HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans (scientific article)

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Q28505078

Mice lacking both presenilin genes exhibit early embryonic patterning defects

Q28508946

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

Q28593166

Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss

Q28775792

The canonical Notch signaling pathway: unfolding the activation mechanism

Q29547725

Identification of genes expressed in the hermaphrodite germ line of C. elegans using SAGE.

Q33441953

Insulin signaling promotes germline proliferation in C. elegans

Q33684279

Progression from a stem cell-like state to early differentiation in the C. elegans germ line

Q33719898

gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans

Q33964440

Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development

Q33965838

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

Q34137893

glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans

Q34187240

On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans

Q34486706

Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans.

Q34572568

Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.

Q34616853

The γ-secretase complex: from structure to function

Q34677532

The million mutation project: a new approach to genetics in Caenorhabditis elegans

Q34783904

Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline

Q34966414

Cellular analyses of the mitotic region in the Caenorhabditis elegans adult germ line

Q35001866

The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

Q35683768

spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily

Q35848041

Analysis of Germline Stem Cell Differentiation Following Loss of GLP-1 Notch Activity in Caenorhabditis elegans

Q36050084

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

Q36643459

A condensin-like dosage compensation complex acts at a distance to control expression throughout the genome

Q37135166

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

Q37190073

Stem cell proliferation versus meiotic fate decision in Caenorhabditis elegans

Q37207233

MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans

Q37311671

Mated progeny production is a biomarker of aging in Caenorhabditis elegans

Q37366544

Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms

Q37812057

Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans

Q39750956

lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans

Q39757556

Thinking about genetic redundancy

Q40815570

A global profile of germline gene expression in C. elegans

Q43535217

Differential timing of S phases, X chromosome replication, and meiotic prophase in the C. elegans germ line.

Q46183863

Presenilin is required for proper morphology and function of neurons in C. elegans

Q47068897

The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate

Q47068925

Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline

Q47069123

Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.

Q47069195

Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans

Q47327774

Actin-dependent cytoplasmic streaming in C. elegans oogenesis.

Q48793073

Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors.

Q50972299

The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function.

Q52112876

Evolution of genetic redundancy.

Q52193461

Caenorhabditis elegans germline patterning requires coordinated development of the somatic gonadal sheath and the germ line

Q81446252

Quantitative analysis of germline mitosis in adult C. elegans

Q82562472

P4510

describes a project that uses

ImageJ

Q1659584

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

Caenorhabditis elegans

Q91703

P304

page(s)

745-762

P577

publication date

2017-12-14

P1433

published in

Genetics

Q3100575

P1476

title

HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans

P478

volume

208

Reverse relations

cites work (P2860)

Q90341020	Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis
Q58582163	Cell Cycle Analysis in the C. elegans Germline with the Thymidine Analog EdU
Q90251987	PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
Q92765412	Rapid population-wide declines in stem cell number and activity during reproductive aging in C. elegans