Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance

scientific journal article

Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.483198
P932PMC publication ID3843075
P698PubMed publication ID24142699

P50authorAdria GiaccaQ80162695
Paul W. FranklandQ88416174
P2093author name stringPeixiang Wang
Julie Turnbull
Xiaochu Zhao
Taline Naranian
Sandra Pereira
Anne L. Wheeler
Mark Piliguian
Arman Draginov
Nela Pencea
Nyrie Israelian
Erica Tiberia
Cameron A. Ackerley
Berge A. Minassian
Alexander Ivovic
Wen Qin Yu
P2860cites workAcute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.Q46359322
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Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy.Q46938722
Liver and peripheral tissue glycogen metabolism in obese mice: effect of a mixed meal.Q51598444
Deficiency of Sbds in the mouse pancreas leads to features of Shwachman-Diamond syndrome, with loss of zymogen granules.Q52624374
Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus.Q54299084
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.Q54332121
Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man.Q55060542
Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytesQ64376964
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Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunctionQ74191142
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose toleranceQ77652485
Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeedingQ77912057
A gel filtration assay to determine glycogen synthase activityQ81706753
Glycogen and its MetabolismQ22305786
Molecular physiology of mammalian glucokinaseQ24653018
Early-onset Lafora body diseaseQ28119103
Clinical and genetic heterogeneity of branching enzyme deficiency (glycogenosis type IV)Q28285077
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in miceQ28511659
PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolismQ28591679
Identification of a novel protein interacting with laforin, the EPM2a progressive myoclonus epilepsy gene productQ30940680
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transductionQ33599031
Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out miceQ33800037
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolismQ33830715
Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism.Q33913304
Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforinQ34055790
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulationQ34089899
Mutations in NHLRC1 cause progressive myoclonus epilepsyQ34228381
Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitusQ34236518
Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptakeQ34243161
Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsyQ34754070
Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora diseaseQ36038840
Link between obesity and type 2 diabetesQ36324084
Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanismsQ37359438
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humansQ37379144
Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance.Q37408157
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscleQ39638100
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscleQ40721809
Zonation of parenchymal and nonparenchymal metabolism in liverQ41138372
Role of glucose effectiveness in the determination of glucose toleranceQ41170043
Abnormal metabolism of glycogen phosphate as a cause for Lafora diseaseQ41502630
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetesQ41743578
Glycogen hyperphosphorylation underlies lafora body formationQ42815700
Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitusQ43259516
Progressive defect of insulin action on glycogen synthase in obesity and diabetesQ43973161
Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the diseaseQ44055638
Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exerciseQ45265130
Hyperinsulinemic-euglycemic clamp to assess insulin sensitivity in vivo.Q45979025
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
preproinsulinQ7240673
Glycogen synthase 1, muscleQ21496445
EPM2A (laforin) interacting protein 1Q21981084
P304page(s)34627–34637
P577publication date2013-11-29
P1433published inJournal of Biological ChemistryQ867727
P1476titleDeficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance
P478volume288

Reverse relations

cites work (P2860)
Q90359204Lafora disease: from genotype to phenotype
Q47596109Microcystin-LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase
Q52372559The dynamic life of the glycogen granule.

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