| scholarly article | Q13442814 |
| P2093 | author name string | D L Price | |
| G Thinakaran | |||
| H H Slunt | |||
| S S Sisodia | |||
| S E Gandy | |||
| M K Lee | |||
| L J Martin | |||
| E Koo | |||
| G Kim | |||
| M Seeger | |||
| P2860 | cites work | Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 |
| Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
| Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications | Q24561689 | ||
| Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 | Q25938983 | ||
| Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease | Q26778460 | ||
| Localization of neuronal and glial glutamate transporters | Q28238076 | ||
| Transcription of the dystrophin gene in human muscle and non-muscle tissue | Q28295008 | ||
| Candidate gene for the chromosome 1 familial Alzheimer's disease locus | Q28295424 | ||
| Jagged: a mammalian ligand that activates Notch1 | Q28298760 | ||
| Notch2: a second mammalian Notch gene | Q28568315 | ||
| The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium | Q28623130 | ||
| Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Q29614374 | ||
| The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis | Q30455473 | ||
| Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice | Q33575703 | ||
| Genetic dissection of Alzheimer disease, a heterogeneous disorder | Q33909158 | ||
| Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene | Q34296093 | ||
| Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene | Q34303468 | ||
| Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. | Q34351242 | ||
| Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. | Q34372665 | ||
| A familial Alzheimer's disease locus on chromosome 1. | Q34720942 | ||
| Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions | Q36531974 | ||
| The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families | Q36680315 | ||
| Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). | Q36761978 | ||
| Amyloid precursor protein in aged nonhuman primates | Q37406618 | ||
| Identification and characterization of presenilin I-467, I-463 and I-374. | Q39420719 | ||
| Regional and cellular presenilin 1 gene expression in human and rat tissues | Q41226398 | ||
| Mutations of the presenilin I gene in families with early-onset Alzheimer's disease | Q41263613 | ||
| Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. | Q41746563 | ||
| A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. | Q42635612 | ||
| Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. | Q43597292 | ||
| Expression analysis of a Notch homologue in the mouse embryo | Q48146069 | ||
| Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation | Q48289360 | ||
| Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques | Q48299902 | ||
| Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry | Q48321891 | ||
| Immunohistochemical analysis of presenilin-1 expression in the mouse brain. | Q49017630 | ||
| Complementary and combinatorial patterns of Notch gene family expression during early mouse development. | Q52204884 | ||
| Expression and cellular localization of amyloid beta-protein precursor transcripts in normal human brain and in Alzheimer's disease. | Q53187075 | ||
| Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. | Q53190283 | ||
| Familial Alzheimer's chromosome 14 mutations | Q53200554 | ||
| Mutation analysis of presenillin 1 gene in Alzheimer's disease. | Q53210319 | ||
| Familial Alzheimer's disease associated with S182 codon 286 mutation | Q56766046 | ||
| Missense on the membrane | Q60075531 | ||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Presenilin 1 | Q21496912 |
| P1104 | number of pages | 13 | |
| P304 | page(s) | 7513-7525 | |
| P577 | publication date | 1996-12-01 | |
| P1433 | published in | Journal of Neuroscience | Q1709864 |
| P1476 | title | Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues | |
| P478 | volume | 16 |
| Q39326849 | A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. |
| Q33985318 | AL1-dependent repression of transcription enhances expression of Tomato golden mosaic virus AL2 and AL3. |
| Q34135702 | Aberrant regulation of alternative pre-mRNA splicing in schizophrenia |
| Q48266279 | Abnormal blood vessel development in mice lacking presenilin-1. |
| Q85209758 | Abnormalities in periodontal and salivary tissues in conditional presenilin 1 and presenilin 2 double knockout mice |
| Q48487111 | Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. |
| Q51737243 | Age and sex dependent alteration in presenilin expression in mouse cerebral cortex. |
| Q33556372 | Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations |
| Q48255634 | Alterations in presenilin 1 processing by amyloid-beta peptide in the rat retina |
| Q28512843 | Altered Abeta formation and long-term potentiation in a calsenilin knock-out |
| Q30493972 | Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2. |
| Q40811657 | Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments |
| Q35583236 | BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology |
| Q44814697 | Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. |
| Q28220167 | Biochemical and immunocytochemical characterization of calsenilin in mouse brain |
| Q38122497 | Biological function of Presenilin and its role in AD pathogenesis |
| Q37485864 | CSF Presenilin-1 complexes are increased in Alzheimer's disease |
| Q33854277 | Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains |
| Q33564277 | Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. |
| Q42455675 | Cloning and characterization of the presenilin-2 gene promoter |
| Q40040982 | Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system |
| Q40982564 | Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. |
| Q37718540 | Control of intracellular calcium signaling as a neuroprotective strategy |
| Q28209723 | Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces |
| Q36438492 | Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. |
| Q34104238 | Developmental mechanisms in the pathogenesis of neurodegenerative diseases |
| Q39398322 | Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice |
| Q40931378 | Differential effects of transforming growth factor-beta(s) and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes |
