612524
Malignant diseases in Noonan syndrome and related disordersQ34615128
Digital signaling and hysteresis characterize ras activation in lymphoid cellsQ34929087
Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycleQ34964571
Regulation of B-cell fate by antigen-receptor signalsQ35014068
Targeted Sos1 deletion reveals its critical role in early T-cell developmentQ35134263
Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cellsQ35666699
Deconstructing Ras signaling in the thymusQ36155051
Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stageQ36368736
Many faces of Ras activationQ37186900
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectivesQ37903698
Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesisQ39437389
M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2-Sos association and phosphatidylinositol 3-kinase activityQ40381107
A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsivenessQ41847723
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cellsQ41984660
Functional specificity of ras isoforms: so similar but so differentQ42784309
Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signalingQ42798741
Nucleolar disruption and cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in purkinje cellsQ43983188
K-Ras is essential for normal fetal liver erythropoiesisQ45219931
The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors.Q46704588
Bone marrow contributes simultaneously to different neural types in the central nervous system through different mechanisms of plasticity.Q50527344
Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemiaQ79811139
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectSOS Ras/Rac guanine nucleotide exchange factor 1Q14908125
SOS Ras/Rho guanine nucleotide exchange factor 2Q21498749
P304page(s)4562-4578
P577publication date2013-09-16
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleFunctional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival
P478volume33

Reverse relations

cites work (P2860)
Q88909501Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis
Q92839062Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma
Q36288646Mesenchymal stromal cells (MSCs) induce ex vivo proliferation and erythroid commitment of cord blood haematopoietic stem cells (CB-CD34+ cells).
Q30809654One-way membrane trafficking of SOS in receptor-triggered Ras activation
Q40089044Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
Q90629924RAS, wanted dead or alive: Advances in targeting RAS mutant cancers
Q38381506Ras activation revisited: role of GEF and GAP systems.
Q36356747Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells
Q39784785Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs.
Q60921003The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein
Q58093289Unique dependence on Sos1 in Kras-induced leukemogenesis

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