| Q44607474 | Differential expression of presenilin-alpha and -beta (PSalpha and PSbeta) in Xenopus laevis: embryonic phosphorylation of PSalpha |
| Q28139646 | Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071 |
| Q48327056 | Effects of PS1 deficiency on membrane protein trafficking in neurons |
| Q30727892 | Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix |
| Q35312062 | Epithelial cell adhesion molecule (EpCAM) complex proteins promote transcription factor-mediated pluripotency reprogramming |
| Q48460568 | Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain. |
| Q39623334 | Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2 |
| Q48321760 | Expression of presenilin 1 and synapse‐related proteins during postnatal development is not different between accelerated senescence‐prone and ‐resistant mice |
| Q48100422 | Expression of presenilin 1 mRNA in rat peripheral organs and brain |
| Q48919818 | Expression of presenilin-1 and Notch-1 receptor in human embryonic CNS. |
| Q35924427 | Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice |
| Q33655110 | Function and dysfunction of the presenilins |
| Q34240266 | Genes, models and Alzheimer's disease |
| Q38579624 | Genetic studies in Alzheimer's disease. |
| Q34509807 | Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics |
| Q48115090 | HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans |
| Q30476254 | Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice |
| Q24617724 | Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages |
| Q48675035 | Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. |
| Q34104501 | Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins |
| Q36273909 | Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). |
| Q46778664 | Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury |
| Q48184379 | Induction of presenilins in the rat brain after middle cerebral arterial occlusion |
| Q24674595 | Interaction of presenilins with the filamin family of actin-binding proteins |
| Q38298645 | Interactions between fibroblast growth factors and Notch regulate neuronal differentiation. |
| Q36873732 | Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. |
| Q93000628 | Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2 |
| Q47830593 | Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. |
| Q35764570 | Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy |
| Q53466041 | Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness. |
| Q35185679 | Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels. |
| Q41751563 | Metabolism of presenilin 1: influence of presenilin 1 on amyloid precursor protein processing |
| Q35107227 | Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects |
| Q28508946 | Mice lacking both presenilin genes exhibit early embryonic patterning defects |
| Q41673213 | Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation. |
| Q38082670 | Molecular basis of etiological implications in Alzheimer's disease: focus on neuroinflammation |
| Q41951653 | Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain |
| Q33842568 | Molecular genetics of Alzheimer's disease. |
| Q32052477 | Molecular mechanisms that underlie structural and functional changes at the postsynaptic membrane during synaptic plasticity |
| Q43234982 | Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice. |
| Q48491870 | Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. |
| Q41612519 | Neural recognition molecules and synaptic plasticity |
| Q28513269 | Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene |
| Q48679471 | Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. |
| Q34687686 | Neurons bearing presenilins: weapons for defense or suicide? |
| Q73222823 | No association between an intronic presenilin-1 gene polymorphism and schizophrenia in a Chinese population |
| Q53534066 | PS1 expression is downregulated by gonadal steroids in adult mouse brain. |
| Q34803524 | Pathological and physiological functions of presenilins |
| Q39320295 | Presenilin 1 cleavage is a universal event in human organs |
| Q58695656 | Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling |
| Q36540223 | Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation. |
| Q28592290 | Presenilin 1 is essential for cardiac morphogenesis |
| Q28585594 | Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm |
| Q28505078 | Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency |
| Q33785755 | Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release |
| Q47068897 | Presenilin is required for proper morphology and function of neurons in C. elegans |
| Q33971264 | Presenilin structure, function and role in Alzheimer disease. |
| Q36481687 | Presenilin transgenic mice as models of Alzheimer's disease |
| Q28587858 | Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly |
| Q52171182 | Presenilin-1 protein specifically expressed in Leydig cells with its expression level increased during rat testis development. |
| Q33918695 | Presenilin/gamma-Secretase and Inflammation |
| Q28817811 | Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection |
| Q41652301 | Presenilins and Alzheimer's disease |
| Q33835683 | Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms |
| Q71952844 | Presenilins, amyloid-beta and Alzheimer's disease |
| Q71821474 | Protein topology of presenilin 1 |
| Q48247590 | Regional distribution of presenilin-1 messenger RNA in the embryonic rat brain: comparison with beta-amyloid precursor protein messenger RNA localization |
| Q46755710 | Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin |
| Q44070760 | Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease |
| Q28238795 | Skeletal and CNS defects in Presenilin-1-deficient mice |
| Q24657353 | Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells |
| Q47673255 | Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing. |
| Q40524258 | Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. |
| Q37370537 | Transcriptional regulation and its misregulation in Alzheimer's disease |
| Q37979824 | Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions |
| Q38938820 | Twenty Years of Presenilins--Important Proteins in Health and Disease |
| Q74248964 | Wnt signaling function in Alzheimer's disease |
| Q28534781 | Γ-secretase components as predictors of breast cancer outcome |
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